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• W2059365533 abstract "You have accessJournal of UrologyBladder Cancer: Superficial II1 Apr 20121782 THE ROLE OF IMMEDIATE RADICAL CYSTECTOMY IN THE TREATMENT OF PATIENTS WITH RESIDUAL T1 ON RESTAGING TRANSURETHRAL RESECTION Itay A. Sternberg, Gal E. Keren Paz, Ling Y. Chen, Andrew J. Vickers, Harry W. Herr, and Guido Dalbagni Itay A. SternbergItay A. Sternberg New York, NY More articles by this author , Gal E. Keren PazGal E. Keren Paz New York, NY More articles by this author , Ling Y. ChenLing Y. Chen New York, NY More articles by this author , Andrew J. VickersAndrew J. Vickers New York, NY More articles by this author , Harry W. HerrHarry W. Herr New York, NY More articles by this author , and Guido DalbagniGuido Dalbagni New York, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1799AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Residual T1 bladder cancer on restaging transurethral resection (re-TURBT) may be treated either aggressively with immediate radical cystectomy (IRC) or conservatively with deferred or no RC. We hypothesized that patients treated aggressively would have a survival advantage over those managed conservatively. METHODS Review of our database identified 157 patients diagnosed with T1 between 1990 and 2007 who had residual T1 on re-TURBT, defined as a repeat TUR within 3 months of initial T1 diagnosis. IRC was defined as RC performed within 3 months of re-TURBT. Patients not treated with RC within 3 months were regarded as treated conservatively. Patients were followed every 3-6 months. Seven patients died within 3 months of re-TURBT, thus landmark survival analysis was used. Kaplan-Meier curves were drawn to determine the difference in cancer specific survival (CSS) between the two groups. Univariate Cox proportional hazards regression model was used to test the association between treatment approach and CSS. RESULTS No differences in baseline clinical characteristics were observed between the two groups other than BCG treatment. This was an expected difference as patients treated conservatively were likely treated with BCG. The median follow up in event free patients was 2.8 years. Cancer specific mortality occurred in 16 patients during the follow up. There was no statistically significant association between immediate cystectomy and CSS (figure; hazard ratio: 1.15, 95%CI: 0.43, 3.09, p=0.8). CONCLUSIONS The non-significant result is not surprising given the low event rate and small sample. The results are compatible with IRC reducing cancer-specific mortality by a little more than half. A larger study with longer follow up is needed to obtain more precise estimates for the effect of IRC. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e719 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Itay A. Sternberg New York, NY More articles by this author Gal E. Keren Paz New York, NY More articles by this author Ling Y. Chen New York, NY More articles by this author Andrew J. Vickers New York, NY More articles by this author Harry W. Herr New York, NY More articles by this author Guido Dalbagni New York, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2059365533 title "1782 THE ROLE OF IMMEDIATE RADICAL CYSTECTOMY IN THE TREATMENT OF PATIENTS WITH RESIDUAL T1 ON RESTAGING TRANSURETHRAL RESECTION" @default.
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