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- W2059370800 abstract "<h3>To the Editor.—</h3> Retinoids (13-<i>cis</i>-retinoic acid or isotretinoin, and<i>trans</i>-retinoic acid or tretinoin) are therapeutic antiacne agents that affect sebaceous gland function and keratinization. Recently, it has been determined that both<i>trans</i>-retinoic acid and 13-<i>cis</i>-retinoic acid are normal constituents of human serum.<sup>1</sup>Circulating 13-<i>cis</i>-retinoic acid is derived from endogenous isomerization of<i>trans</i>-retinoic acid, while<i>trans</i>-retinoic acid is related to dietary intake and originates as a by-product of retinol metabolism.<sup>1</sup>We evaluated whether endogenous plasma retinoids protect against acne determining if lower values are present in affected patients. Simultaneously, we measured other factors that might be involved in the pathogenesis of acne. <h3>Materials and Methods.—</h3> The study population comprised 19 individuals with acne (ages, 21 to 43 years; median age, 25 years) and 19 non-acne control subjects matched by age (27 to 42 years; median age, 26), sex, and" @default.
- W2059370800 created "2016-06-24" @default.
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- W2059370800 date "1991-07-01" @default.
- W2059370800 modified "2023-09-26" @default.
- W2059370800 title "Are Endogenous Retinoids Involved in the Pathogenesis of Acne?" @default.
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- W2059370800 doi "https://doi.org/10.1001/archderm.1991.01680060148034" @default.
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