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- W2059371570 abstract "In order to accelerate the elimination of internally deposited 137Cs from the human body, we noticed the effectiveness of ferrocyanides of transition metals used for concentrating radiocesium from fission product mixtures. Prussian blue which is an iron ferrocyanide powder, has been employed in eliminating 137Cs from rat and man. Our chemistry group developed various ferrocyanide metals firmly bound in an anion exchange resin, and found that “nickel ferrocyanide-anion exchange resin” (NiFC)R was most stable in a wide range of hydrogen ion concentration and had a larger adsorbability for cesium than ferrocyanide salt. Several experiments were carried out on the effect of (NiFC)R and (FeFC)R (iron ferrocyanide-anion exchange resin) upon acute and chronic intake of 137Cs by rats and mice. Both “ferrocyanide-resins” were very effective in eliminating 137Cs, but (NiFC)R showed a slightly better efficiency. Long term toxicity studies were made using rats as a preliminary step to human application of (NiFC)R. The (NiFC)R mixed with foods was given to the rats for about 150 days, and then the rats were sacrificed for histo-pathological examination. No change was observed between the control group and those fed with (NiFC)R. From the result of these experiments, we decided to use (NiFC)R for two adult human males. The first experiment was performed as follows: 50 nCi of carrier-free 137Cs was ingested and 1 g, 0.5 g and 0.5 g of (NiFC)R was given at 10 min, 4 hr and 8 hr respectively after 137Cs ingestion. Excretion of 137Cs after 24 hr was about 40% of the ingested dose in comparison with about 5% without (NiFC)R dosing. The second experiment was as follows: 200 nCi of carrierfree 137Cs was ingested and then 0.5 g of (NiFC)R was given four times per day from the 21st to the 29th day following 137Cs ingestion. Excretion rates, as measured from the whole body retention curves, were about twice that during the period in which no (NiFC)R was given. Moreover, no side effects were observed for the two subjects. Thus, we may conclude that (NiFC)R can be successfully used to enhance the elimination of 137Cs from the body." @default.
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- W2059371570 date "1971-01-01" @default.
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- W2059371570 title "Application of Metal Ferrocyanide-anion Exchange Resin to the Enhancement of Elimination of 137Cs from Human Body" @default.
- W2059371570 doi "https://doi.org/10.1097/00004032-197101000-00002" @default.
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