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• W2059374950 startingPage "83" @default.
• W2059374950 abstract "Investigations on carrier-based drug delivery systems for higher selectivity in hair therapy have clearly evolved from dye release and model studies to highly sophisticated approaches, many of which specifically tackle hair indications and the delivery of hair-relevant molecules. Here, we group recent hair disease-oriented work into efforts towards (i) improved delivery of conventional drugs, (ii) delivery of novel drug classes, for example biomolecules and (iii) targeted delivery on the cellular/molecular level. Considering the solid foundation of experimental work, it does not take a large step outside the current box of thinking to follow the idea of using large carriers (>500 nm, unlikely to penetrate as a whole) for follicular penetration, retention and protection of sensitive compounds. Yet, reports on particles <200 nm being internalized by keratinocytes and dendritic cells at sites of barrier disruption (e.g., hair follicles) combined with recent advances in nanodermatology add interesting new facets to the possibilities carrier technologies could offer, for example, unprecedented levels of selectivity. The authors provide thought-provoking ideas on how smart delivery technologies and advances in our molecular understanding of hair pathophysiology could result in a whole new era of hair therapeutics. As the field still largely remains in preclinical investigation, determined efforts towards production of medical grade material and truly translational work are needed to demonstrate surplus value of carrier systems for clinical applications." @default.
• W2059374950 created "2016-06-24" @default.
• W2059374950 creator A5015290431 @default.
• W2059374950 creator A5037986822 @default.
• W2059374950 date "2014-01-29" @default.
• W2059374950 modified "2023-10-03" @default.
• W2059374950 title "Selective hair therapy: bringing science to the fiction" @default.
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• W2059374950 doi "https://doi.org/10.1111/exd.12318" @default.
• W2059374950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24387677" @default.
• W2059374950 hasPublicationYear "2014" @default.
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