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- W2059381197 abstract "A novel phosphodiester receptor 1-(2-guanidinoethyl)-4-(2-hydroxyethyl)-1,4,7-triazacyclononane hydrochloride 1 was synthesized. DNA cleavage efficiency of 1 exhibits remarkable increases compared with its ZnII complex and corresponding nonguanidinium compound N-(2-hydroxyethyl)-1,4,7-triazacyclononane and parent 1,4,7-triazacyclononane. Kinetic data of DNA cleavage promoted by 1 fit to a Michaelis−Menten-type equation with kmax of 0.160 h-1 giving 107-fold rate acceleration over uncatalyzed DNA. The acceleration is driven by the spatial proximity of the nucleophilic hydroxyl group and the electrophilic activation for the phosphodiester by the guanidinium group." @default.
- W2059381197 created "2016-06-24" @default.
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- W2059381197 date "2007-02-02" @default.
- W2059381197 modified "2023-10-16" @default.
- W2059381197 title "Synthesis and DNA Cleavage Activity of Artificial Receptor 1,4,7-Triazacyclononane Containing Guanidinoethyl and Hydroxyethyl Side Arms" @default.
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- W2059381197 doi "https://doi.org/10.1021/jo0624041" @default.
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