FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059383510> ?p ?o ?g. }

• W2059383510 endingPage "936" @default.
• W2059383510 startingPage "931" @default.
• W2059383510 abstract "Genetic or nutritional disorders in homocysteine (Hcy) or folate metabolism elevate plasma Hcy-thiolactone and lead to vascular and/or brain pathologies. Hcy-thiolactone has the ability to form isopeptide bonds with protein lysine residues, which generates N-Hcy-protein with autoimmunogenic and prothrombotic properties. Paraoxonase (PON1), carried on high-density lipoproteins (HDLs) in the blood, hydrolyzes Hcy-thiolactone and protects against the accumulation of N-Hcy-protein in vitro. To determine its role in vivo, we studied how natural variation in Hcy-thiolactonase activity of PON1 affects plasma N-Hcy-protein levels in cystathionine ß-synthase-deficient patients (n=28). We found that plasma N-Hcy-protein was negatively correlated with serum Hcy-thiolactonase activity (r=-0.43, P=0.01), i.e., the higher the Hcythiolactonase activity, the lower N-Hcy protein levels. This relation was faithfully replicated in vitro in experiments with radiolabeled Hcy-thiolactone. We also found that enzymatic activities of the PON1 protein measured with artificial substrates correlated less strongly (r=-0.36, P=0.025 for paraoxonase activity) or did not correlate at all (phenylacetate hydrolase and TBLase activities) with plasma N-Hcy protein. These findings provide evidence that the Hcy-thiolactonase activity of PON1 is a determinant of plasma N-Hcy-protein levels and that Hcy-thiolactonase/PON1 protects proteins against N-homocysteinylation in vivo, a novel mechanism likely to contribute to atheroprotective roles of HDL in humans.—Perla-Kaján, J., Jakubowski, H. Paraoxonase 1 protects against protein N-homocysteinylation in humans. FASEB J. 24, 931–936 (2010). www.fasebj.org" @default.
• W2059383510 created "2016-06-24" @default.
• W2059383510 creator A5039398608 @default.
• W2059383510 creator A5062502288 @default.
• W2059383510 date "2009-10-30" @default.
• W2059383510 modified "2023-10-17" @default.
• W2059383510 title "Paraoxonase 1 protects against protein<i>N</i>‐homocysteinylation in humans" @default.
• W2059383510 cites W1486644147 @default.
• W2059383510 cites W1664335312 @default.
• W2059383510 cites W1671050155 @default.
• W2059383510 cites W1940298872 @default.
• W2059383510 cites W1948500600 @default.
• W2059383510 cites W1967780117 @default.
• W2059383510 cites W1968382122 @default.
• W2059383510 cites W1972212924 @default.
• W2059383510 cites W1978117628 @default.
• W2059383510 cites W1998952324 @default.
• W2059383510 cites W2001673678 @default.
• W2059383510 cites W2008378566 @default.
• W2059383510 cites W2012489381 @default.
• W2059383510 cites W2015904681 @default.
• W2059383510 cites W2017564694 @default.
• W2059383510 cites W2019767870 @default.
• W2059383510 cites W2021395497 @default.
• W2059383510 cites W2023784332 @default.
• W2059383510 cites W2028237439 @default.
• W2059383510 cites W2036369851 @default.
• W2059383510 cites W2052869577 @default.
• W2059383510 cites W2061663562 @default.
• W2059383510 cites W2069097757 @default.
• W2059383510 cites W2072402720 @default.
• W2059383510 cites W2078369761 @default.
• W2059383510 cites W2078951566 @default.
• W2059383510 cites W2086911626 @default.
• W2059383510 cites W2092199973 @default.
• W2059383510 cites W2101135741 @default.
• W2059383510 cites W2112974685 @default.
• W2059383510 cites W2116163597 @default.
• W2059383510 cites W2119674873 @default.
• W2059383510 cites W2137387976 @default.
• W2059383510 cites W2149135423 @default.
• W2059383510 cites W2153856509 @default.
• W2059383510 cites W2166691340 @default.
• W2059383510 cites W2169664803 @default.
• W2059383510 cites W79615464 @default.
• W2059383510 doi "https://doi.org/10.1096/fj.09-144410" @default.
• W2059383510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19880629" @default.
• W2059383510 hasPublicationYear "2009" @default.
• W2059383510 type Work @default.
• W2059383510 sameAs 2059383510 @default.
• W2059383510 citedByCount "81" @default.
• W2059383510 countsByYear W20593835102012 @default.
• W2059383510 countsByYear W20593835102013 @default.
• W2059383510 countsByYear W20593835102014 @default.
• W2059383510 countsByYear W20593835102015 @default.
• W2059383510 countsByYear W20593835102016 @default.
• W2059383510 countsByYear W20593835102017 @default.
• W2059383510 countsByYear W20593835102018 @default.
• W2059383510 countsByYear W20593835102019 @default.
• W2059383510 countsByYear W20593835102020 @default.
• W2059383510 countsByYear W20593835102021 @default.
• W2059383510 countsByYear W20593835102022 @default.
• W2059383510 countsByYear W20593835102023 @default.
• W2059383510 crossrefType "journal-article" @default.
• W2059383510 hasAuthorship W2059383510A5039398608 @default.
• W2059383510 hasAuthorship W2059383510A5062502288 @default.
• W2059383510 hasConcept C104317684 @default.
• W2059383510 hasConcept C126322002 @default.
• W2059383510 hasConcept C134018914 @default.
• W2059383510 hasConcept C135763542 @default.
• W2059383510 hasConcept C150903083 @default.
• W2059383510 hasConcept C181199279 @default.
• W2059383510 hasConcept C185592680 @default.
• W2059383510 hasConcept C207001950 @default.
• W2059383510 hasConcept C2776509667 @default.
• W2059383510 hasConcept C2777090595 @default.
• W2059383510 hasConcept C37501387 @default.
• W2059383510 hasConcept C55493867 @default.
• W2059383510 hasConcept C71924100 @default.
• W2059383510 hasConcept C86803240 @default.
• W2059383510 hasConceptScore W2059383510C104317684 @default.
• W2059383510 hasConceptScore W2059383510C126322002 @default.
• W2059383510 hasConceptScore W2059383510C134018914 @default.
• W2059383510 hasConceptScore W2059383510C135763542 @default.
• W2059383510 hasConceptScore W2059383510C150903083 @default.
• W2059383510 hasConceptScore W2059383510C181199279 @default.
• W2059383510 hasConceptScore W2059383510C185592680 @default.
• W2059383510 hasConceptScore W2059383510C207001950 @default.
• W2059383510 hasConceptScore W2059383510C2776509667 @default.
• W2059383510 hasConceptScore W2059383510C2777090595 @default.
• W2059383510 hasConceptScore W2059383510C37501387 @default.
• W2059383510 hasConceptScore W2059383510C55493867 @default.
• W2059383510 hasConceptScore W2059383510C71924100 @default.
• W2059383510 hasConceptScore W2059383510C86803240 @default.
• W2059383510 hasFunder F4320306230 @default.
• W2059383510 hasIssue "3" @default.
• W2059383510 hasLocation W20593835101 @default.
• W2059383510 hasLocation W20593835102 @default.

• next