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- W2059384736 abstract "The extracellular K+ concentration, [K+]e, was studied in unstimulated spinal cords in situ or in isolated spinal cords of frogs. The [K+]e in the dorsal horn at a depth of 150-500 microM exceeded the [K+]e found in the submeningeal fluid, in most of the upper dorsal horn and in the ventral horn by as much as 2.0 mmol . 1(-1). A substantially higher [K+]e, by 0.5-1.0 mmol . 1(-1) was also found in the intermediate region. The blockade of synaptic activity and of spontaneous activity in isolated spinal cords superfused by Ringer solution with high Mg2+ or Mn2+ concentrations decreased [K+]e in the dorsal horn and intermediate region to about 3.0 mmol . 1(-1). Similarly, the increase of spontaneous activity evoked in the isolated cords by changing the temperature of the Ringer solution, was associated with an increase of [K+]e in the dorsal spinal horn. The data suggest that the high [K+]e in the unstimulated dorsal horn results from K+ accumulation during spontaneous activity of interneurones, and its possible physiological role is discussed." @default.
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- W2059384736 date "1983-12-01" @default.
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- W2059384736 title "Elevated extracellular potassium concentration in unstimulated spinal dorsal horns of frogs" @default.
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- W2059384736 doi "https://doi.org/10.1016/0304-3940(83)90203-3" @default.
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