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• W2059387584 abstract "We investigated the effects of platelet supernatant on pressor responses to norepinephrine in isolated perfused rat mesenteric arteries. Perfusion of the arteries with platelet supernatant for 2 h markedly enhanced the pressor responses to norepinephrine (10−6 and 3×10−6 M). This enhancement was significantly inhibited by phosphoramidon (10−4 M), an endothelin converting enzyme inhibitor. Both BQ788 [N-cis-2,6-dimethylpiperidinocarbonyl-l-γ-methylleucyl-d-1-methoxycarbonyltryptophanyl-d-norleucine] (10−6 M), an endothelin ETB receptor antagonist, and bosentan (Ro47-0203, 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2,2́-bipyrimidin-4-yl]-benzenesulfonamide) (10−5 M), a nonselective endothelin receptor antagonist, also prevented the potentiation of responses to norepinephrine evoked by platelet supernatant, but FR139317 ((R)2-[(R)-2-[(S)-2-[[1-(hexahydro-1H-azepinyl)]carbonyl]amino-4-methyl-pentanoyl] amino-3-[3-(1-methyl-1H-indoyl)]propionyl]amino-3-(2-pyridyl) propionic acid) (10−6 M), an endothelin ETA receptor antagonist, had little effect. Suppressor doses of endothelin-1 (3×10−10 M) or sarafotoxin S6c (S6c) (3×10−10 M) potentiated significantly the norepinephrine-induced vasoconstriction, in the same preparation. Moreover, supernatant-induced enhancement of pressor responses to norepinephrine was markedly suppressed by TGF-β1 neutralizing antibody. Transforming growth factor-β1 (TGF-β1) (40 pM) also significantly enhanced the pressor responses to norepinephrine (10−6 M) and this enhancement was significantly inhibited by phosphoramidon. These results suggest that platelet-derived TGF-β1 stimulates the vascular production of endothelin-1 and thereby enhances vasoconstrictor responses to norepinephrine. Platelet-induced enhancement of vasoconstrictor responses to norepinephrine seems to be mainly mediated by endothelin ETB receptor, in rat mesenteric arteries." @default.
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• W2059387584 date "1997-12-01" @default.
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• W2059387584 title "Platelets enhance contractility in perfused rat mesenteric arteries: Involvement of endothelin-1" @default.
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• W2059387584 doi "https://doi.org/10.1016/s0014-2999(97)01429-5" @default.
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