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- W2059390362 abstract "The p53 tumor suppressor protein is critically involved in cell cycle regulation and programmed cell death. Here we show that expression of the BH3-only protein ITM2Bs is able to induce apoptotic cell death in p53+/+, as well as in p53-/- cell lines. This cell death involves neither subcellular redistribution of p53 nor transcriptional regulation of p53 target genes such as Bax, Ras, Puma or Bcl-2. Together, our data provide evidence for a p53-independent apoptotic role of ITM2Bs." @default.
- W2059390362 created "2016-06-24" @default.
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- W2059390362 date "2004-01-07" @default.
- W2059390362 modified "2023-10-10" @default.
- W2059390362 title "Induction of p53‐independent apoptosis by the BH3‐only protein ITM2Bs" @default.
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- W2059390362 doi "https://doi.org/10.1016/s0014-5793(03)01519-9" @default.
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