FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059391489> ?p ?o ?g. }

• W2059391489 endingPage "409" @default.
• W2059391489 startingPage "404" @default.
• W2059391489 abstract "Hydrocodone combined with acetaminophen is commonly used for moderate pain. Hydrocodone is metabolized by cytochrome P450 (CYP) 2D6 into hydromorphone and by CYP3A4 into norhydrocodone. This was a retrospective study evaluating hydrocodone, hydromorphone and norhydrocodone distributions in urine. Urine specimens (n = 76,924) were obtained from patients on chronic opioid therapy during their first or single visit and were analyzed by liquid chromatography–tandem mass spectrometry (LC–MS-MS). The patients were at least 16 years of age and had documented hydrocodone use via a medication list. There were 48,710 specimens that were positive for all three analytes. Mean hydrocodone, hydromorphone and norhydrocodone mole fractions (95% confidence interval) were 0.39 (0.38–0.39), 0.12 (0.11–0.12) and 0.49 (0.48–0.49), respectively. Hydromorphone fractions were lower in women compared with men (0.11 versus 0.13; P < 0.0001). Hydrocodone mole fractions were higher in the 65-year and older age group compared with the 16- to 39-year age group (0.4 versus 0.36; P ≤ 0.005). Concurrent use of a CYP2D6 and/or CYP3A4 inhibitor altered hydromorphone and norhydrocodone mole fractions, compared with the control group. Patient factors affect hydrocodone and metabolite mole fractions and suggest increased awareness of their contribution when attempting to interpret urine drug testing results." @default.
• W2059391489 created "2016-06-24" @default.
• W2059391489 creator A5012557085 @default.
• W2059391489 creator A5051905085 @default.
• W2059391489 creator A5063845737 @default.
• W2059391489 creator A5081233385 @default.
• W2059391489 date "2014-05-17" @default.
• W2059391489 modified "2023-10-18" @default.
• W2059391489 title "Urinary Hydrocodone and Metabolite Distributions in Pain Patients" @default.
• W2059391489 cites W1510717844 @default.
• W2059391489 cites W1869362176 @default.
• W2059391489 cites W1971559706 @default.
• W2059391489 cites W1997538585 @default.
• W2059391489 cites W2008637373 @default.
• W2059391489 cites W2019635687 @default.
• W2059391489 cites W2024913341 @default.
• W2059391489 cites W203684405 @default.
• W2059391489 cites W2047865790 @default.
• W2059391489 cites W2049137269 @default.
• W2059391489 cites W2051175627 @default.
• W2059391489 cites W2052517422 @default.
• W2059391489 cites W2055936731 @default.
• W2059391489 cites W2062935033 @default.
• W2059391489 cites W2064792065 @default.
• W2059391489 cites W2073232204 @default.
• W2059391489 cites W2080228333 @default.
• W2059391489 cites W2092829505 @default.
• W2059391489 cites W2099007848 @default.
• W2059391489 cites W2108226004 @default.
• W2059391489 cites W2109649983 @default.
• W2059391489 cites W2122432309 @default.
• W2059391489 cites W2122571407 @default.
• W2059391489 cites W2127660956 @default.
• W2059391489 cites W2144266470 @default.
• W2059391489 cites W2154362047 @default.
• W2059391489 cites W2168922330 @default.
• W2059391489 cites W2170430635 @default.
• W2059391489 cites W2248152105 @default.
• W2059391489 doi "https://doi.org/10.1093/jat/bku051" @default.
• W2059391489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24836897" @default.
• W2059391489 hasPublicationYear "2014" @default.
• W2059391489 type Work @default.
• W2059391489 sameAs 2059391489 @default.
• W2059391489 citedByCount "13" @default.
• W2059391489 countsByYear W20593914892016 @default.
• W2059391489 countsByYear W20593914892018 @default.
• W2059391489 countsByYear W20593914892021 @default.
• W2059391489 countsByYear W20593914892022 @default.
• W2059391489 countsByYear W20593914892023 @default.
• W2059391489 crossrefType "journal-article" @default.
• W2059391489 hasAuthorship W2059391489A5012557085 @default.
• W2059391489 hasAuthorship W2059391489A5051905085 @default.
• W2059391489 hasAuthorship W2059391489A5063845737 @default.
• W2059391489 hasAuthorship W2059391489A5081233385 @default.
• W2059391489 hasBestOaLocation W20593914891 @default.
• W2059391489 hasConcept C126322002 @default.
• W2059391489 hasConcept C126894567 @default.
• W2059391489 hasConcept C170493617 @default.
• W2059391489 hasConcept C185592680 @default.
• W2059391489 hasConcept C2776029756 @default.
• W2059391489 hasConcept C2776389719 @default.
• W2059391489 hasConcept C2777477808 @default.
• W2059391489 hasConcept C2779158186 @default.
• W2059391489 hasConcept C2780026642 @default.
• W2059391489 hasConcept C2781063702 @default.
• W2059391489 hasConcept C42219234 @default.
• W2059391489 hasConcept C71924100 @default.
• W2059391489 hasConceptScore W2059391489C126322002 @default.
• W2059391489 hasConceptScore W2059391489C126894567 @default.
• W2059391489 hasConceptScore W2059391489C170493617 @default.
• W2059391489 hasConceptScore W2059391489C185592680 @default.
• W2059391489 hasConceptScore W2059391489C2776029756 @default.
• W2059391489 hasConceptScore W2059391489C2776389719 @default.
• W2059391489 hasConceptScore W2059391489C2777477808 @default.
• W2059391489 hasConceptScore W2059391489C2779158186 @default.
• W2059391489 hasConceptScore W2059391489C2780026642 @default.
• W2059391489 hasConceptScore W2059391489C2781063702 @default.
• W2059391489 hasConceptScore W2059391489C42219234 @default.
• W2059391489 hasConceptScore W2059391489C71924100 @default.
• W2059391489 hasIssue "7" @default.
• W2059391489 hasLocation W20593914891 @default.
• W2059391489 hasLocation W20593914892 @default.
• W2059391489 hasLocation W20593914893 @default.
• W2059391489 hasOpenAccess W2059391489 @default.
• W2059391489 hasPrimaryLocation W20593914891 @default.
• W2059391489 hasRelatedWork W1826791800 @default.
• W2059391489 hasRelatedWork W2021281327 @default.
• W2059391489 hasRelatedWork W2033791342 @default.
• W2059391489 hasRelatedWork W2086752116 @default.
• W2059391489 hasRelatedWork W2117191402 @default.
• W2059391489 hasRelatedWork W2132327370 @default.
• W2059391489 hasRelatedWork W2941629973 @default.
• W2059391489 hasRelatedWork W2977187351 @default.
• W2059391489 hasRelatedWork W3021830480 @default.
• W2059391489 hasRelatedWork W4280491243 @default.
• W2059391489 hasVolume "38" @default.
• W2059391489 isParatext "false" @default.
• W2059391489 isRetracted "false" @default.

• next