FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059393907> ?p ?o ?g. }

• W2059393907 endingPage "215" @default.
• W2059393907 startingPage "209" @default.
• W2059393907 abstract "The most important aim in controlling virus infections is to destroy infected cells. Impaired cellular immunity in HIV and HCV infection leads to chronic infection. This study examined the effect of cytapheresis on the subsequent response to interferon/ribavirin treatment in patients infected with HCV. Adacolumn® cytapheresis was carried out once a day for 5 consecutive days in patients who relapsed or did not respond to previous peginterferon and ribavirin combination treatment (n = 14: relapsers = 3, non-responders = 11). Peginterferon and ribavirin combination treatment was started after cytapheresis. During combination treatment, the proliferative response of peripheral blood mononuclear cells to HCV proteins (core, NS3, NS4, and NS5), tetanus toxoid, and phytohemagglutinin was measured, and compared to the early virological response. After treatment by leucocytapheresis, the proliferative response of peripheral blood mononuclear cells to HCV-core and tetanus toxoid increased significantly over the baseline (P < 0.05). A marked increase in the phytohemagglutinin response was observed after peginterferon and ribavirin combination treatment was started (P < 0.01 at week 5 and P < 0.005 at week 13). There were, however, no clear changes in the proliferative response to other antigens. Among the 14 patients, 12 (85.7%) achieved an early virological response by week 13 (12 weeks after the start of combination treatment). After treatment, nine patients (64.3%) had a significant proliferative response to HCV core antigen. Among the nine patients, eight patients (88.9%) achieved early virological response. The results indicate that activation of cellular immunity by leucocytapheresis facilitates an early virological response rate in HCV patients. This new therapy may, therefore, become an additional therapeutic measure for HCV. J. Med. Virol. 77:209–215, 2005. © 2005 Wiley-Liss, Inc." @default.
• W2059393907 created "2016-06-24" @default.
• W2059393907 creator A5010474616 @default.
• W2059393907 creator A5014615779 @default.
• W2059393907 creator A5016716688 @default.
• W2059393907 creator A5019641065 @default.
• W2059393907 creator A5044524026 @default.
• W2059393907 creator A5046297391 @default.
• W2059393907 creator A5070805632 @default.
• W2059393907 date "2005-01-01" @default.
• W2059393907 modified "2023-10-18" @default.
• W2059393907 title "Leucoytapheresis with Adacolumn® enhances HCV-specific proliferative responses in patients infected with hepatitis C virus genotype 1" @default.
• W2059393907 cites W1600501096 @default.
• W2059393907 cites W1966743970 @default.
• W2059393907 cites W1972375090 @default.
• W2059393907 cites W1983657144 @default.
• W2059393907 cites W1987090812 @default.
• W2059393907 cites W1990058709 @default.
• W2059393907 cites W1991454586 @default.
• W2059393907 cites W1992239172 @default.
• W2059393907 cites W1998669743 @default.
• W2059393907 cites W2007434359 @default.
• W2059393907 cites W2012845141 @default.
• W2059393907 cites W2023291476 @default.
• W2059393907 cites W2024627663 @default.
• W2059393907 cites W2028789314 @default.
• W2059393907 cites W2043519223 @default.
• W2059393907 cites W2047711008 @default.
• W2059393907 cites W2049583989 @default.
• W2059393907 cites W2075915057 @default.
• W2059393907 cites W2078856942 @default.
• W2059393907 cites W2093514179 @default.
• W2059393907 cites W2102554377 @default.
• W2059393907 cites W2115281102 @default.
• W2059393907 cites W2128588668 @default.
• W2059393907 cites W2131390487 @default.
• W2059393907 cites W2143904760 @default.
• W2059393907 cites W2169406601 @default.
• W2059393907 cites W317206593 @default.
• W2059393907 cites W324347931 @default.
• W2059393907 doi "https://doi.org/10.1002/jmv.20437" @default.
• W2059393907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16121358" @default.
• W2059393907 hasPublicationYear "2005" @default.
• W2059393907 type Work @default.
• W2059393907 sameAs 2059393907 @default.
• W2059393907 citedByCount "7" @default.
• W2059393907 countsByYear W20593939072014 @default.
• W2059393907 countsByYear W20593939072016 @default.
• W2059393907 countsByYear W20593939072021 @default.
• W2059393907 crossrefType "journal-article" @default.
• W2059393907 hasAuthorship W2059393907A5010474616 @default.
• W2059393907 hasAuthorship W2059393907A5014615779 @default.
• W2059393907 hasAuthorship W2059393907A5016716688 @default.
• W2059393907 hasAuthorship W2059393907A5019641065 @default.
• W2059393907 hasAuthorship W2059393907A5044524026 @default.
• W2059393907 hasAuthorship W2059393907A5046297391 @default.
• W2059393907 hasAuthorship W2059393907A5070805632 @default.
• W2059393907 hasConcept C126322002 @default.
• W2059393907 hasConcept C137061746 @default.
• W2059393907 hasConcept C147483822 @default.
• W2059393907 hasConcept C159047783 @default.
• W2059393907 hasConcept C202751555 @default.
• W2059393907 hasConcept C203014093 @default.
• W2059393907 hasConcept C22070199 @default.
• W2059393907 hasConcept C2522874641 @default.
• W2059393907 hasConcept C2776178377 @default.
• W2059393907 hasConcept C2776408679 @default.
• W2059393907 hasConcept C2777351567 @default.
• W2059393907 hasConcept C2779841045 @default.
• W2059393907 hasConcept C2780040827 @default.
• W2059393907 hasConcept C3017875465 @default.
• W2059393907 hasConcept C55493867 @default.
• W2059393907 hasConcept C71924100 @default.
• W2059393907 hasConcept C86803240 @default.
• W2059393907 hasConceptScore W2059393907C126322002 @default.
• W2059393907 hasConceptScore W2059393907C137061746 @default.
• W2059393907 hasConceptScore W2059393907C147483822 @default.
• W2059393907 hasConceptScore W2059393907C159047783 @default.
• W2059393907 hasConceptScore W2059393907C202751555 @default.
• W2059393907 hasConceptScore W2059393907C203014093 @default.
• W2059393907 hasConceptScore W2059393907C22070199 @default.
• W2059393907 hasConceptScore W2059393907C2522874641 @default.
• W2059393907 hasConceptScore W2059393907C2776178377 @default.
• W2059393907 hasConceptScore W2059393907C2776408679 @default.
• W2059393907 hasConceptScore W2059393907C2777351567 @default.
• W2059393907 hasConceptScore W2059393907C2779841045 @default.
• W2059393907 hasConceptScore W2059393907C2780040827 @default.
• W2059393907 hasConceptScore W2059393907C3017875465 @default.
• W2059393907 hasConceptScore W2059393907C55493867 @default.
• W2059393907 hasConceptScore W2059393907C71924100 @default.
• W2059393907 hasConceptScore W2059393907C86803240 @default.
• W2059393907 hasIssue "2" @default.
• W2059393907 hasLocation W20593939071 @default.
• W2059393907 hasLocation W20593939072 @default.
• W2059393907 hasOpenAccess W2059393907 @default.
• W2059393907 hasPrimaryLocation W20593939071 @default.
• W2059393907 hasRelatedWork W1522397301 @default.
• W2059393907 hasRelatedWork W1974593262 @default.

• next