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• W2059402303 abstract "Objective: The aim of this study was to report our experience and review the literature on brain metastases from malignant germ cell tumors (MGCTs) of the testis in order to characterize the clinical features of this disease. Patients and Methods: Between 1993 and 2007, 92 patients with metastatic MGCT were treated at our institution. Of these 92 patients, 5 developed brain metastases and are included in this study. The clinicopathological features of these 5 patients were retrospectively analyzed with reference to previously reported studies focusing on brain metastasis from MGCTs of the testis. Results: Brain metastases were diagnosed at presentation in 1 patient, following complete remission in 1 patient, or along with extra-cerebral tumor progression in 3 patients. All 5 patients presented some symptoms suggesting the presence of intracranial disease, and had bulky thoracic disease. After detecting brain metastases, 2 patients had only radiotherapy, 1 patient had chemotherapy plus radiotherapy, 1 patient received chemotherapy, radiotherapy, plus surgery; however, the remaining patient did not receive any treatments because of a poor general condition associated with brain hemorrhage from the metastatic lesions. Three of the 5 patients died 1, 3 and 4 months after the diagnosis of brain metastases, while the remaining 2 were alive with no evidence of disease 41 and 15 months after the completion of treatments. Conclusion: Considering the current data as well as the literature, the prognosis of patients with brain metastases is extremely poor; therefore, routine cranial imaging should be performed in patients with advanced tes-ticular MGCT, particularly those with bulky thoracic disease." @default.
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• W2059402303 date "2008-05-01" @default.
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• W2059402303 title "Brain Metastases from Malignant Germ Cell Tumors of the Testis: Our Experience of 5 Cases with a Review of the Literature" @default.
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• W2059402303 doi "https://doi.org/10.1159/000115383" @default.
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