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• W2059413146 abstract "Protease digestion of the herpes simplex virus type 1 major single-strand DNA binding protein ICP8 showed that the cleavage patterns observed in the presence and absence of single-stranded DNA oligonucleotides are substantially different with protection of cleavage sites between amino acids 293 and 806 observed in the presence of oligonucleotide. Experiments using ICP8 modified with fluorescein-5-maleimide (FM) showed that the fluorescence signal exhibited increased susceptibility to antibody quenching and a significant decrease in polarization of the FM fluorescence was observed in the presence compared to the absence of oligonucleotide. Taken together, these results indicate that ICP8 undergoes a conformational change upon binding to single-stranded DNA." @default.
• W2059413146 created "2016-06-24" @default.
• W2059413146 creator A5019812060 @default.
• W2059413146 creator A5058115246 @default.
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• W2059413146 date "2001-10-01" @default.
• W2059413146 modified "2023-09-27" @default.
• W2059413146 title "Conformational Change in the Herpes Simplex Single-Strand Binding Protein Induced by DNA" @default.
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• W2059413146 doi "https://doi.org/10.1006/bbrc.2001.5766" @default.
• W2059413146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11594771" @default.
• W2059413146 hasPublicationYear "2001" @default.
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