FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059414323> ?p ?o ?g. }

• W2059414323 endingPage "86.e12" @default.
• W2059414323 startingPage "86.e1" @default.
• W2059414323 abstract "Objective Clinical management of preeclampsia has remained unchanged for almost 5 decades. We now understand that maternal endothelial dysfunction likely arises because of placenta-derived vasoactive factors. Activin A is one such antiangiogenic factor that is released by the placenta and that is elevated in maternal serum in women with preeclampsia. Whether activin has a role in the pathogenesis of preeclampsia is not known. Study Design To assess the effects of activin on endothelial cell function, we cultured human umbilical vein endothelial cells in the presence of activin or serum from normal pregnant women or pregnant women with preeclampsia, with or without follistatin, a functional activin antagonist or apocynin, a NADPH oxidase (Nox2) inhibitor. We also administered activin to pregnant C57Bl6 mice, with or without apocynin, and studied maternal and fetal outcomes. Last, we assessed endothelial cell Nox2 and nitric oxide synthase expression in normal pregnant women and pregnant women with preeclampsia. Results Activin and preeclamptic serum induced endothelial cell oxidative stress by Nox2 up-regulation and endothelial cell dysfunction, which are effects that are mitigated by either follistatin or apocynin. The administration of activin to pregnant mice induced endothelial oxidative stress, hypertension, proteinuria, fetal growth restriction, and preterm littering. Apocynin prevented all of these effects. Compared with normal pregnant women, women with preeclampsia had increased endothelial Nox2 expression. Conclusion An activin-Nox2 pathway is a likely link between an injured placenta, endothelial dysfunction, and preeclampsia. This offers opportunities that are not novel therapeutic approaches to preeclampsia. Clinical management of preeclampsia has remained unchanged for almost 5 decades. We now understand that maternal endothelial dysfunction likely arises because of placenta-derived vasoactive factors. Activin A is one such antiangiogenic factor that is released by the placenta and that is elevated in maternal serum in women with preeclampsia. Whether activin has a role in the pathogenesis of preeclampsia is not known. To assess the effects of activin on endothelial cell function, we cultured human umbilical vein endothelial cells in the presence of activin or serum from normal pregnant women or pregnant women with preeclampsia, with or without follistatin, a functional activin antagonist or apocynin, a NADPH oxidase (Nox2) inhibitor. We also administered activin to pregnant C57Bl6 mice, with or without apocynin, and studied maternal and fetal outcomes. Last, we assessed endothelial cell Nox2 and nitric oxide synthase expression in normal pregnant women and pregnant women with preeclampsia. Activin and preeclamptic serum induced endothelial cell oxidative stress by Nox2 up-regulation and endothelial cell dysfunction, which are effects that are mitigated by either follistatin or apocynin. The administration of activin to pregnant mice induced endothelial oxidative stress, hypertension, proteinuria, fetal growth restriction, and preterm littering. Apocynin prevented all of these effects. Compared with normal pregnant women, women with preeclampsia had increased endothelial Nox2 expression. An activin-Nox2 pathway is a likely link between an injured placenta, endothelial dysfunction, and preeclampsia. This offers opportunities that are not novel therapeutic approaches to preeclampsia." @default.
• W2059414323 created "2016-06-24" @default.
• W2059414323 creator A5000898704 @default.
• W2059414323 creator A5008343091 @default.
• W2059414323 creator A5017988097 @default.
• W2059414323 creator A5048373566 @default.
• W2059414323 creator A5051677621 @default.
• W2059414323 creator A5064439771 @default.
• W2059414323 creator A5082142817 @default.
• W2059414323 date "2015-01-01" @default.
• W2059414323 modified "2023-10-11" @default.
• W2059414323 title "Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies" @default.
• W2059414323 cites W1983687348 @default.
• W2059414323 cites W1984970610 @default.
• W2059414323 cites W1985379157 @default.
• W2059414323 cites W1990199612 @default.
• W2059414323 cites W2007942310 @default.
• W2059414323 cites W2014477968 @default.
• W2059414323 cites W2022620832 @default.
• W2059414323 cites W2024340931 @default.
• W2059414323 cites W2028835073 @default.
• W2059414323 cites W2031193867 @default.
• W2059414323 cites W2043804359 @default.
• W2059414323 cites W2044058764 @default.
• W2059414323 cites W2070216509 @default.
• W2059414323 cites W2070588731 @default.
• W2059414323 cites W2073371406 @default.
• W2059414323 cites W2073748990 @default.
• W2059414323 cites W2083199194 @default.
• W2059414323 cites W2084983662 @default.
• W2059414323 cites W2085321659 @default.
• W2059414323 cites W2086073438 @default.
• W2059414323 cites W2086576477 @default.
• W2059414323 cites W2095014707 @default.
• W2059414323 cites W2102619095 @default.
• W2059414323 cites W2105076216 @default.
• W2059414323 cites W2105632053 @default.
• W2059414323 cites W2106287060 @default.
• W2059414323 cites W2106703642 @default.
• W2059414323 cites W2119801720 @default.
• W2059414323 cites W2120468749 @default.
• W2059414323 cites W2120600622 @default.
• W2059414323 cites W2125817440 @default.
• W2059414323 cites W2132961242 @default.
• W2059414323 cites W2137230520 @default.
• W2059414323 cites W2140011724 @default.
• W2059414323 cites W2143180984 @default.
• W2059414323 cites W2157615046 @default.
• W2059414323 cites W2162497392 @default.
• W2059414323 cites W2166406180 @default.
• W2059414323 cites W2167559287 @default.
• W2059414323 cites W4236182870 @default.
• W2059414323 cites W4243004750 @default.
• W2059414323 cites W4244433662 @default.
• W2059414323 cites W4251118184 @default.
• W2059414323 cites W4382916220 @default.
• W2059414323 cites W71395560 @default.
• W2059414323 doi "https://doi.org/10.1016/j.ajog.2014.07.021" @default.
• W2059414323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25046804" @default.
• W2059414323 hasPublicationYear "2015" @default.
• W2059414323 type Work @default.
• W2059414323 sameAs 2059414323 @default.
• W2059414323 citedByCount "56" @default.
• W2059414323 countsByYear W20594143232015 @default.
• W2059414323 countsByYear W20594143232016 @default.
• W2059414323 countsByYear W20594143232017 @default.
• W2059414323 countsByYear W20594143232018 @default.
• W2059414323 countsByYear W20594143232019 @default.
• W2059414323 countsByYear W20594143232020 @default.
• W2059414323 countsByYear W20594143232021 @default.
• W2059414323 countsByYear W20594143232022 @default.
• W2059414323 countsByYear W20594143232023 @default.
• W2059414323 crossrefType "journal-article" @default.
• W2059414323 hasAuthorship W2059414323A5000898704 @default.
• W2059414323 hasAuthorship W2059414323A5008343091 @default.
• W2059414323 hasAuthorship W2059414323A5017988097 @default.
• W2059414323 hasAuthorship W2059414323A5048373566 @default.
• W2059414323 hasAuthorship W2059414323A5051677621 @default.
• W2059414323 hasAuthorship W2059414323A5064439771 @default.
• W2059414323 hasAuthorship W2059414323A5082142817 @default.
• W2059414323 hasConcept C126322002 @default.
• W2059414323 hasConcept C134018914 @default.
• W2059414323 hasConcept C172680121 @default.
• W2059414323 hasConcept C2776151105 @default.
• W2059414323 hasConcept C2776953305 @default.
• W2059414323 hasConcept C2777209548 @default.
• W2059414323 hasConcept C2777218350 @default.
• W2059414323 hasConcept C2778831791 @default.
• W2059414323 hasConcept C2779234561 @default.
• W2059414323 hasConcept C2779719074 @default.
• W2059414323 hasConcept C2780972559 @default.
• W2059414323 hasConcept C54355233 @default.
• W2059414323 hasConcept C71924100 @default.
• W2059414323 hasConcept C86803240 @default.
• W2059414323 hasConceptScore W2059414323C126322002 @default.
• W2059414323 hasConceptScore W2059414323C134018914 @default.
• W2059414323 hasConceptScore W2059414323C172680121 @default.
• W2059414323 hasConceptScore W2059414323C2776151105 @default.

• next