Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059414390> ?p ?o ?g. }
- W2059414390 endingPage "217" @default.
- W2059414390 startingPage "208" @default.
- W2059414390 abstract "Engraftment of human embryonic stem cell (hESC)-derived OPCs in animal models of demyelination results in remyelination and clinical recovery, supporting the feasibility of cell replacement therapies in promoting repair of damaged neural tissue. A critical gap in our understanding of the mechanisms associated with repair revolves around the effects of the local microenvironment on transplanted cell survival. We have determined that treatment of human ESC-derived OPCs with the pleiotropic cytokine IFN-γ promotes apoptosis that is associated with mitochondrial cytochrome c released into the cytosol with subsequent caspase 3 activation. IFN-γ-induced apoptosis is mediated, in part, by secretion of the CXC chemokine ligand 10 (CXCL10) from IFN-γ-treated cells. Signaling through the chemokine receptor CXCR2 by the ligand CXCL1 functions in a tonic manner by muting apoptosis and this is associated with reduced levels of cytosolic cytochrome c and impaired cleavage of caspase 3. These findings support a role for both IFN-γ and CXCL10 in contributing to neuropathology by promoting OPC apoptosis. In addition, these data suggest that hOPCs used for therapeutic treatment for human neurologic disease/damage are susceptible to death through exposure to local inflammatory cytokines present within the inflammatory milieu." @default.
- W2059414390 created "2016-06-24" @default.
- W2059414390 creator A5002640166 @default.
- W2059414390 creator A5060105564 @default.
- W2059414390 creator A5063545397 @default.
- W2059414390 creator A5069110431 @default.
- W2059414390 date "2012-11-01" @default.
- W2059414390 modified "2023-09-23" @default.
- W2059414390 title "IFN-γ-induced apoptosis of human embryonic stem cell derived oligodendrocyte progenitor cells is restricted by CXCR2 signaling" @default.
- W2059414390 cites W1481786375 @default.
- W2059414390 cites W1483336751 @default.
- W2059414390 cites W1528069886 @default.
- W2059414390 cites W1550129999 @default.
- W2059414390 cites W1599568627 @default.
- W2059414390 cites W1657790903 @default.
- W2059414390 cites W1849944071 @default.
- W2059414390 cites W1892477107 @default.
- W2059414390 cites W1965759558 @default.
- W2059414390 cites W1973854653 @default.
- W2059414390 cites W1976180595 @default.
- W2059414390 cites W1976812575 @default.
- W2059414390 cites W1987464002 @default.
- W2059414390 cites W1991063345 @default.
- W2059414390 cites W1995275667 @default.
- W2059414390 cites W1998761401 @default.
- W2059414390 cites W2004775355 @default.
- W2059414390 cites W2006254036 @default.
- W2059414390 cites W2007990382 @default.
- W2059414390 cites W2012814330 @default.
- W2059414390 cites W2014497160 @default.
- W2059414390 cites W2018266237 @default.
- W2059414390 cites W2021941118 @default.
- W2059414390 cites W2025797605 @default.
- W2059414390 cites W2028543273 @default.
- W2059414390 cites W2038757125 @default.
- W2059414390 cites W2045281561 @default.
- W2059414390 cites W2046216114 @default.
- W2059414390 cites W2046230726 @default.
- W2059414390 cites W2048082433 @default.
- W2059414390 cites W2048684002 @default.
- W2059414390 cites W2050597784 @default.
- W2059414390 cites W2063406878 @default.
- W2059414390 cites W2071674387 @default.
- W2059414390 cites W2073005183 @default.
- W2059414390 cites W2074718706 @default.
- W2059414390 cites W2075515301 @default.
- W2059414390 cites W2080678920 @default.
- W2059414390 cites W2086196933 @default.
- W2059414390 cites W2086427126 @default.
- W2059414390 cites W2088124775 @default.
- W2059414390 cites W2088258412 @default.
- W2059414390 cites W2090028614 @default.
- W2059414390 cites W2099088088 @default.
- W2059414390 cites W2102870728 @default.
- W2059414390 cites W2113291839 @default.
- W2059414390 cites W2113874469 @default.
- W2059414390 cites W2123255618 @default.
- W2059414390 cites W2124458297 @default.
- W2059414390 cites W2130487801 @default.
- W2059414390 cites W2132670847 @default.
- W2059414390 cites W2146241894 @default.
- W2059414390 cites W2149226616 @default.
- W2059414390 cites W2153286899 @default.
- W2059414390 cites W2158704188 @default.
- W2059414390 cites W2168579634 @default.
- W2059414390 cites W2290912611 @default.
- W2059414390 cites W2321850203 @default.
- W2059414390 cites W2410788664 @default.
- W2059414390 cites W4300542283 @default.
- W2059414390 cites W86059255 @default.
- W2059414390 doi "https://doi.org/10.1016/j.scr.2012.06.005" @default.
- W2059414390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22885102" @default.
- W2059414390 hasPublicationYear "2012" @default.
- W2059414390 type Work @default.
- W2059414390 sameAs 2059414390 @default.
- W2059414390 citedByCount "24" @default.
- W2059414390 countsByYear W20594143902013 @default.
- W2059414390 countsByYear W20594143902014 @default.
- W2059414390 countsByYear W20594143902015 @default.
- W2059414390 countsByYear W20594143902016 @default.
- W2059414390 countsByYear W20594143902018 @default.
- W2059414390 countsByYear W20594143902019 @default.
- W2059414390 countsByYear W20594143902020 @default.
- W2059414390 countsByYear W20594143902021 @default.
- W2059414390 countsByYear W20594143902022 @default.
- W2059414390 crossrefType "journal-article" @default.
- W2059414390 hasAuthorship W2059414390A5002640166 @default.
- W2059414390 hasAuthorship W2059414390A5060105564 @default.
- W2059414390 hasAuthorship W2059414390A5063545397 @default.
- W2059414390 hasAuthorship W2059414390A5069110431 @default.
- W2059414390 hasConcept C104317684 @default.
- W2059414390 hasConcept C12823836 @default.
- W2059414390 hasConcept C13373296 @default.
- W2059414390 hasConcept C145103041 @default.
- W2059414390 hasConcept C190283241 @default.
- W2059414390 hasConcept C201750760 @default.
- W2059414390 hasConcept C203014093 @default.
- W2059414390 hasConcept C2776914184 @default.