FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059423488> ?p ?o ?g. }

• W2059423488 endingPage "4020" @default.
• W2059423488 startingPage "4011" @default.
• W2059423488 abstract "Calcium-containing calmodulin (CaM) and its complex with a peptide corresponding to the calmodulin-binding domain of skeletal muscle myosin light chain kinase [skMLCK(576-594)G] have been studied by one- and two-dimensional 1H NMR techniques. Resonances arising from the antiparallel beta-sheet structures associated with the calcium-binding domains of CaM and their counterparts in the CaM-skMLCK(576-594)G complex have been assigned. The assignments were initiated by application of the main chain directed assignment strategy. It is found that, despite significant changes in chemical shifts of resonances arising from amino acid residues in this region upon binding of the peptide, the beta-sheets have virtually the same structure in the complex as in CaM. Hydrogen exchange rates of amide NH within the beta-sheet structures are significantly slowed upon binding of peptide. These data, in conjunction with the observed nuclear Overhauser effect (NOE) patterns and relative intensities and the downfield shifts of associated amide and alpha resonances upon binding of peptide, show that the peptide stabilizes the Ca2+-bound state of calmodulin. The observed pattern of NOEs within the beta-sheets and their structural similarity correspond closely to those predicted by the crystal structure. These findings imply that the apparent inconsistency of the crystal structure with recently reported low-angle X-ray scattering profiles of CaM may lie within the putative central helix bridging the globular domains." @default.
• W2059423488 created "2016-06-24" @default.
• W2059423488 creator A5062942186 @default.
• W2059423488 creator A5081320421 @default.
• W2059423488 date "1989-05-02" @default.
• W2059423488 modified "2023-10-17" @default.
• W2059423488 title "Structural characterization of the interactions between calmodulin and skeletal muscle myosin light chain kinase: effect of peptide (576-594)G binding on the calcium-binding domains" @default.
• W2059423488 cites W13699878 @default.
• W2059423488 cites W14126152 @default.
• W2059423488 cites W1598745912 @default.
• W2059423488 cites W1765824922 @default.
• W2059423488 cites W1894994468 @default.
• W2059423488 cites W1970304024 @default.
• W2059423488 cites W1978743038 @default.
• W2059423488 cites W1985655894 @default.
• W2059423488 cites W1990725643 @default.
• W2059423488 cites W1993844842 @default.
• W2059423488 cites W2000401044 @default.
• W2059423488 cites W2000478781 @default.
• W2059423488 cites W2004354100 @default.
• W2059423488 cites W2013288763 @default.
• W2059423488 cites W2018336870 @default.
• W2059423488 cites W2019493296 @default.
• W2059423488 cites W2020764557 @default.
• W2059423488 cites W2027094377 @default.
• W2059423488 cites W2030901966 @default.
• W2059423488 cites W2037710668 @default.
• W2059423488 cites W2040695109 @default.
• W2059423488 cites W2042748946 @default.
• W2059423488 cites W2053591536 @default.
• W2059423488 cites W2054123691 @default.
• W2059423488 cites W2059782931 @default.
• W2059423488 cites W2062972508 @default.
• W2059423488 cites W2063150400 @default.
• W2059423488 cites W2066164268 @default.
• W2059423488 cites W2088588907 @default.
• W2059423488 cites W2090461679 @default.
• W2059423488 cites W2093689465 @default.
• W2059423488 cites W2093700493 @default.
• W2059423488 cites W2094360908 @default.
• W2059423488 cites W2143941435 @default.
• W2059423488 cites W2253286196 @default.
• W2059423488 cites W4071648 @default.
• W2059423488 doi "https://doi.org/10.1021/bi00435a057" @default.
• W2059423488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2752005" @default.
• W2059423488 hasPublicationYear "1989" @default.
• W2059423488 type Work @default.
• W2059423488 sameAs 2059423488 @default.
• W2059423488 citedByCount "43" @default.
• W2059423488 countsByYear W20594234882015 @default.
• W2059423488 countsByYear W20594234882017 @default.
• W2059423488 crossrefType "journal-article" @default.
• W2059423488 hasAuthorship W2059423488A5062942186 @default.
• W2059423488 hasAuthorship W2059423488A5081320421 @default.
• W2059423488 hasConcept C104317684 @default.
• W2059423488 hasConcept C107824862 @default.
• W2059423488 hasConcept C115260700 @default.
• W2059423488 hasConcept C121332964 @default.
• W2059423488 hasConcept C12554922 @default.
• W2059423488 hasConcept C142089489 @default.
• W2059423488 hasConcept C159547669 @default.
• W2059423488 hasConcept C167625842 @default.
• W2059423488 hasConcept C181199279 @default.
• W2059423488 hasConcept C185592680 @default.
• W2059423488 hasConcept C25166345 @default.
• W2059423488 hasConcept C2779281246 @default.
• W2059423488 hasConcept C29688787 @default.
• W2059423488 hasConcept C42086223 @default.
• W2059423488 hasConcept C47701112 @default.
• W2059423488 hasConcept C55493867 @default.
• W2059423488 hasConcept C62520636 @default.
• W2059423488 hasConcept C6997183 @default.
• W2059423488 hasConcept C71240020 @default.
• W2059423488 hasConcept C8010536 @default.
• W2059423488 hasConcept C8035138 @default.
• W2059423488 hasConcept C86803240 @default.
• W2059423488 hasConceptScore W2059423488C104317684 @default.
• W2059423488 hasConceptScore W2059423488C107824862 @default.
• W2059423488 hasConceptScore W2059423488C115260700 @default.
• W2059423488 hasConceptScore W2059423488C121332964 @default.
• W2059423488 hasConceptScore W2059423488C12554922 @default.
• W2059423488 hasConceptScore W2059423488C142089489 @default.
• W2059423488 hasConceptScore W2059423488C159547669 @default.
• W2059423488 hasConceptScore W2059423488C167625842 @default.
• W2059423488 hasConceptScore W2059423488C181199279 @default.
• W2059423488 hasConceptScore W2059423488C185592680 @default.
• W2059423488 hasConceptScore W2059423488C25166345 @default.
• W2059423488 hasConceptScore W2059423488C2779281246 @default.
• W2059423488 hasConceptScore W2059423488C29688787 @default.
• W2059423488 hasConceptScore W2059423488C42086223 @default.
• W2059423488 hasConceptScore W2059423488C47701112 @default.
• W2059423488 hasConceptScore W2059423488C55493867 @default.
• W2059423488 hasConceptScore W2059423488C62520636 @default.
• W2059423488 hasConceptScore W2059423488C6997183 @default.
• W2059423488 hasConceptScore W2059423488C71240020 @default.
• W2059423488 hasConceptScore W2059423488C8010536 @default.
• W2059423488 hasConceptScore W2059423488C8035138 @default.
• W2059423488 hasConceptScore W2059423488C86803240 @default.

• next