FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059431092> ?p ?o ?g. }

• W2059431092 endingPage "482" @default.
• W2059431092 startingPage "459" @default.
• W2059431092 abstract "1. In order adequately to control eye movements, oculomotoneurones have to be supplied with both an eye-velocity signal and an eye-position signal. However, all the command signals of the oculomotor system are velocity signals. Nowadays, there is general agreement about the existence of a brainstem network that would convert velocity command-signals into an eye-position signal. This circuit, because of its function, is called the oculomotor neural integrator. The most obvious symptom of its eventual failure is a gaze-holding deficit: in this case, saccades are followed by a centripetal post-saccadic drift. Although the oculomotor neural integrator is central in oculomotor theory, its precise location is still a matter for debate. 2. Previously, microinjections of kainic acid (KA) into the region of the nucleus prepositus hypoglossi (NPH) and of the medial vestibular nucleus (MVN) were found to induce a horizontal gaze-holding failure both in the cat and in the monkey. However, the relatively large volumes (1-3 microliters) and concentrations (2-4 micrograms microliters-1) used in these injections made it difficult to know if the observed deficit was due to a disturbance of the NPH or of the nearby MVN. These considerations led us to inject very small amounts of kainic acid (50 nl, 0.1 microgram microliter-1) either into the rostral part of the MVN or into different sites along the NPH of the cat. 3. The search coil technique was used to record (1) spontaneous eye movements (2) the vestibulo-ocular reflex (VOR) induced by a constant-velocity rotation (50 deg s-1 for 40 s) and the optokinetic nystagmus (OKN) elicited by rotating an optokinetic drum at 30 deg s-1 for 40 s. 4. In each injection experiment, the location of the abducens nucleus of the alert cat was mapped out by recording the antidromic field potentials evoked by the stimulation of the abducens nerve. Two micropipettes were then glued together in such a way that when the tip of the recording micropipette was in the centre of the abducens nucleus the tip of the injection micropipette was in a target area. The twin pipettes were then lowered in the brainstem until the recording micropipette reached the centre of the abducens nucleus. Kainic acid was then injected into the brainstem of the alert cat through the injection micropipette by an air pressure system. 5. Carried out according to such a protocol, KA injections into the NPH or the rostral part of the MVN consistently led to specific eye-movement changes.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2059431092 created "2016-06-24" @default.
• W2059431092 creator A5051896056 @default.
• W2059431092 creator A5063406085 @default.
• W2059431092 creator A5068443919 @default.
• W2059431092 date "1993-12-01" @default.
• W2059431092 modified "2023-09-27" @default.
• W2059431092 title "Differential effect of injections of kainic acid into the prepositus and the vestibular nuclei of the cat." @default.
• W2059431092 cites W130814470 @default.
• W2059431092 cites W1764826739 @default.
• W2059431092 cites W1842711843 @default.
• W2059431092 cites W1858469235 @default.
• W2059431092 cites W1870620040 @default.
• W2059431092 cites W1928111876 @default.
• W2059431092 cites W1967567783 @default.
• W2059431092 cites W1972313558 @default.
• W2059431092 cites W1974322433 @default.
• W2059431092 cites W1974565308 @default.
• W2059431092 cites W1976218035 @default.
• W2059431092 cites W1989800526 @default.
• W2059431092 cites W1992490668 @default.
• W2059431092 cites W1996071084 @default.
• W2059431092 cites W1996608530 @default.
• W2059431092 cites W1999520388 @default.
• W2059431092 cites W1999957005 @default.
• W2059431092 cites W2000652730 @default.
• W2059431092 cites W2026305968 @default.
• W2059431092 cites W2035126207 @default.
• W2059431092 cites W2048373958 @default.
• W2059431092 cites W2054559690 @default.
• W2059431092 cites W2055636296 @default.
• W2059431092 cites W2060072391 @default.
• W2059431092 cites W2068917058 @default.
• W2059431092 cites W2070114283 @default.
• W2059431092 cites W2072195312 @default.
• W2059431092 cites W2093642963 @default.
• W2059431092 cites W2097057862 @default.
• W2059431092 cites W2115772732 @default.
• W2059431092 cites W2170907559 @default.
• W2059431092 cites W2183683480 @default.
• W2059431092 cites W2228008925 @default.
• W2059431092 cites W2265975067 @default.
• W2059431092 cites W2274591090 @default.
• W2059431092 cites W2415914040 @default.
• W2059431092 doi "https://doi.org/10.1113/jphysiol.1993.sp019956" @default.
• W2059431092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1160496" @default.
• W2059431092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8145154" @default.
• W2059431092 hasPublicationYear "1993" @default.
• W2059431092 type Work @default.
• W2059431092 sameAs 2059431092 @default.
• W2059431092 citedByCount "39" @default.
• W2059431092 countsByYear W20594310922014 @default.
• W2059431092 countsByYear W20594310922015 @default.
• W2059431092 countsByYear W20594310922016 @default.
• W2059431092 countsByYear W20594310922019 @default.
• W2059431092 countsByYear W20594310922020 @default.
• W2059431092 countsByYear W20594310922022 @default.
• W2059431092 crossrefType "journal-article" @default.
• W2059431092 hasAuthorship W2059431092A5051896056 @default.
• W2059431092 hasAuthorship W2059431092A5063406085 @default.
• W2059431092 hasAuthorship W2059431092A5068443919 @default.
• W2059431092 hasBestOaLocation W20594310922 @default.
• W2059431092 hasConcept C11054436 @default.
• W2059431092 hasConcept C121332964 @default.
• W2059431092 hasConcept C122845125 @default.
• W2059431092 hasConcept C126322002 @default.
• W2059431092 hasConcept C153050134 @default.
• W2059431092 hasConcept C15744967 @default.
• W2059431092 hasConcept C169760540 @default.
• W2059431092 hasConcept C170493617 @default.
• W2059431092 hasConcept C185592680 @default.
• W2059431092 hasConcept C190041318 @default.
• W2059431092 hasConcept C2776108384 @default.
• W2059431092 hasConcept C2776351355 @default.
• W2059431092 hasConcept C2778421575 @default.
• W2059431092 hasConcept C2780959517 @default.
• W2059431092 hasConcept C2781203944 @default.
• W2059431092 hasConcept C529278444 @default.
• W2059431092 hasConcept C551621295 @default.
• W2059431092 hasConcept C552161191 @default.
• W2059431092 hasConcept C61174792 @default.
• W2059431092 hasConcept C71924100 @default.
• W2059431092 hasConcept C83974742 @default.
• W2059431092 hasConceptScore W2059431092C11054436 @default.
• W2059431092 hasConceptScore W2059431092C121332964 @default.
• W2059431092 hasConceptScore W2059431092C122845125 @default.
• W2059431092 hasConceptScore W2059431092C126322002 @default.
• W2059431092 hasConceptScore W2059431092C153050134 @default.
• W2059431092 hasConceptScore W2059431092C15744967 @default.
• W2059431092 hasConceptScore W2059431092C169760540 @default.
• W2059431092 hasConceptScore W2059431092C170493617 @default.
• W2059431092 hasConceptScore W2059431092C185592680 @default.
• W2059431092 hasConceptScore W2059431092C190041318 @default.
• W2059431092 hasConceptScore W2059431092C2776108384 @default.
• W2059431092 hasConceptScore W2059431092C2776351355 @default.
• W2059431092 hasConceptScore W2059431092C2778421575 @default.
• W2059431092 hasConceptScore W2059431092C2780959517 @default.
• W2059431092 hasConceptScore W2059431092C2781203944 @default.

• next