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- W2059433504 abstract "Two experiments investigated a possible role of nitric oxide (NO) in chlordiazepoxide (CP)-induced feeding in nondeprived male ICR mice in independent groups designs. Experiment 1 demonstrated a dose-related decrease in CP-induced solid food intake over a 60-min test period with increasing dose (10, 25, and 50 mg/ kg SC) of the NO-synthase (NOS) inhibitor, L-NG-nitro arginine (L-NOARG), reaching statistical significance at 10 mg/kg L-NOARG when compared to vehicle control. Identical doses of L-NOARG failed to significantly affect normal feeding in vehicle treated mice. In Experiment 2, initial pretreatment with L-arginine (500 and 1000 mg/kg IP) partially or completely restored the feeding inhibitory action of a challenge dose (25 mg/kg SC) of L-NOARG; D-arginine (500 mg/kg IP) was ineffective, thus supporting a stereospecific action of arginine. Arginine isomers did not differentially affect intake in normal feeding animals. These results implicate involvement of NO in CP-induced hyperphagia; they are consistent with and extend research linking NO and ingestive behaviors." @default.
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- W2059433504 title "Possible involvement of nitric oxide in chlordiazepoxide-induced feeding in the mouse" @default.
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- W2059433504 doi "https://doi.org/10.1016/s0091-3057(96)00101-3" @default.
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