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• W2059439433 abstract "Background: The effect of cardiac resynchronization therapy (CRT) on physical function and Quality of Life (QoL) in patients who require an implantable defibrillator but do not meet guideline criteria for CRT has not been studied in detail. Methods and Results: This was a randomized study of 72 patients with high risk of sudden cardiac death, ejection fraction (EF) ≤35%, mild‐to‐moderate heart failure symptoms, and QRS > 120 ms. Patients received a CRT defibrillator and were randomized to CRT turned ON or OFF. Objective and subjective measures were performed at baseline and after 6 months. There was no difference in change in left ventricular end‐systolic volume (ESV) by radionuclid angiogram scan, the primary endpoint, between the CRT ON group (ΔESV =−7 ± 52 mL), and CRT OFF group (ΔESV =−30 ± 47 mL). Similarly, echocardiogram measures of ESV and EF showed no difference between the two groups. In the CRT ON group, selected measures of QoL and subjective exercise tolerance but not heart failure symptoms improved significantly. Six‐minute walk distance prolonged in the CRT ON group (baseline 313.6 ± 114.4 m, 6‐month 365.0 ± 122.5 m, P = 0.01), but the difference in change in walk distance between the two groups was not significant. Conclusion: Further studies with larger sample size and longer follow‐up will be required to allow definite conclusions regarding the potential benefit of CRT in this patient population." @default.
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• W2059439433 date "2009-11-16" @default.
• W2059439433 modified "2023-10-12" @default.
• W2059439433 title "Assessment of Resynchronization Therapy on Functional Status and Quality of Life in Patients Requiring an Implantable Defibrillator" @default.
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• W2059439433 doi "https://doi.org/10.1111/j.1540-8159.2009.02543.x" @default.
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