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- W2059441331 abstract "The moc1/sds23 gene was isolated to induce sexual development of a sterile strain due to overexpression of adenylate cyclase in Schizosaccharomyces pombe. Here, we studied the functional conservation between moc1/sds23 and its two orthologs SDS23 and SDS24 in Saccharomyces cerevisiae. We observed that the temperature sensitivity, salt tolerance, cell morphology, and sterility of the Deltamoc1 mutant in S. pombe were recovered by expressing either S. cerevisiae SDS23 or SDS24. We found that deletion of both SDS23 and SDS24 resulted in the production of a large vacuole that was reversed by the expression of S. pombe moc1/sds23. In these ways we found that S. pombe Moc1/Sds23 and S. cerevisiae SDS23p or SDS24p are functional homologs. In addition we found that the Deltasds23 Deltasds24 diploid strain reduces cell separation in forming pseudohyphal-like growth in S. cerevisiae. Thus S. pombe moc1/sds23 and S. cerevisiae SDS23 or SDS24 are interchangeable with each other, but their disruptants are phenotypically dissimilar." @default.
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- W2059441331 date "2005-01-01" @default.
- W2059441331 modified "2023-10-16" @default.
- W2059441331 title "Functional Conservation between Fission Yeast<i>moc1/sds23</i>and Its Two Orthologs, Budding Yeast<i>SDS23</i>and<i>SDS24</i>, and Phenotypic Differences in Their Disruptants" @default.
- W2059441331 cites W95643056 @default.
- W2059441331 doi "https://doi.org/10.1271/bbb.69.1422" @default.
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