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• W2059442246 abstract "In Brief Craniofacial distraction osteogenesis (DO) is an evolving reconstructive technique with expanding applications for the treatment of bony deficiencies of the facial skeleton. Mechanical force has been known to play a fundamental role in modulating sustained osteogenic response and therefore is believed to function as a critical regulator of DO. We hypothesize that key clustering components of an integrin-mediated signaling pathway, including c-Src (pp60src), are necessary for mediating the response to mechanical force. The specific aim of this study is to demonstrate up-regulation of a key focal adhesion molecule, c-Src, selectively in new bone formation subject to the mechanical forces of distraction and to demonstrate a lack of that same up-regulation in new bone formation associated with simple fracture healing. An additional specific aim is to demonstrate colocalization of c-Src expression and bone morphogenetic protein (BMP 2/4) expression during mandibular DO. Using a rat model of mandibular DO, c-Src and BMP 2/4 expression were evaluated in critical size defects, subcritical size defects, and mandibles undergoing gradual distraction. Osseous regeneration was observed in the course of gradual distraction; this process was associated with increased expression of c-Src. Furthermore, the presence of BMP 2/4 closely approximated c-Src expression spatially and temporally, suggesting a link between cytoplasmic focal adhesion activation and the resultant nuclear regulation of osteogenic protein expression. In significant contradistinction, minimal c-Src expression was found in the subcritical-sized defects where the fractures healed secondarily but where no gradual distraction was performed. Instead, the new bone formation inherent in the secondarily healed subcritical-sized defects demonstrated expected BMP 2/4 expression but was devoid of an up-regulation of c-Src. Finally, as expected, minimal expression of both c-Src and BMP was found in fibrous nonunion specimens. C-src expression was observed during gradual distraction; furthermore, minimal c-Src expression was visualized during subacute and critical-size defect fracture healing. C-Src expression also closely approximated BMP expression during DO. These findings that c-Src expression is found primarily only during conditions of cyclic distraction forces strongly implicates that mechanical force during gradual distraction is associated with c-Src expression. These results provide in vivo support for previous in vitro evidence that mechanical force profoundly influences osseous regeneration during distraction osteogenesis by means of a c-Src dependent mechanotransduction pathway, resulting in increased expression of osteogenic proteins, including BMP 2/4. In a rat model of mandibular distraction osteogenesis, parallel increased expression of c-Src and BMP 2/4 was found. However, when a subcritical-size bone gap was immediately created, BMP 2/4 was elevated but there was no corresponding upregulation of c-Src, confirming the importance of the latter as a mediator in responding to mechanical force." @default.
• W2059442246 created "2016-06-24" @default.
• W2059442246 creator A5036135458 @default.
• W2059442246 creator A5052000699 @default.
• W2059442246 date "2005-08-01" @default.
• W2059442246 modified "2023-09-25" @default.
• W2059442246 title "Colocalization of c-Src (pp60src) and Bone Morphogenetic Protein 2/4 Expression During Mandibular Distraction Osteogenesis" @default.
• W2059442246 cites W1537399302 @default.
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• W2059442246 cites W1811488600 @default.
• W2059442246 cites W1916156238 @default.
• W2059442246 cites W1936770188 @default.
• W2059442246 cites W1963712887 @default.
• W2059442246 cites W1963826848 @default.
• W2059442246 cites W1965397720 @default.
• W2059442246 cites W1968822620 @default.
• W2059442246 cites W1972811230 @default.
• W2059442246 cites W1975621622 @default.
• W2059442246 cites W1977161117 @default.
• W2059442246 cites W1984054737 @default.
• W2059442246 cites W1985199092 @default.
• W2059442246 cites W1989629699 @default.
• W2059442246 cites W1990854759 @default.
• W2059442246 cites W1991296630 @default.
• W2059442246 cites W1993985103 @default.
• W2059442246 cites W1994651714 @default.
• W2059442246 cites W1996574729 @default.
• W2059442246 cites W1999666161 @default.
• W2059442246 cites W2001696158 @default.
• W2059442246 cites W2002820110 @default.
• W2059442246 cites W2007349364 @default.
• W2059442246 cites W2007421109 @default.
• W2059442246 cites W2011016249 @default.
• W2059442246 cites W2011407036 @default.
• W2059442246 cites W2012620978 @default.
• W2059442246 cites W2021228022 @default.
• W2059442246 cites W2027790303 @default.
• W2059442246 cites W2028901102 @default.
• W2059442246 cites W2029287842 @default.
• W2059442246 cites W2036734848 @default.
• W2059442246 cites W2039698335 @default.
• W2059442246 cites W2055171998 @default.
• W2059442246 cites W2060276230 @default.
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• W2059442246 cites W2061921618 @default.
• W2059442246 cites W2064115554 @default.
• W2059442246 cites W2066367871 @default.
• W2059442246 cites W2068948015 @default.
• W2059442246 cites W2071316138 @default.
• W2059442246 cites W2084162464 @default.
• W2059442246 cites W2087122586 @default.
• W2059442246 cites W2089386382 @default.
• W2059442246 cites W2093509637 @default.
• W2059442246 cites W2094173028 @default.
• W2059442246 cites W2102143438 @default.
• W2059442246 cites W2103164354 @default.
• W2059442246 cites W2110785919 @default.
• W2059442246 cites W2112093320 @default.
• W2059442246 cites W2113396371 @default.
• W2059442246 cites W2114471467 @default.
• W2059442246 cites W2116045343 @default.
• W2059442246 cites W2126087366 @default.
• W2059442246 cites W2128967156 @default.
• W2059442246 cites W2130952789 @default.
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• W2059442246 cites W2138852525 @default.
• W2059442246 cites W2160022719 @default.
• W2059442246 cites W2162297869 @default.
• W2059442246 cites W2179004761 @default.
• W2059442246 cites W4230761729 @default.
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• W2059442246 doi "https://doi.org/10.1097/01.sap.0000164576.10754.aa" @default.
• W2059442246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16034255" @default.
• W2059442246 hasPublicationYear "2005" @default.
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