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- W2059442796 abstract "Obscurin (800-900 kDa) is a giant muscle protein vital to muscle cell maintenance and organization. It is the only known connection between the contractile apparatus and the sarcoplasmic reticulum and also binds to specific cytoskeletal, signaling, or membrane-associated proteins. Obscurin domains Ig58/59 bind to titin ZIg9/10, which is hypothesized to stabilize the sarcomeric cytoskeleton. Mutations in this obscurin region lead to malformed muscle architecture and, eventually, to hypertrophic cardiomyopathy (HCM). For obscurin/titin binding to occur, all four of these domains must be present. In order to fully characterize this physiologically important region of obscurin, and by extension determine the molecular factors that drive HCM, here we present the Ig58 and Ig59 structure using both X-ray crystallography and heteronuclear multidimensional NMR spectra. Low-resolution structure and dynamics of these tandem domains, along with how these domains react to physical stress, are also discussed." @default.
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- W2059442796 date "2015-01-01" @default.
- W2059442796 modified "2023-09-29" @default.
- W2059442796 title "Structure and Molecular Dynamics of the Ig58/58 Domains of Obscurin" @default.
- W2059442796 doi "https://doi.org/10.1016/j.bpj.2014.11.2795" @default.
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