Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059442912> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2059442912 endingPage "702" @default.
- W2059442912 startingPage "699" @default.
- W2059442912 abstract "Human hair growth can be monitored for several months after the transplantation of scalp samples from men with androgen‐dependent alopecia on to female nude mice. Hair production from balding sites has been shown to be inhibited in testosterone‐conditioned nude mice. We used this recently reported model to study the effect of a new non‐steroidal antiandrogen – RU 58841 – on human hair growth. Twenty productive scalp grafts from balding men were maintained for 8 months after grafting on to nude mice, and hair production was monitored monthly for 6 months. All mice were conditioned by the topical application of testosterone (testosterone propionate. 300 μg in 10μL; 5 days/week) on the non‐grafted flank. The scalp samples were divided equally according to the estimated hair production potential, which was based on the amount of hair present on the scalp samples before grafting. Each of the two equal groups of grafts was further allocated at random to be treated topically (5 days/week) with blinded solutions of either RU 58841 1% in ethanol, or ethanol as a control. Twenty‐eight active follicles appeared on the 10 control grafts. Among them only two follicles (7%) initiated a second hair cycle. However, the 10 RU58841‐treated grafts bore a total of 29 active follicles, and eight of them (28%) showed a second cycle. The values for the linear hair growth rates (LHGR) were significantly (P<0.04) higher in the RU58841‐treated group. Recycling and increased LHGR indicate a positive action for RU58841 on human hair growth from balding samples grafted on to testosterone‐conditioned nude mice, and encourage a clinical trial to evaluate its potential in the treatment of androgen‐dependent alopecia." @default.
- W2059442912 created "2016-06-24" @default.
- W2059442912 creator A5029414924 @default.
- W2059442912 creator A5034459287 @default.
- W2059442912 creator A5036991725 @default.
- W2059442912 creator A5075055200 @default.
- W2059442912 creator A5081319038 @default.
- W2059442912 date "1997-11-01" @default.
- W2059442912 modified "2023-09-27" @default.
- W2059442912 title "A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice" @default.
- W2059442912 cites W1965461549 @default.
- W2059442912 cites W1982264390 @default.
- W2059442912 cites W1986777660 @default.
- W2059442912 cites W1997695802 @default.
- W2059442912 cites W2001110023 @default.
- W2059442912 cites W2071745837 @default.
- W2059442912 cites W2072876637 @default.
- W2059442912 cites W2089096580 @default.
- W2059442912 cites W2109597834 @default.
- W2059442912 doi "https://doi.org/10.1046/j.1365-2133.1997.19382053.x" @default.
- W2059442912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9415227" @default.
- W2059442912 hasPublicationYear "1997" @default.
- W2059442912 type Work @default.
- W2059442912 sameAs 2059442912 @default.
- W2059442912 citedByCount "10" @default.
- W2059442912 countsByYear W20594429122014 @default.
- W2059442912 countsByYear W20594429122016 @default.
- W2059442912 countsByYear W20594429122021 @default.
- W2059442912 crossrefType "journal-article" @default.
- W2059442912 hasAuthorship W2059442912A5029414924 @default.
- W2059442912 hasAuthorship W2059442912A5034459287 @default.
- W2059442912 hasAuthorship W2059442912A5036991725 @default.
- W2059442912 hasAuthorship W2059442912A5075055200 @default.
- W2059442912 hasAuthorship W2059442912A5081319038 @default.
- W2059442912 hasConcept C126322002 @default.
- W2059442912 hasConcept C134018914 @default.
- W2059442912 hasConcept C141071460 @default.
- W2059442912 hasConcept C16005928 @default.
- W2059442912 hasConcept C2776360568 @default.
- W2059442912 hasConcept C2777786686 @default.
- W2059442912 hasConcept C2777911890 @default.
- W2059442912 hasConcept C2778515351 @default.
- W2059442912 hasConcept C2779279991 @default.
- W2059442912 hasConcept C2779322244 @default.
- W2059442912 hasConcept C2781115071 @default.
- W2059442912 hasConcept C2908979026 @default.
- W2059442912 hasConcept C3020618081 @default.
- W2059442912 hasConcept C42407357 @default.
- W2059442912 hasConcept C71315377 @default.
- W2059442912 hasConcept C71924100 @default.
- W2059442912 hasConcept C86803240 @default.
- W2059442912 hasConceptScore W2059442912C126322002 @default.
- W2059442912 hasConceptScore W2059442912C134018914 @default.
- W2059442912 hasConceptScore W2059442912C141071460 @default.
- W2059442912 hasConceptScore W2059442912C16005928 @default.
- W2059442912 hasConceptScore W2059442912C2776360568 @default.
- W2059442912 hasConceptScore W2059442912C2777786686 @default.
- W2059442912 hasConceptScore W2059442912C2777911890 @default.
- W2059442912 hasConceptScore W2059442912C2778515351 @default.
- W2059442912 hasConceptScore W2059442912C2779279991 @default.
- W2059442912 hasConceptScore W2059442912C2779322244 @default.
- W2059442912 hasConceptScore W2059442912C2781115071 @default.
- W2059442912 hasConceptScore W2059442912C2908979026 @default.
- W2059442912 hasConceptScore W2059442912C3020618081 @default.
- W2059442912 hasConceptScore W2059442912C42407357 @default.
- W2059442912 hasConceptScore W2059442912C71315377 @default.
- W2059442912 hasConceptScore W2059442912C71924100 @default.
- W2059442912 hasConceptScore W2059442912C86803240 @default.
- W2059442912 hasIssue "5" @default.
- W2059442912 hasLocation W20594429121 @default.
- W2059442912 hasLocation W20594429122 @default.
- W2059442912 hasOpenAccess W2059442912 @default.
- W2059442912 hasPrimaryLocation W20594429121 @default.
- W2059442912 hasRelatedWork W1977970588 @default.
- W2059442912 hasRelatedWork W1981433740 @default.
- W2059442912 hasRelatedWork W2001381637 @default.
- W2059442912 hasRelatedWork W2022659954 @default.
- W2059442912 hasRelatedWork W2059433953 @default.
- W2059442912 hasRelatedWork W2059442912 @default.
- W2059442912 hasRelatedWork W2076782687 @default.
- W2059442912 hasRelatedWork W2101146068 @default.
- W2059442912 hasRelatedWork W2104661501 @default.
- W2059442912 hasRelatedWork W3000732871 @default.
- W2059442912 hasVolume "137" @default.
- W2059442912 isParatext "false" @default.
- W2059442912 isRetracted "false" @default.
- W2059442912 magId "2059442912" @default.
- W2059442912 workType "article" @default.