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- W2059443132 abstract "Spontaneous activity fine-tunes neuronal connections in the developing brain. To explore the underlying synaptic plasticity mechanisms, we monitored naturally occurring changes in spontaneous activity at individual synapses with whole-cell patch-clamp recordings and simultaneous calcium imaging in the mouse visual cortex in vivo. Analyzing activity changes across large populations of synapses revealed a simple and efficient local plasticity rule: synapses that exhibit low synchronicity with nearby neighbors (<12 μm) become depressed in their transmission frequency. Asynchronous electrical stimulation of individual synapses in hippocampal slices showed that this is due to a decrease in synaptic transmission efficiency. Accordingly, experimentally increasing local synchronicity, by stimulating synapses in response to spontaneous activity at neighboring synapses, stabilized synaptic transmission. Finally, blockade of the high-affinity proBDNF receptor p75NTR prevented the depression of asynchronously stimulated synapses. Thus, spontaneous activity drives local synaptic plasticity at individual synapses in an “out-of-sync, lose-your-link” fashion through proBDNF/p75NTR signaling to refine neuronal connectivity." @default.
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- W2059443132 date "2008-08-01" @default.
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- W2059443132 title "P.3.a.017 Decreased serum pro BDNF/BDNF ratio in patients with schizophrenia" @default.
- W2059443132 doi "https://doi.org/10.1016/s0924-977x(08)70570-4" @default.
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