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- W2059445529 abstract "To determine whether prolonged activation of a phospholipase C-coupled receptor can lead to a down-regulation of its effector enzyme, SH-SY5Y neuroblastoma cells were incubated for 24 h with the muscarinic receptor agonist, oxotremorine-M. Under these conditions, significant reductions (46-53%) in muscarinic cholinergic receptor density, G(alphaq/11) and phospholipase C-beta1 (but not the beta3-or gamma1 isoforms) were observed. These results suggest that a selective down-regulation of phospholipase C-beta1 may play a role in adaptation to chronic muscarinic receptor activation." @default.
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- W2059445529 date "1998-04-01" @default.
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- W2059445529 title "Down-regulation of phospholipase C-β1 following chronic muscarinic receptor activation" @default.
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- W2059445529 doi "https://doi.org/10.1016/s0014-2999(98)00125-3" @default.
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