FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059446720> ?p ?o ?g. }

• W2059446720 endingPage "191" @default.
• W2059446720 startingPage "183" @default.
• W2059446720 abstract "Cancers can escape immune recognition by means of evading class I major histocompatibility complex (MHC) -mediated recognition by cytotoxic T lymphocytes. However, immunization strategies targeting defined tumor-associated antigens have not been extensively characterized in murine prostate cancer models. Therefore, we evaluated antigen-specific, antitumor immunity after antigen-encoding vaccinia immunization against mouse prostate cancer cells expressing a model tumor-associated antigen (beta-galactosidase) and exhibiting partially deficient class I MHC.Low class I MHC expression in beta-galactosidase-expressing D7RM-1 prostate cancer cells was shown by fluorescence activated cell sorting, and deficient class I MHC-mediated antigen presentation was shown in resistance of D7RM-1 to cytolysis by beta-galactosidase-specific cytotoxic T lymphocytes (CTL). Despite partially deficient class I MHC presenting function, immunization with vaccinia encoding beta-galactosidase conferred antigen-specific protection against D7RM-1 cancer. Antigen-specific immunity was recapitulated in beta(2)m knockout mice (with deficient class I MHC and CTL function), confirming that class I MHC antigen presentation was not required for immunity against tumor partially deficient in class I MHC. Conversely, antigen-specific antitumor immunity was abrogated in A(b)beta knockout mice (with deficient class II MHC and helper T cell function), demonstrating a requirement for functional class II MHC. Resistant tumors from the otherwise effectively immunized beta(2)m knockout mice (among which tumor progression had been reduced or delayed) showed reduced target antigen expression, corroborating antigen-specificity (and showing an alternative immune escape mechanism), whereas antigen expression (like tumor growth) was unaffected among A(b)beta knockout mice.Our results demonstrate that class I MHC-restricted antigen presentation and CTL activity is neither necessary nor sufficient for antigen-encoding vaccinia immunization to induce protective immunity against class I MHC-low tumors, whereas host class II MHC-mediated antigen presentation facilitates antigen-specific immunity against prostate cancer in vivo. Reduced expression of the target antigen developed rapidly in vivo as an immune escape mechanism for such cancers." @default.
• W2059446720 created "2016-06-24" @default.
• W2059446720 creator A5004417664 @default.
• W2059446720 creator A5038740158 @default.
• W2059446720 creator A5044032746 @default.
• W2059446720 creator A5061987607 @default.
• W2059446720 creator A5083188016 @default.
• W2059446720 date "2002-10-17" @default.
• W2059446720 modified "2023-10-16" @default.
• W2059446720 title "Antigen-specific tumor vaccine efficacy in vivo against prostate cancer with low class I MHC requires competent class II MHC" @default.
• W2059446720 cites W1494836084 @default.
• W2059446720 cites W1556149314 @default.
• W2059446720 cites W1669573844 @default.
• W2059446720 cites W1929389993 @default.
• W2059446720 cites W1962674786 @default.
• W2059446720 cites W1992700503 @default.
• W2059446720 cites W2005189185 @default.
• W2059446720 cites W2019653601 @default.
• W2059446720 cites W2042052546 @default.
• W2059446720 cites W2042946852 @default.
• W2059446720 cites W2050474055 @default.
• W2059446720 cites W2052363929 @default.
• W2059446720 cites W2054646159 @default.
• W2059446720 cites W2055316648 @default.
• W2059446720 cites W2062122915 @default.
• W2059446720 cites W2063366670 @default.
• W2059446720 cites W2064523871 @default.
• W2059446720 cites W2080537082 @default.
• W2059446720 cites W2086770363 @default.
• W2059446720 cites W2092876476 @default.
• W2059446720 cites W2093143038 @default.
• W2059446720 cites W2116236834 @default.
• W2059446720 cites W2125163888 @default.
• W2059446720 cites W2125552337 @default.
• W2059446720 cites W2139761942 @default.
• W2059446720 cites W2140413450 @default.
• W2059446720 cites W2149366474 @default.
• W2059446720 cites W2149586260 @default.
• W2059446720 cites W2149627334 @default.
• W2059446720 cites W2155778479 @default.
• W2059446720 cites W2247920240 @default.
• W2059446720 cites W2474076236 @default.
• W2059446720 doi "https://doi.org/10.1002/pros.10136" @default.
• W2059446720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2042541" @default.
• W2059446720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12386918" @default.
• W2059446720 hasPublicationYear "2002" @default.
• W2059446720 type Work @default.
• W2059446720 sameAs 2059446720 @default.
• W2059446720 citedByCount "10" @default.
• W2059446720 countsByYear W20594467202012 @default.
• W2059446720 countsByYear W20594467202014 @default.
• W2059446720 countsByYear W20594467202015 @default.
• W2059446720 countsByYear W20594467202020 @default.
• W2059446720 countsByYear W20594467202022 @default.
• W2059446720 crossrefType "journal-article" @default.
• W2059446720 hasAuthorship W2059446720A5004417664 @default.
• W2059446720 hasAuthorship W2059446720A5038740158 @default.
• W2059446720 hasAuthorship W2059446720A5044032746 @default.
• W2059446720 hasAuthorship W2059446720A5061987607 @default.
• W2059446720 hasAuthorship W2059446720A5083188016 @default.
• W2059446720 hasBestOaLocation W20594467202 @default.
• W2059446720 hasConcept C108249834 @default.
• W2059446720 hasConcept C147483822 @default.
• W2059446720 hasConcept C147969180 @default.
• W2059446720 hasConcept C154317977 @default.
• W2059446720 hasConcept C167672396 @default.
• W2059446720 hasConcept C170627219 @default.
• W2059446720 hasConcept C202751555 @default.
• W2059446720 hasConcept C203014093 @default.
• W2059446720 hasConcept C207936829 @default.
• W2059446720 hasConcept C2776662205 @default.
• W2059446720 hasConcept C2777701055 @default.
• W2059446720 hasConcept C2778814158 @default.
• W2059446720 hasConcept C502942594 @default.
• W2059446720 hasConcept C54355233 @default.
• W2059446720 hasConcept C86803240 @default.
• W2059446720 hasConcept C8891405 @default.
• W2059446720 hasConceptScore W2059446720C108249834 @default.
• W2059446720 hasConceptScore W2059446720C147483822 @default.
• W2059446720 hasConceptScore W2059446720C147969180 @default.
• W2059446720 hasConceptScore W2059446720C154317977 @default.
• W2059446720 hasConceptScore W2059446720C167672396 @default.
• W2059446720 hasConceptScore W2059446720C170627219 @default.
• W2059446720 hasConceptScore W2059446720C202751555 @default.
• W2059446720 hasConceptScore W2059446720C203014093 @default.
• W2059446720 hasConceptScore W2059446720C207936829 @default.
• W2059446720 hasConceptScore W2059446720C2776662205 @default.
• W2059446720 hasConceptScore W2059446720C2777701055 @default.
• W2059446720 hasConceptScore W2059446720C2778814158 @default.
• W2059446720 hasConceptScore W2059446720C502942594 @default.
• W2059446720 hasConceptScore W2059446720C54355233 @default.
• W2059446720 hasConceptScore W2059446720C86803240 @default.
• W2059446720 hasConceptScore W2059446720C8891405 @default.
• W2059446720 hasIssue "3" @default.
• W2059446720 hasLocation W20594467201 @default.
• W2059446720 hasLocation W20594467202 @default.
• W2059446720 hasLocation W20594467203 @default.
• W2059446720 hasLocation W20594467204 @default.

• next