FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059453497> ?p ?o ?g. }

• W2059453497 endingPage "158" @default.
• W2059453497 startingPage "152" @default.
• W2059453497 abstract "Nitric oxide signaling pathways are of central importance in both the maintenance of vascular homeostasis and the progression of vascular disease. Since smooth muscle cell apoptosis is associated with numerous vascular disorders, the authors investigated whether YC-1, a soluble guanylyl cyclase (sGC) activator, regulates apoptosis in vascular smooth muscle cells (VSMC).Sodium nitroprusside (SNP) (1 mM) induced cGMP (guanosine 3':5'-cyclic monophosphate)-independent apoptosis in rat vascular smooth muscle cells using MTT assay and TUNEL-reaction techniques. Furthermore, sodium nitroprusside induced apoptosis via Bcl-2 down-regulation, cytochrome c release reaction, and caspase-3 activation by Western blotting analysis and enzymatic assay methods. YC-1 abolished these apoptotic signaling cascades and prevented apoptosis through a cGMP-involved pathway, and phosphatidylinositol (PI) 3-kinase behaved a downstream event in this pathway.These results suggest that YC-1 inhibits sodium nitroprusside-induced vascular smooth muscle cells apoptosis via a cGMP- and phosphatidylinositol 3-kinase-involved inhibition on Bcl-2 down-regulation/cytochrome c release/caspase-3 activation cascades. The ability of YC-1 to prevent smooth muscle cell apoptosis may play an important role in blocking lesion formation at sites of vascular injury." @default.
• W2059453497 created "2016-06-24" @default.
• W2059453497 creator A5016825023 @default.
• W2059453497 creator A5024679323 @default.
• W2059453497 creator A5049312136 @default.
• W2059453497 creator A5057812012 @default.
• W2059453497 creator A5071674467 @default.
• W2059453497 creator A5075967549 @default.
• W2059453497 date "2004-01-01" @default.
• W2059453497 modified "2023-10-13" @default.
• W2059453497 title "YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells" @default.
• W2059453497 cites W1483751226 @default.
• W2059453497 cites W186823696 @default.
• W2059453497 cites W1974980101 @default.
• W2059453497 cites W1978315067 @default.
• W2059453497 cites W1990798856 @default.
• W2059453497 cites W1998033241 @default.
• W2059453497 cites W2001656598 @default.
• W2059453497 cites W2002370407 @default.
• W2059453497 cites W2005515164 @default.
• W2059453497 cites W2022456041 @default.
• W2059453497 cites W2025816795 @default.
• W2059453497 cites W2033063036 @default.
• W2059453497 cites W2034946903 @default.
• W2059453497 cites W2041075406 @default.
• W2059453497 cites W2048121649 @default.
• W2059453497 cites W2049100449 @default.
• W2059453497 cites W2061341532 @default.
• W2059453497 cites W2069881405 @default.
• W2059453497 cites W2070732456 @default.
• W2059453497 cites W2088968342 @default.
• W2059453497 cites W2098770709 @default.
• W2059453497 cites W2118440238 @default.
• W2059453497 cites W2131280359 @default.
• W2059453497 cites W2134675216 @default.
• W2059453497 cites W2148908421 @default.
• W2059453497 cites W2168257088 @default.
• W2059453497 cites W2313518958 @default.
• W2059453497 cites W2467657054 @default.
• W2059453497 cites W2471109010 @default.
• W2059453497 doi "https://doi.org/10.1016/j.cardiores.2003.09.013" @default.
• W2059453497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14732212" @default.
• W2059453497 hasPublicationYear "2004" @default.
• W2059453497 type Work @default.
• W2059453497 sameAs 2059453497 @default.
• W2059453497 citedByCount "35" @default.
• W2059453497 countsByYear W20594534972012 @default.
• W2059453497 countsByYear W20594534972013 @default.
• W2059453497 countsByYear W20594534972016 @default.
• W2059453497 countsByYear W20594534972017 @default.
• W2059453497 crossrefType "journal-article" @default.
• W2059453497 hasAuthorship W2059453497A5016825023 @default.
• W2059453497 hasAuthorship W2059453497A5024679323 @default.
• W2059453497 hasAuthorship W2059453497A5049312136 @default.
• W2059453497 hasAuthorship W2059453497A5057812012 @default.
• W2059453497 hasAuthorship W2059453497A5071674467 @default.
• W2059453497 hasAuthorship W2059453497A5075967549 @default.
• W2059453497 hasBestOaLocation W20594534971 @default.
• W2059453497 hasConcept C134018914 @default.
• W2059453497 hasConcept C173803235 @default.
• W2059453497 hasConcept C185592680 @default.
• W2059453497 hasConcept C190283241 @default.
• W2059453497 hasConcept C195794163 @default.
• W2059453497 hasConcept C196795494 @default.
• W2059453497 hasConcept C199217515 @default.
• W2059453497 hasConcept C2778827303 @default.
• W2059453497 hasConcept C2779395532 @default.
• W2059453497 hasConcept C2779610285 @default.
• W2059453497 hasConcept C2780994212 @default.
• W2059453497 hasConcept C29311851 @default.
• W2059453497 hasConcept C2992686903 @default.
• W2059453497 hasConcept C519581460 @default.
• W2059453497 hasConcept C55493867 @default.
• W2059453497 hasConcept C62478195 @default.
• W2059453497 hasConcept C86803240 @default.
• W2059453497 hasConcept C90934575 @default.
• W2059453497 hasConcept C95444343 @default.
• W2059453497 hasConceptScore W2059453497C134018914 @default.
• W2059453497 hasConceptScore W2059453497C173803235 @default.
• W2059453497 hasConceptScore W2059453497C185592680 @default.
• W2059453497 hasConceptScore W2059453497C190283241 @default.
• W2059453497 hasConceptScore W2059453497C195794163 @default.
• W2059453497 hasConceptScore W2059453497C196795494 @default.
• W2059453497 hasConceptScore W2059453497C199217515 @default.
• W2059453497 hasConceptScore W2059453497C2778827303 @default.
• W2059453497 hasConceptScore W2059453497C2779395532 @default.
• W2059453497 hasConceptScore W2059453497C2779610285 @default.
• W2059453497 hasConceptScore W2059453497C2780994212 @default.
• W2059453497 hasConceptScore W2059453497C29311851 @default.
• W2059453497 hasConceptScore W2059453497C2992686903 @default.
• W2059453497 hasConceptScore W2059453497C519581460 @default.
• W2059453497 hasConceptScore W2059453497C55493867 @default.
• W2059453497 hasConceptScore W2059453497C62478195 @default.
• W2059453497 hasConceptScore W2059453497C86803240 @default.
• W2059453497 hasConceptScore W2059453497C90934575 @default.
• W2059453497 hasConceptScore W2059453497C95444343 @default.
• W2059453497 hasIssue "1" @default.
• W2059453497 hasLocation W20594534971 @default.

• next