FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059458450> ?p ?o ?g. }

• W2059458450 endingPage "625" @default.
• W2059458450 startingPage "611" @default.
• W2059458450 abstract "Elucidating the temporal natural history of Hepatitis B virus (HBV) infection provides not only useful information for assessing the spread of HBV infection but also a bedrock for economic appraisal of population-based preventive strategies (such as universal vaccination). HBV transmissions are transmitted through the maternal (vertical) route and environmental (horizontal) route. As the infection process from susceptible to active virus replication and finally to recovery state or to carrier state through both routes is not directly observable, mathematical models were therefore proposed to quantitatively elucidate the dynamic process of HBV infection with time. We began with a simple two-state model (from susceptible to infection) and further developed a five-state (including susceptible, latent phase, active viral replication, carrier, and recovery states) stochastic process to quantify the dynamics of HBV infection, making allowances for a mixed proportion of vertical and horizontal transmissions. The data used in the estimation, which were collected before implementation of a policy for universal HBV vaccination, were derived from several previous serum prevalence studies, including both low (northern) and high (southern) HBV prevalence areas, in Taiwan. The parameters obtained from stochastic models were converted to compute the basic reproductive number (R0) in each study to indicate the extent of the spread of HBV infection. By linking the temporal natural history of HBV infection with the previously established Markov process for the sequelae of HBV infection (chronic hepatitis infection, liver cirrhosis, and hepatocelluar carcinoma), we developed a Markov cycle decision tree to evaluate the two population-based preventive strategies related to vaccination and maternal lamivudine use with a cost-effectiveness analysis. In the five-state model, horizontal transmission was found to contribute more to HBV infection than vertical transmission in the northern area (59 vs. 41 %), whereas vertical transmission was more likely than horizontal transmission in the southern area (80 vs. 20 %). After considering the parameters of the two transmission routes, annual infection rate (person-years) for susceptible subjects was higher in the northern area (0.35) than the southern area (0.011). A similar finding was noted for annual rate of the transition from the latent period to active viral replications (1.12 in the northern area and 0.072 in the southern area). Annual rate of the conversion from active viral replication to the carrier state was higher in the southern area (0.184) than the northern area (0.119). Annual recovery rates were 0.014 in the northern area and 0.024 in the southern area for the carrier and 0.048 and 0.088 for transient viremia. The R0 at age 30 using the parameters obtained from the five-state stochastic model was estimated as 4.88 in the northern and 7.03 in the southern area. Regarding the findings of economic appraisal, both preventive strategies were cost-saving, yielding the negative value of incremental cost-effectiveness ratio, compared with the baseline group (no intervention), regardless of areas. The preventive strategies in the southern area were more cost-saving than those in the northern area. The consolidation of elucidating the temporal natural history of HBV infection, estimating basic reproductive number, and conducting an economic appraisal of population-based preventive strategy can aid health policy-makers in designing effective preventive strategies in other countries worldwide where HBV is still prevalent. However, the empirical findings on transmission routes and the temporal evolution of HBV infection varying with areas should be considered with great caution as only two studies were modeled." @default.
• W2059458450 created "2016-06-24" @default.
• W2059458450 creator A5000703340 @default.
• W2059458450 creator A5004991192 @default.
• W2059458450 creator A5035627161 @default.
• W2059458450 creator A5067193559 @default.
• W2059458450 date "2013-08-17" @default.
• W2059458450 modified "2023-09-30" @default.
• W2059458450 title "Stochastic model for hepatitis B virus infection through maternal (vertical) and environmental (horizontal) transmission with applications to basic reproductive number estimation and economic appraisal of preventive strategies" @default.
• W2059458450 cites W1575785667 @default.
• W2059458450 cites W1903855464 @default.
• W2059458450 cites W1953651259 @default.
• W2059458450 cites W1967693127 @default.
• W2059458450 cites W1983697149 @default.
• W2059458450 cites W1989469927 @default.
• W2059458450 cites W1991728592 @default.
• W2059458450 cites W1996230070 @default.
• W2059458450 cites W2002740941 @default.
• W2059458450 cites W2004506270 @default.
• W2059458450 cites W2007417405 @default.
• W2059458450 cites W2011592321 @default.
• W2059458450 cites W2071966334 @default.
• W2059458450 cites W2074197155 @default.
• W2059458450 cites W2084722886 @default.
• W2059458450 cites W2091304371 @default.
• W2059458450 cites W2091412291 @default.
• W2059458450 cites W2099659744 @default.
• W2059458450 cites W2116723799 @default.
• W2059458450 cites W2142143280 @default.
• W2059458450 cites W2154841493 @default.
• W2059458450 cites W2161962640 @default.
• W2059458450 cites W2162903981 @default.
• W2059458450 cites W2164806154 @default.
• W2059458450 cites W2167744756 @default.
• W2059458450 cites W2279871407 @default.
• W2059458450 cites W2283886095 @default.
• W2059458450 doi "https://doi.org/10.1007/s00477-013-0776-0" @default.
• W2059458450 hasPublicationYear "2013" @default.
• W2059458450 type Work @default.
• W2059458450 sameAs 2059458450 @default.
• W2059458450 citedByCount "8" @default.
• W2059458450 countsByYear W20594584502016 @default.
• W2059458450 countsByYear W20594584502017 @default.
• W2059458450 countsByYear W20594584502018 @default.
• W2059458450 countsByYear W20594584502023 @default.
• W2059458450 crossrefType "journal-article" @default.
• W2059458450 hasAuthorship W2059458450A5000703340 @default.
• W2059458450 hasAuthorship W2059458450A5004991192 @default.
• W2059458450 hasAuthorship W2059458450A5035627161 @default.
• W2059458450 hasAuthorship W2059458450A5067193559 @default.
• W2059458450 hasBestOaLocation W20594584501 @default.
• W2059458450 hasConcept C159047783 @default.
• W2059458450 hasConcept C204264503 @default.
• W2059458450 hasConcept C22070199 @default.
• W2059458450 hasConcept C2522874641 @default.
• W2059458450 hasConcept C2777382497 @default.
• W2059458450 hasConcept C2780263730 @default.
• W2059458450 hasConcept C2780593183 @default.
• W2059458450 hasConcept C2908647359 @default.
• W2059458450 hasConcept C41008148 @default.
• W2059458450 hasConcept C71924100 @default.
• W2059458450 hasConcept C761482 @default.
• W2059458450 hasConcept C76155785 @default.
• W2059458450 hasConcept C99454951 @default.
• W2059458450 hasConceptScore W2059458450C159047783 @default.
• W2059458450 hasConceptScore W2059458450C204264503 @default.
• W2059458450 hasConceptScore W2059458450C22070199 @default.
• W2059458450 hasConceptScore W2059458450C2522874641 @default.
• W2059458450 hasConceptScore W2059458450C2777382497 @default.
• W2059458450 hasConceptScore W2059458450C2780263730 @default.
• W2059458450 hasConceptScore W2059458450C2780593183 @default.
• W2059458450 hasConceptScore W2059458450C2908647359 @default.
• W2059458450 hasConceptScore W2059458450C41008148 @default.
• W2059458450 hasConceptScore W2059458450C71924100 @default.
• W2059458450 hasConceptScore W2059458450C761482 @default.
• W2059458450 hasConceptScore W2059458450C76155785 @default.
• W2059458450 hasConceptScore W2059458450C99454951 @default.
• W2059458450 hasIssue "3" @default.
• W2059458450 hasLocation W20594584501 @default.
• W2059458450 hasOpenAccess W2059458450 @default.
• W2059458450 hasPrimaryLocation W20594584501 @default.
• W2059458450 hasRelatedWork W2002712376 @default.
• W2059458450 hasRelatedWork W2010541536 @default.
• W2059458450 hasRelatedWork W2057974065 @default.
• W2059458450 hasRelatedWork W2098654902 @default.
• W2059458450 hasRelatedWork W2155739535 @default.
• W2059458450 hasRelatedWork W2270310143 @default.
• W2059458450 hasRelatedWork W2351679657 @default.
• W2059458450 hasRelatedWork W3194955546 @default.
• W2059458450 hasRelatedWork W4318914477 @default.
• W2059458450 hasRelatedWork W4383059263 @default.
• W2059458450 hasVolume "28" @default.
• W2059458450 isParatext "false" @default.
• W2059458450 isRetracted "false" @default.
• W2059458450 magId "2059458450" @default.
• W2059458450 workType "article" @default.