FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059462011> ?p ?o ?g. }

• W2059462011 endingPage "123" @default.
• W2059462011 startingPage "116" @default.
• W2059462011 abstract "Although head and neck cancer is not one of the most common cancers, it is a debilitating disease with poor prognosis and considerable post-treatment normal tissue toxicity. The unremitting search to increase the therapeutic ratio between tumour control and late normal tissue injury led to the adoption of altered fractionation schedules. While the increase in acute toxicity can be managed with appropriate medical support, damage produced to late responding tissues is usually irreversible, therefore clinically unacceptable. By altering the conventionally fractionated radiotherapy both loco-regional control and overall survival are increased. Moreover, phase III randomized trials indicated that the combined administration of cisplatin and radiotherapy further improves treatment outcome. Although the uptake of cisplatin in normal cells is not amplified by the combined modality treatment, cisplatin, by itself is a highly cytotoxic agent. Therefore, the need for normal tissue protection has arisen. Amifostine is a selective, radio-protective drug used in both radiotherapy and chemotherapy to reduce normal tissue toxicity. This paper provides an overview of clinical trials employing cisplatin-radiotherapy treatment for advanced head and neck cancer with specific focus on normal tissue toxicity. The emerging role of radioprotectors and furthermore, the effectiveness of amifostine in combined cisplatin-radiotherapy trials are presented." @default.
• W2059462011 created "2016-06-24" @default.
• W2059462011 creator A5009380500 @default.
• W2059462011 date "2009-03-01" @default.
• W2059462011 modified "2023-09-23" @default.
• W2059462011 title "The role of amifostine in the treatment of head and neck cancer with cisplatin-radiotherapy" @default.
• W2059462011 cites W1784479792 @default.
• W2059462011 cites W1966346228 @default.
• W2059462011 cites W1966675362 @default.
• W2059462011 cites W1980365752 @default.
• W2059462011 cites W1990582908 @default.
• W2059462011 cites W1993384565 @default.
• W2059462011 cites W1996594688 @default.
• W2059462011 cites W1998939814 @default.
• W2059462011 cites W2016709110 @default.
• W2059462011 cites W2022101062 @default.
• W2059462011 cites W2030475281 @default.
• W2059462011 cites W2036575905 @default.
• W2059462011 cites W2046159958 @default.
• W2059462011 cites W2049589006 @default.
• W2059462011 cites W2056549760 @default.
• W2059462011 cites W2061393333 @default.
• W2059462011 cites W2066334626 @default.
• W2059462011 cites W2071239103 @default.
• W2059462011 cites W2077921970 @default.
• W2059462011 cites W2079122999 @default.
• W2059462011 cites W2080170490 @default.
• W2059462011 cites W2082564384 @default.
• W2059462011 cites W2089607030 @default.
• W2059462011 cites W2093023735 @default.
• W2059462011 cites W2106694155 @default.
• W2059462011 cites W2111651157 @default.
• W2059462011 cites W2112207507 @default.
• W2059462011 cites W2116693921 @default.
• W2059462011 cites W2118708119 @default.
• W2059462011 cites W2124650760 @default.
• W2059462011 cites W2127963298 @default.
• W2059462011 cites W2145943661 @default.
• W2059462011 cites W2150665408 @default.
• W2059462011 cites W2151415400 @default.
• W2059462011 cites W2155822213 @default.
• W2059462011 cites W2157885764 @default.
• W2059462011 cites W2157904963 @default.
• W2059462011 cites W2164157162 @default.
• W2059462011 cites W2166267558 @default.
• W2059462011 cites W2182204746 @default.
• W2059462011 cites W2317301599 @default.
• W2059462011 cites W2402080091 @default.
• W2059462011 cites W4230563314 @default.
• W2059462011 doi "https://doi.org/10.1111/j.1365-2354.2008.01032.x" @default.
• W2059462011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19267726" @default.
• W2059462011 hasPublicationYear "2009" @default.
• W2059462011 type Work @default.
• W2059462011 sameAs 2059462011 @default.
• W2059462011 citedByCount "13" @default.
• W2059462011 countsByYear W20594620112012 @default.
• W2059462011 countsByYear W20594620112013 @default.
• W2059462011 countsByYear W20594620112016 @default.
• W2059462011 countsByYear W20594620112017 @default.
• W2059462011 crossrefType "journal-article" @default.
• W2059462011 hasAuthorship W2059462011A5009380500 @default.
• W2059462011 hasConcept C121608353 @default.
• W2059462011 hasConcept C126322002 @default.
• W2059462011 hasConcept C143998085 @default.
• W2059462011 hasConcept C2776530083 @default.
• W2059462011 hasConcept C2776694085 @default.
• W2059462011 hasConcept C2778239845 @default.
• W2059462011 hasConcept C2779387952 @default.
• W2059462011 hasConcept C29730261 @default.
• W2059462011 hasConcept C509974204 @default.
• W2059462011 hasConcept C535046627 @default.
• W2059462011 hasConcept C71924100 @default.
• W2059462011 hasConceptScore W2059462011C121608353 @default.
• W2059462011 hasConceptScore W2059462011C126322002 @default.
• W2059462011 hasConceptScore W2059462011C143998085 @default.
• W2059462011 hasConceptScore W2059462011C2776530083 @default.
• W2059462011 hasConceptScore W2059462011C2776694085 @default.
• W2059462011 hasConceptScore W2059462011C2778239845 @default.
• W2059462011 hasConceptScore W2059462011C2779387952 @default.
• W2059462011 hasConceptScore W2059462011C29730261 @default.
• W2059462011 hasConceptScore W2059462011C509974204 @default.
• W2059462011 hasConceptScore W2059462011C535046627 @default.
• W2059462011 hasConceptScore W2059462011C71924100 @default.
• W2059462011 hasIssue "2" @default.
• W2059462011 hasLocation W20594620111 @default.
• W2059462011 hasLocation W20594620112 @default.
• W2059462011 hasOpenAccess W2059462011 @default.
• W2059462011 hasPrimaryLocation W20594620111 @default.
• W2059462011 hasRelatedWork W151487171 @default.
• W2059462011 hasRelatedWork W1986218825 @default.
• W2059462011 hasRelatedWork W2001825025 @default.
• W2059462011 hasRelatedWork W2059462011 @default.
• W2059462011 hasRelatedWork W2072439407 @default.
• W2059462011 hasRelatedWork W2313027913 @default.
• W2059462011 hasRelatedWork W2359611610 @default.
• W2059462011 hasRelatedWork W2394908553 @default.
• W2059462011 hasRelatedWork W2405171317 @default.
• W2059462011 hasRelatedWork W2460868461 @default.

• next