FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059470894> ?p ?o ?g. }

• W2059470894 endingPage "1066" @default.
• W2059470894 startingPage "1059" @default.
• W2059470894 abstract "Viral capsid dynamics are often observed during infectious events such as cell surface attachment, entry and genome release. Structural analysis of adeno-associated virus (AAV), a helper-dependent parvovirus, revealed a cluster of surface-exposed tyrosine residues at the icosahedral two-fold symmetry axis. We exploited the latter observation to carry out selective oxidation of Tyr residues, which yielded cross-linked viral protein (VP) subunit dimers, effectively stitching together the AAV capsid two-fold interface. Characterization of different Tyr-to-Phe mutants confirmed that the formation of cross-linked VP dimers is mediated by dityrosine adducts and requires the Tyr704 residue, which crosses over from one neighboring VP subunit to the other. When compared to unmodified capsids, Tyr-cross-linked AAV displayed decreased transduction efficiency in cell culture. Surprisingly, further biochemical and quantitative microscopy studies revealed that restraining the two-fold interface hinders externalization of buried VP N-termini, which contain a phospholipase A2 domain and nuclear localization sequences critical for infection. These adverse effects caused by tyrosine oxidation support the notion that interfacial dynamics at the AAV capsid two-fold symmetry axis play a role in externalization of VP N-termini during infection." @default.
• W2059470894 created "2016-06-24" @default.
• W2059470894 creator A5019219512 @default.
• W2059470894 creator A5032114980 @default.
• W2059470894 creator A5032617559 @default.
• W2059470894 date "2012-04-06" @default.
• W2059470894 modified "2023-09-30" @default.
• W2059470894 title "Tyrosine Cross-Linking Reveals Interfacial Dynamics in Adeno-Associated Viral Capsids during Infection" @default.
• W2059470894 cites W1517847098 @default.
• W2059470894 cites W1965086314 @default.
• W2059470894 cites W1965786463 @default.
• W2059470894 cites W1966374792 @default.
• W2059470894 cites W1971386496 @default.
• W2059470894 cites W1974029377 @default.
• W2059470894 cites W2009285158 @default.
• W2059470894 cites W2009455163 @default.
• W2059470894 cites W2022161423 @default.
• W2059470894 cites W2049238377 @default.
• W2059470894 cites W2076660104 @default.
• W2059470894 cites W2083392652 @default.
• W2059470894 cites W2090661761 @default.
• W2059470894 cites W2111767868 @default.
• W2059470894 cites W2119043113 @default.
• W2059470894 cites W2122236774 @default.
• W2059470894 cites W2123260147 @default.
• W2059470894 cites W2123540768 @default.
• W2059470894 cites W2127073503 @default.
• W2059470894 cites W2131971443 @default.
• W2059470894 cites W2136568935 @default.
• W2059470894 cites W2141236766 @default.
• W2059470894 cites W2141797403 @default.
• W2059470894 cites W2149678280 @default.
• W2059470894 cites W2150709214 @default.
• W2059470894 cites W2152134349 @default.
• W2059470894 cites W2153140538 @default.
• W2059470894 cites W2157464327 @default.
• W2059470894 cites W2164625869 @default.
• W2059470894 doi "https://doi.org/10.1021/cb3000265" @default.
• W2059470894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3376196" @default.
• W2059470894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22458529" @default.
• W2059470894 hasPublicationYear "2012" @default.
• W2059470894 type Work @default.
• W2059470894 sameAs 2059470894 @default.
• W2059470894 citedByCount "19" @default.
• W2059470894 countsByYear W20594708942013 @default.
• W2059470894 countsByYear W20594708942014 @default.
• W2059470894 countsByYear W20594708942015 @default.
• W2059470894 countsByYear W20594708942016 @default.
• W2059470894 countsByYear W20594708942017 @default.
• W2059470894 countsByYear W20594708942018 @default.
• W2059470894 countsByYear W20594708942020 @default.
• W2059470894 countsByYear W20594708942022 @default.
• W2059470894 countsByYear W20594708942023 @default.
• W2059470894 crossrefType "journal-article" @default.
• W2059470894 hasAuthorship W2059470894A5019219512 @default.
• W2059470894 hasAuthorship W2059470894A5032114980 @default.
• W2059470894 hasAuthorship W2059470894A5032617559 @default.
• W2059470894 hasBestOaLocation W20594708942 @default.
• W2059470894 hasConcept C104292427 @default.
• W2059470894 hasConcept C104317684 @default.
• W2059470894 hasConcept C12554922 @default.
• W2059470894 hasConcept C159047783 @default.
• W2059470894 hasConcept C185592680 @default.
• W2059470894 hasConcept C202878990 @default.
• W2059470894 hasConcept C2522874641 @default.
• W2059470894 hasConcept C2776165026 @default.
• W2059470894 hasConcept C2779630601 @default.
• W2059470894 hasConcept C55493867 @default.
• W2059470894 hasConcept C86803240 @default.
• W2059470894 hasConcept C95444343 @default.
• W2059470894 hasConceptScore W2059470894C104292427 @default.
• W2059470894 hasConceptScore W2059470894C104317684 @default.
• W2059470894 hasConceptScore W2059470894C12554922 @default.
• W2059470894 hasConceptScore W2059470894C159047783 @default.
• W2059470894 hasConceptScore W2059470894C185592680 @default.
• W2059470894 hasConceptScore W2059470894C202878990 @default.
• W2059470894 hasConceptScore W2059470894C2522874641 @default.
• W2059470894 hasConceptScore W2059470894C2776165026 @default.
• W2059470894 hasConceptScore W2059470894C2779630601 @default.
• W2059470894 hasConceptScore W2059470894C55493867 @default.
• W2059470894 hasConceptScore W2059470894C86803240 @default.
• W2059470894 hasConceptScore W2059470894C95444343 @default.
• W2059470894 hasIssue "6" @default.
• W2059470894 hasLocation W20594708941 @default.
• W2059470894 hasLocation W20594708942 @default.
• W2059470894 hasLocation W20594708943 @default.
• W2059470894 hasLocation W20594708944 @default.
• W2059470894 hasOpenAccess W2059470894 @default.
• W2059470894 hasPrimaryLocation W20594708941 @default.
• W2059470894 hasRelatedWork W1528827813 @default.
• W2059470894 hasRelatedWork W1998047447 @default.
• W2059470894 hasRelatedWork W2039540399 @default.
• W2059470894 hasRelatedWork W2059470894 @default.
• W2059470894 hasRelatedWork W2077508482 @default.
• W2059470894 hasRelatedWork W2079566602 @default.
• W2059470894 hasRelatedWork W2109256632 @default.
• W2059470894 hasRelatedWork W2118087741 @default.
• W2059470894 hasRelatedWork W2130927964 @default.

• next