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• W2059474749 abstract "Retinoblastoma (RB) is extremely rare in adults. We describe a case of RB diagnosed by cytology in a vitrectomy specimen of a 23-year-old patient who presented with diminished visual acuity and retinal detachment in the absence of a clinically-visible mass. Cytological examination of the vitreous fluid showed clusters of loosely cohesive atypical cells with high nuclear to cytoplasmic ratio and salt and pepper chromatin pattern in a background of normal neuronal retinal cells. Nuclear molding was present as well as numerous apoptotic bodies. The cells were focally positive for epithelial markers and showed strong and diffuse positivity for neuroendocrine markers. Ki-67 stained 90% of the atypical cells nuclei, in contrast to nonneoplastic retinal neuronal cells, which were negative for the marker. A diagnosis of RB was rendered, and subsequently was confirmed in the enucleation specimen. The cytological differential diagnosis is discussed as well as the role that cytology and immunohistochemistry can play in differentiating neoplastic cells from normal retinal cellular elements in vitreous fluid specimens." @default.
• W2059474749 created "2016-06-24" @default.
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• W2059474749 date "2009-01-01" @default.
• W2059474749 modified "2023-09-28" @default.
• W2059474749 title "Cytopathological diagnosis of adult retinoblastoma in a vitrectomy specimen" @default.
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• W2059474749 doi "https://doi.org/10.1002/dc.21135" @default.
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• W2059474749 hasPublicationYear "2009" @default.
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