FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059477502> ?p ?o ?g. }

• W2059477502 endingPage "C147" @default.
• W2059477502 startingPage "C137" @default.
• W2059477502 abstract "Mitochondria are increasingly recognized as lynchpins in the evolution of cardiac injury during ischemia and reperfusion. This review addresses the emerging concept that modulation of mitochondrial respiration during and immediately following an episode of ischemia can attenuate the extent of myocardial injury. The blockade of electron transport and the partial uncoupling of respiration are two mechanisms whereby manipulation of mitochondrial metabolism during ischemia decreases cardiac injury. Although protection by inhibition of electron transport or uncoupling of respiration initially appears to be counterintuitive, the continuation of mitochondrial oxidative phosphorylation in the pathological milieu of ischemia generates reactive oxygen species, mitochondrial calcium overload, and the release of cytochrome c. The initial target of these deleterious mitochondrial-driven processes is the mitochondria themselves. Consequences to the cardiomyocyte, in turn, include oxidative damage, the onset of mitochondrial permeability transition, and activation of apoptotic cascades, all favoring cardiomyocyte death. Ischemia-induced mitochondrial damage carried forward into reperfusion further amplifies these mechanisms of mitochondrial-driven myocyte injury. Interruption of mitochondrial respiration during early reperfusion by pharmacologic blockade of electron transport or even recurrent hypoxia or brief ischemia paradoxically decreases cardiac injury. It increasingly appears that the cardioprotective paradigms of ischemic preconditioning and postconditioning utilize modulation of mitochondrial oxidative metabolism as a key effector mechanism. The initially counterintuitive approach to inhibit mitochondrial respiration provides a new cardioprotective paradigm to decrease cellular injury during both ischemia and reperfusion." @default.
• W2059477502 created "2016-06-24" @default.
• W2059477502 creator A5012571820 @default.
• W2059477502 creator A5014524067 @default.
• W2059477502 creator A5035457721 @default.
• W2059477502 creator A5060001839 @default.
• W2059477502 creator A5063050485 @default.
• W2059477502 date "2007-01-01" @default.
• W2059477502 modified "2023-10-15" @default.
• W2059477502 title "Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion" @default.
• W2059477502 cites W10006180 @default.
• W2059477502 cites W150246076 @default.
• W2059477502 cites W1507356284 @default.
• W2059477502 cites W1551289009 @default.
• W2059477502 cites W1562050716 @default.
• W2059477502 cites W1579815423 @default.
• W2059477502 cites W1613264705 @default.
• W2059477502 cites W1728066272 @default.
• W2059477502 cites W1800061482 @default.
• W2059477502 cites W1826167165 @default.
• W2059477502 cites W1857377386 @default.
• W2059477502 cites W1964879817 @default.
• W2059477502 cites W1966104086 @default.
• W2059477502 cites W1968112618 @default.
• W2059477502 cites W1971892333 @default.
• W2059477502 cites W1972113798 @default.
• W2059477502 cites W1975236531 @default.
• W2059477502 cites W1977241569 @default.
• W2059477502 cites W1978211065 @default.
• W2059477502 cites W1978631786 @default.
• W2059477502 cites W1981795365 @default.
• W2059477502 cites W1982007667 @default.
• W2059477502 cites W1982884406 @default.
• W2059477502 cites W1984322976 @default.
• W2059477502 cites W1987219977 @default.
• W2059477502 cites W1989114406 @default.
• W2059477502 cites W1992719639 @default.
• W2059477502 cites W1996867825 @default.
• W2059477502 cites W1997757821 @default.
• W2059477502 cites W1999526484 @default.
• W2059477502 cites W2005139194 @default.
• W2059477502 cites W2005362740 @default.
• W2059477502 cites W2005506628 @default.
• W2059477502 cites W2012763790 @default.
• W2059477502 cites W2016322976 @default.
• W2059477502 cites W2018181106 @default.
• W2059477502 cites W2018228951 @default.
• W2059477502 cites W2018957629 @default.
• W2059477502 cites W2020600203 @default.
• W2059477502 cites W2020937749 @default.
• W2059477502 cites W2021189415 @default.
• W2059477502 cites W2026313838 @default.
• W2059477502 cites W2026525843 @default.
• W2059477502 cites W2027545356 @default.
• W2059477502 cites W2028526641 @default.
• W2059477502 cites W2029130887 @default.
• W2059477502 cites W2029150765 @default.
• W2059477502 cites W2029176648 @default.
• W2059477502 cites W2030837552 @default.
• W2059477502 cites W2033279283 @default.
• W2059477502 cites W2033376988 @default.
• W2059477502 cites W2033599145 @default.
• W2059477502 cites W2036997218 @default.
• W2059477502 cites W2038576287 @default.
• W2059477502 cites W2039330812 @default.
• W2059477502 cites W2040725645 @default.
• W2059477502 cites W2043766237 @default.
• W2059477502 cites W2045919621 @default.
• W2059477502 cites W2047512989 @default.
• W2059477502 cites W2048547503 @default.
• W2059477502 cites W2049043910 @default.
• W2059477502 cites W2049317199 @default.
• W2059477502 cites W2053995474 @default.
• W2059477502 cites W2056892555 @default.
• W2059477502 cites W2057174521 @default.
• W2059477502 cites W2058982127 @default.
• W2059477502 cites W2060800161 @default.
• W2059477502 cites W2063469543 @default.
• W2059477502 cites W2064366111 @default.
• W2059477502 cites W2064522688 @default.
• W2059477502 cites W2070764343 @default.
• W2059477502 cites W2072008984 @default.
• W2059477502 cites W2072763150 @default.
• W2059477502 cites W2074154058 @default.
• W2059477502 cites W2075857100 @default.
• W2059477502 cites W2076582927 @default.
• W2059477502 cites W2077883552 @default.
• W2059477502 cites W2078379844 @default.
• W2059477502 cites W2079438155 @default.
• W2059477502 cites W2080942008 @default.
• W2059477502 cites W2086991052 @default.
• W2059477502 cites W2087261949 @default.
• W2059477502 cites W2087282685 @default.
• W2059477502 cites W2088533676 @default.
• W2059477502 cites W2092718544 @default.
• W2059477502 cites W2095698464 @default.
• W2059477502 cites W2108291280 @default.
• W2059477502 cites W2109004272 @default.

• next