FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059477680> ?p ?o ?g. }

• W2059477680 endingPage "452" @default.
• W2059477680 startingPage "445" @default.
• W2059477680 abstract "Abstract A recently developed chitosan-EDTA conjugate, neutralized with sodium hydroxide (NaChito-EDTA), has been tested for possible topical use. The technical properties and microbial stability of NaChito-EDTA have been compared with those of carmellose sodium (NaCMC), hydroxypropylmethylcellulose (HPMC), sodium polycarbophil (NaPCP) and sodium carbopol 980 (NaC980), well established gelatinizing agents. NaChito-EDTA forms stable, colourless, completely transparent hydrogels at a polymer concentration of 0.5%. Of the polymers tested the novel polymer had the lowest incompatibility with multivalent cations and with ethanol, and much the best swelling properties. After 28 days of incubation at room temperature the rates of growth of the complete bacterial spectrum occurring in demineralized water and of Escherichia coli, serving as model strain representative of Gram-negative bacteria, were at least 2 log and 5–7 log, respectively, lower in NaChito-EDTA gels than in the other hydrogels. This antimicrobial activity of NaChito-EDTA can be explained by its highest binding affinity towards magnesium, which stabilizes the outer membrane of Gram-negative bacteria. However, this antimicrobial effect is insufficient to guarantee microbial stability. Further results showed that the antimicrobially acting polypeptide nisin can be recommended as an alternative novel preservative for NaChito-EDTA gels, because its antimicrobial spectrum could also be increased towards Gram-negative bacteria in combination with chelating excipients. NaChito-EDTA seems, therefore, to be a promising novel polymer for topically-used gels, with advantages over well established gelatinizing agents." @default.
• W2059477680 created "2016-06-24" @default.
• W2059477680 creator A5018116917 @default.
• W2059477680 creator A5035632031 @default.
• W2059477680 creator A5073475063 @default.
• W2059477680 date "1998-05-01" @default.
• W2059477680 modified "2023-10-12" @default.
• W2059477680 title "Chitosan-EDTA Conjugate: A Novel Polymer for Topical Gels" @default.
• W2059477680 cites W1506273512 @default.
• W2059477680 cites W1543196425 @default.
• W2059477680 cites W1571045414 @default.
• W2059477680 cites W1585404684 @default.
• W2059477680 cites W1963711619 @default.
• W2059477680 cites W1967377331 @default.
• W2059477680 cites W2035207357 @default.
• W2059477680 cites W2060923836 @default.
• W2059477680 cites W2063167019 @default.
• W2059477680 cites W2071542235 @default.
• W2059477680 cites W2081274806 @default.
• W2059477680 cites W2084413504 @default.
• W2059477680 cites W2084623901 @default.
• W2059477680 cites W2089126329 @default.
• W2059477680 cites W2125002907 @default.
• W2059477680 cites W2155528425 @default.
• W2059477680 cites W2164450230 @default.
• W2059477680 doi "https://doi.org/10.1111/j.2042-7158.1998.tb06184.x" @default.
• W2059477680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9643436" @default.
• W2059477680 hasPublicationYear "1998" @default.
• W2059477680 type Work @default.
• W2059477680 sameAs 2059477680 @default.
• W2059477680 citedByCount "58" @default.
• W2059477680 countsByYear W20594776802012 @default.
• W2059477680 countsByYear W20594776802013 @default.
• W2059477680 countsByYear W20594776802014 @default.
• W2059477680 countsByYear W20594776802015 @default.
• W2059477680 countsByYear W20594776802016 @default.
• W2059477680 countsByYear W20594776802017 @default.
• W2059477680 countsByYear W20594776802018 @default.
• W2059477680 countsByYear W20594776802019 @default.
• W2059477680 countsByYear W20594776802020 @default.
• W2059477680 countsByYear W20594776802021 @default.
• W2059477680 countsByYear W20594776802022 @default.
• W2059477680 crossrefType "journal-article" @default.
• W2059477680 hasAuthorship W2059477680A5018116917 @default.
• W2059477680 hasAuthorship W2059477680A5035632031 @default.
• W2059477680 hasAuthorship W2059477680A5073475063 @default.
• W2059477680 hasConcept C108586683 @default.
• W2059477680 hasConcept C134306372 @default.
• W2059477680 hasConcept C13965031 @default.
• W2059477680 hasConcept C178790620 @default.
• W2059477680 hasConcept C185592680 @default.
• W2059477680 hasConcept C188027245 @default.
• W2059477680 hasConcept C197336794 @default.
• W2059477680 hasConcept C197404232 @default.
• W2059477680 hasConcept C2779732960 @default.
• W2059477680 hasConcept C33923547 @default.
• W2059477680 hasConcept C43617362 @default.
• W2059477680 hasConcept C4937899 @default.
• W2059477680 hasConcept C521977710 @default.
• W2059477680 hasConcept C537181965 @default.
• W2059477680 hasConcept C543218039 @default.
• W2059477680 hasConcept C55493867 @default.
• W2059477680 hasConcept C67031304 @default.
• W2059477680 hasConceptScore W2059477680C108586683 @default.
• W2059477680 hasConceptScore W2059477680C134306372 @default.
• W2059477680 hasConceptScore W2059477680C13965031 @default.
• W2059477680 hasConceptScore W2059477680C178790620 @default.
• W2059477680 hasConceptScore W2059477680C185592680 @default.
• W2059477680 hasConceptScore W2059477680C188027245 @default.
• W2059477680 hasConceptScore W2059477680C197336794 @default.
• W2059477680 hasConceptScore W2059477680C197404232 @default.
• W2059477680 hasConceptScore W2059477680C2779732960 @default.
• W2059477680 hasConceptScore W2059477680C33923547 @default.
• W2059477680 hasConceptScore W2059477680C43617362 @default.
• W2059477680 hasConceptScore W2059477680C4937899 @default.
• W2059477680 hasConceptScore W2059477680C521977710 @default.
• W2059477680 hasConceptScore W2059477680C537181965 @default.
• W2059477680 hasConceptScore W2059477680C543218039 @default.
• W2059477680 hasConceptScore W2059477680C55493867 @default.
• W2059477680 hasConceptScore W2059477680C67031304 @default.
• W2059477680 hasIssue "5" @default.
• W2059477680 hasLocation W20594776801 @default.
• W2059477680 hasLocation W20594776802 @default.
• W2059477680 hasOpenAccess W2059477680 @default.
• W2059477680 hasPrimaryLocation W20594776801 @default.
• W2059477680 hasRelatedWork W1990468524 @default.
• W2059477680 hasRelatedWork W2086842725 @default.
• W2059477680 hasRelatedWork W2134563742 @default.
• W2059477680 hasRelatedWork W2360679599 @default.
• W2059477680 hasRelatedWork W2365180341 @default.
• W2059477680 hasRelatedWork W2405986450 @default.
• W2059477680 hasRelatedWork W2469867823 @default.
• W2059477680 hasRelatedWork W3117759558 @default.
• W2059477680 hasRelatedWork W3160667113 @default.
• W2059477680 hasRelatedWork W3217274898 @default.
• W2059477680 hasVolume "50" @default.
• W2059477680 isParatext "false" @default.
• W2059477680 isRetracted "false" @default.

• next