FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059481007> ?p ?o ?g. }

• W2059481007 endingPage "238" @default.
• W2059481007 startingPage "233" @default.
• W2059481007 abstract "Summary Thrombotic thrombocytopenic purpura (TTP) is a rare and severe disease characterized by thrombocytopenia, microangiopathic haemolytic anemia, neurological and renal involvement associated with deficiency of the von Willebrand factor-cleaving protease, ADAMTS13. Persistence of high titers of anti-ADAMTS13 autoantibodies predisposes to relapsing TTP. Since relapses are associated with high morbidity and mortality rates, the optimal therapeutic option should be a pre-emptive treatment able to deplete anti-ADAMTS13 autoantibodies and avoid relapses. Five patients who presented with persistence of undetectable ADAMTS13 activity and high titers of autoantibodies, were treated with rituximab as pre-emptive therapy during remission. Four of them were affected by relapsing TTP and one was treated after the first episode. ADAMTS13 activity ranging from 15% to 75% with disappearance of inhibitors was achieved after three months in all patients, and persisted >20% without inhibitors at six months. In three patients disease-free status is still ongoing after 29, 24 and six months, respectively. Relapses were documented in two patients during follow-up: in one patient remission lasted 51 months; while in the other patient relapse occurred after 13 months. Results demonstrated that rituximab used as pre-emptive treatment may be effective in maintaining a sustained remission in patients with anti-ADAMTS13 antibodies in whom other treatments failed to limit the production of inhibitors, and suggests that re-treatment with rituximab should be considered when ADAMTS13 activity decreases and inhibitors reappear into the circulation, to avoid a new relapse." @default.
• W2059481007 created "2016-06-24" @default.
• W2059481007 creator A5005558035 @default.
• W2059481007 creator A5023556434 @default.
• W2059481007 creator A5027526895 @default.
• W2059481007 creator A5035335560 @default.
• W2059481007 creator A5040397073 @default.
• W2059481007 creator A5045803218 @default.
• W2059481007 creator A5054027791 @default.
• W2059481007 creator A5054193089 @default.
• W2059481007 creator A5066180999 @default.
• W2059481007 creator A5086275620 @default.
• W2059481007 creator A5086863291 @default.
• W2059481007 date "2009-01-01" @default.
• W2059481007 modified "2023-10-13" @default.
• W2059481007 title "Rituximab as pre-emptive treatment in patients with thrombotic thrombocytopenic purpura and evidence of anti-ADAMTS13 autoantibodies" @default.
• W2059481007 cites W1790495991 @default.
• W2059481007 cites W1796120472 @default.
• W2059481007 cites W1968875627 @default.
• W2059481007 cites W1968889356 @default.
• W2059481007 cites W1977622626 @default.
• W2059481007 cites W1980762761 @default.
• W2059481007 cites W2006456576 @default.
• W2059481007 cites W2015353972 @default.
• W2059481007 cites W2015445458 @default.
• W2059481007 cites W2020077683 @default.
• W2059481007 cites W2026324493 @default.
• W2059481007 cites W2028492855 @default.
• W2059481007 cites W2041065426 @default.
• W2059481007 cites W2050733195 @default.
• W2059481007 cites W2056427896 @default.
• W2059481007 cites W2058075712 @default.
• W2059481007 cites W2063563163 @default.
• W2059481007 cites W2071998860 @default.
• W2059481007 cites W2077882848 @default.
• W2059481007 cites W2087718777 @default.
• W2059481007 cites W2089916413 @default.
• W2059481007 cites W2090857284 @default.
• W2059481007 cites W2093312854 @default.
• W2059481007 cites W2101061562 @default.
• W2059481007 cites W2102545046 @default.
• W2059481007 cites W2102997173 @default.
• W2059481007 cites W2104483045 @default.
• W2059481007 cites W2114979410 @default.
• W2059481007 cites W2121848782 @default.
• W2059481007 cites W2133648811 @default.
• W2059481007 cites W2135676423 @default.
• W2059481007 cites W2141774413 @default.
• W2059481007 cites W2142415495 @default.
• W2059481007 cites W2145427481 @default.
• W2059481007 cites W2170134021 @default.
• W2059481007 cites W2170180644 @default.
• W2059481007 cites W2186355732 @default.
• W2059481007 cites W2315229770 @default.
• W2059481007 cites W2340760838 @default.
• W2059481007 cites W3147102246 @default.
• W2059481007 doi "https://doi.org/10.1160/th07-12-0753" @default.
• W2059481007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19190804" @default.
• W2059481007 hasPublicationYear "2009" @default.
• W2059481007 type Work @default.
• W2059481007 sameAs 2059481007 @default.
• W2059481007 citedByCount "82" @default.
• W2059481007 countsByYear W20594810072012 @default.
• W2059481007 countsByYear W20594810072013 @default.
• W2059481007 countsByYear W20594810072014 @default.
• W2059481007 countsByYear W20594810072015 @default.
• W2059481007 countsByYear W20594810072016 @default.
• W2059481007 countsByYear W20594810072017 @default.
• W2059481007 countsByYear W20594810072018 @default.
• W2059481007 countsByYear W20594810072019 @default.
• W2059481007 countsByYear W20594810072020 @default.
• W2059481007 countsByYear W20594810072021 @default.
• W2059481007 countsByYear W20594810072022 @default.
• W2059481007 countsByYear W20594810072023 @default.
• W2059481007 crossrefType "journal-article" @default.
• W2059481007 hasAuthorship W2059481007A5005558035 @default.
• W2059481007 hasAuthorship W2059481007A5023556434 @default.
• W2059481007 hasAuthorship W2059481007A5027526895 @default.
• W2059481007 hasAuthorship W2059481007A5035335560 @default.
• W2059481007 hasAuthorship W2059481007A5040397073 @default.
• W2059481007 hasAuthorship W2059481007A5045803218 @default.
• W2059481007 hasAuthorship W2059481007A5054027791 @default.
• W2059481007 hasAuthorship W2059481007A5054193089 @default.
• W2059481007 hasAuthorship W2059481007A5066180999 @default.
• W2059481007 hasAuthorship W2059481007A5086275620 @default.
• W2059481007 hasAuthorship W2059481007A5086863291 @default.
• W2059481007 hasConcept C126322002 @default.
• W2059481007 hasConcept C159654299 @default.
• W2059481007 hasConcept C163764329 @default.
• W2059481007 hasConcept C203014093 @default.
• W2059481007 hasConcept C2778585876 @default.
• W2059481007 hasConcept C2778842783 @default.
• W2059481007 hasConcept C2779394231 @default.
• W2059481007 hasConcept C2780653079 @default.
• W2059481007 hasConcept C2780921031 @default.
• W2059481007 hasConcept C2781127562 @default.
• W2059481007 hasConcept C71924100 @default.
• W2059481007 hasConcept C89560881 @default.

• next