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- W2059486139 abstract "Carboxypeptidase N (CPN) is a plasma zinc metalloprotease, which consists of two enzymatically active small subunits (CPN1) and two large subunits (CPN2) that protect the protein from degradation. CPN cleaves carboxy-terminal arginines and lysines from peptides found in the bloodstream such as complement anaphylatoxins, kinins, and creatine kinase MM (CK-MM). By removing only one amino acid, CPN has the ability to change peptide activity and receptor binding. CPN is a member of a larger family of carboxypeptidases, many of which also cleave arginine and lysine. Because of the highly conserved active sites and the possible redundant functions of carboxypeptidases, it has been difficult to elucidate the role of CPN in disease processes. The future use of gene ablation technology may be the most appropriate way to understand the function of CPN in vivo." @default.
- W2059486139 created "2016-06-24" @default.
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- W2059486139 date "2004-01-01" @default.
- W2059486139 modified "2023-10-07" @default.
- W2059486139 title "Carboxypeptidase N: a pleiotropic regulator of inflammation" @default.
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- W2059486139 doi "https://doi.org/10.1016/j.molimm.2003.10.002" @default.
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