FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059492547> ?p ?o ?g. }

• W2059492547 endingPage "33706" @default.
• W2059492547 startingPage "33701" @default.
• W2059492547 abstract "Vascular calcification impairs vessel compliance and increases the risk of cardiovascular events. We found previously that liver X receptor agonists, which regulate intracellular cholesterol homeostasis, augment PKA agonist- or high phosphate-induced osteogenic differentiation of vascular smooth muscle cells. Because cholesterol is an integral component of the matrix vesicles that nucleate calcium mineral, we examined the role of cellular cholesterol metabolism in vascular cell mineralization. The results showed that vascular smooth muscle cells isolated from LDL receptor null (Ldlr(-/-)) mice, which have impaired cholesterol uptake, had lower levels of intracellular cholesterol and less osteogenic differentiation, as indicated by alkaline phosphatase activity and matrix mineralization, compared with WT cells. PKA activation with forskolin acutely induced genes that promote cholesterol uptake (LDL receptor) and biosynthesis (HMG-CoA reductase). In WT cells, inhibition of cholesterol uptake by lipoprotein-deficient serum attenuated forskolin-induced matrix mineralization, which was partially reversed by the addition of cell-permeable cholesterol. Prolonged activation of both uptake and biosynthesis pathways by cotreatment with a liver X receptor agonist further augmented forskolin-induced matrix mineralization. Inhibition of either cholesterol uptake, using Ldlr(-/-) cells, or of cholesterol biosynthesis, using mevastatin-treated WT cells, failed to inhibit matrix mineralization due to up-regulation of the respective compensatory pathway. Inhibition of both pathways simultaneously using mevastatin-treated Ldlr(-/-) cells did inhibit forskolin-induced matrix mineralization. Altogether, the results suggest that up-regulation of cholesterol metabolism is essential for matrix mineralization by vascular cells." @default.
• W2059492547 created "2016-06-24" @default.
• W2059492547 creator A5022212518 @default.
• W2059492547 creator A5032236530 @default.
• W2059492547 creator A5059995837 @default.
• W2059492547 creator A5062002883 @default.
• W2059492547 creator A5062873812 @default.
• W2059492547 creator A5070518459 @default.
• W2059492547 creator A5090431009 @default.
• W2059492547 date "2011-09-01" @default.
• W2059492547 modified "2023-09-30" @default.
• W2059492547 title "Role of Cellular Cholesterol Metabolism in Vascular Cell Calcification" @default.
• W2059492547 cites W1966856123 @default.
• W2059492547 cites W1973895552 @default.
• W2059492547 cites W1978271794 @default.
• W2059492547 cites W1995032745 @default.
• W2059492547 cites W2000944182 @default.
• W2059492547 cites W2009460052 @default.
• W2059492547 cites W2011757963 @default.
• W2059492547 cites W2017871510 @default.
• W2059492547 cites W2023846584 @default.
• W2059492547 cites W2026587556 @default.
• W2059492547 cites W2034712955 @default.
• W2059492547 cites W2040641918 @default.
• W2059492547 cites W2040780797 @default.
• W2059492547 cites W2042792668 @default.
• W2059492547 cites W2051575384 @default.
• W2059492547 cites W2056412036 @default.
• W2059492547 cites W2072196650 @default.
• W2059492547 cites W2080447461 @default.
• W2059492547 cites W2095206475 @default.
• W2059492547 cites W2119790151 @default.
• W2059492547 cites W2125001301 @default.
• W2059492547 cites W2146662079 @default.
• W2059492547 cites W2148413329 @default.
• W2059492547 cites W2159332620 @default.
• W2059492547 cites W2159805885 @default.
• W2059492547 cites W2162664654 @default.
• W2059492547 cites W2165853103 @default.
• W2059492547 cites W2170893247 @default.
• W2059492547 doi "https://doi.org/10.1074/jbc.m111.269639" @default.
• W2059492547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3190941" @default.
• W2059492547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21835914" @default.
• W2059492547 hasPublicationYear "2011" @default.
• W2059492547 type Work @default.
• W2059492547 sameAs 2059492547 @default.
• W2059492547 citedByCount "28" @default.
• W2059492547 countsByYear W20594925472012 @default.
• W2059492547 countsByYear W20594925472013 @default.
• W2059492547 countsByYear W20594925472014 @default.
• W2059492547 countsByYear W20594925472015 @default.
• W2059492547 countsByYear W20594925472016 @default.
• W2059492547 countsByYear W20594925472017 @default.
• W2059492547 countsByYear W20594925472018 @default.
• W2059492547 countsByYear W20594925472019 @default.
• W2059492547 countsByYear W20594925472020 @default.
• W2059492547 countsByYear W20594925472021 @default.
• W2059492547 countsByYear W20594925472023 @default.
• W2059492547 crossrefType "journal-article" @default.
• W2059492547 hasAuthorship W2059492547A5022212518 @default.
• W2059492547 hasAuthorship W2059492547A5032236530 @default.
• W2059492547 hasAuthorship W2059492547A5059995837 @default.
• W2059492547 hasAuthorship W2059492547A5062002883 @default.
• W2059492547 hasAuthorship W2059492547A5062873812 @default.
• W2059492547 hasAuthorship W2059492547A5070518459 @default.
• W2059492547 hasAuthorship W2059492547A5090431009 @default.
• W2059492547 hasBestOaLocation W20594925471 @default.
• W2059492547 hasConcept C110459506 @default.
• W2059492547 hasConcept C126322002 @default.
• W2059492547 hasConcept C134018914 @default.
• W2059492547 hasConcept C170493617 @default.
• W2059492547 hasConcept C185592680 @default.
• W2059492547 hasConcept C2778163477 @default.
• W2059492547 hasConcept C2779276759 @default.
• W2059492547 hasConcept C2779395532 @default.
• W2059492547 hasConcept C2780072125 @default.
• W2059492547 hasConcept C2992686903 @default.
• W2059492547 hasConcept C55493867 @default.
• W2059492547 hasConcept C71924100 @default.
• W2059492547 hasConcept C86803240 @default.
• W2059492547 hasConcept C95444343 @default.
• W2059492547 hasConceptScore W2059492547C110459506 @default.
• W2059492547 hasConceptScore W2059492547C126322002 @default.
• W2059492547 hasConceptScore W2059492547C134018914 @default.
• W2059492547 hasConceptScore W2059492547C170493617 @default.
• W2059492547 hasConceptScore W2059492547C185592680 @default.
• W2059492547 hasConceptScore W2059492547C2778163477 @default.
• W2059492547 hasConceptScore W2059492547C2779276759 @default.
• W2059492547 hasConceptScore W2059492547C2779395532 @default.
• W2059492547 hasConceptScore W2059492547C2780072125 @default.
• W2059492547 hasConceptScore W2059492547C2992686903 @default.
• W2059492547 hasConceptScore W2059492547C55493867 @default.
• W2059492547 hasConceptScore W2059492547C71924100 @default.
• W2059492547 hasConceptScore W2059492547C86803240 @default.
• W2059492547 hasConceptScore W2059492547C95444343 @default.
• W2059492547 hasIssue "38" @default.
• W2059492547 hasLocation W20594925471 @default.
• W2059492547 hasLocation W20594925472 @default.

• next