FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059504131> ?p ?o ?g. }

• W2059504131 endingPage "450" @default.
• W2059504131 startingPage "445" @default.
• W2059504131 abstract "Enhancement of the cytotoxicity of cytosine arabinoside (ara-C) by granulocyte/macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), and the mechanisms involved, were studied in the AML-193 human leukemia cell line. AML-193 cells require GM-CSF and G-CSF(CSFs) for optimum growth, and 24 h deprivation of CSFs decreased DNA synthesis measured in terms of 3H-thymidine incorporation. The DNA synthesis gradually recovered upon addition of CSFs. To examine the sensitivity to ara-C under different growth conditions, two groups of cell suspensions, one pretreated with CSFs after 24 h deprivation (CSFs(+) cells), and the other held continuously under CSFs-free conditions (CSFs(-) cells), were exposed to 1.0 μg/ml of ara-C for 16 h. In clonogenic assays, CSFs(+) cells showed higher sensitivity to ara-C than CSFs(-) cells. These cell groups showed no significant difference in ara-C triphosphate accumulation or retention, though the amount of ara-C incorporated into the acid-insoluble fraction was two times greater in CSFs(+) cells than CSFs(-) cells, and that difference became even clearer in the retention pools. These data suggest that the enhancement of cytotoxicity by CSFs was due to the promotion of ara-C incorporation into DNA as a result of an increase of the cell fraction in the S phase." @default.
• W2059504131 created "2016-06-24" @default.
• W2059504131 creator A5010889630 @default.
• W2059504131 creator A5011340584 @default.
• W2059504131 creator A5059412860 @default.
• W2059504131 creator A5060744842 @default.
• W2059504131 date "1993-04-01" @default.
• W2059504131 modified "2023-10-17" @default.
• W2059504131 title "Enhancement of Cytosine Arabinoside Cytotoxicity by Granulocyte/Macrophage Colony-stimulating Factor and Granulocyte Colony-stimulating Factor in a Human Myeloblastic Leukemia Cell Line" @default.
• W2059504131 cites W1556132176 @default.
• W2059504131 cites W1584304412 @default.
• W2059504131 cites W1600331527 @default.
• W2059504131 cites W1966113396 @default.
• W2059504131 cites W1975625601 @default.
• W2059504131 cites W198522398 @default.
• W2059504131 cites W1992539966 @default.
• W2059504131 cites W2006416369 @default.
• W2059504131 cites W2011685655 @default.
• W2059504131 cites W2029938020 @default.
• W2059504131 cites W2087258490 @default.
• W2059504131 cites W2092953524 @default.
• W2059504131 cites W2093860395 @default.
• W2059504131 cites W2096725836 @default.
• W2059504131 cites W2131473800 @default.
• W2059504131 cites W2149083534 @default.
• W2059504131 cites W2152610325 @default.
• W2059504131 cites W2244390199 @default.
• W2059504131 cites W2334378889 @default.
• W2059504131 cites W2403598312 @default.
• W2059504131 cites W2409228037 @default.
• W2059504131 cites W2464812426 @default.
• W2059504131 cites W2466879131 @default.
• W2059504131 cites W4235771239 @default.
• W2059504131 cites W64631301 @default.
• W2059504131 cites W1837285654 @default.
• W2059504131 doi "https://doi.org/10.1111/j.1349-7006.1993.tb00156.x" @default.
• W2059504131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5919314" @default.
• W2059504131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7685751" @default.
• W2059504131 hasPublicationYear "1993" @default.
• W2059504131 type Work @default.
• W2059504131 sameAs 2059504131 @default.
• W2059504131 citedByCount "8" @default.
• W2059504131 countsByYear W20595041312018 @default.
• W2059504131 crossrefType "journal-article" @default.
• W2059504131 hasAuthorship W2059504131A5010889630 @default.
• W2059504131 hasAuthorship W2059504131A5011340584 @default.
• W2059504131 hasAuthorship W2059504131A5059412860 @default.
• W2059504131 hasAuthorship W2059504131A5060744842 @default.
• W2059504131 hasBestOaLocation W20595041311 @default.
• W2059504131 hasConcept C109316439 @default.
• W2059504131 hasConcept C117262875 @default.
• W2059504131 hasConcept C126322002 @default.
• W2059504131 hasConcept C1491633281 @default.
• W2059504131 hasConcept C153911025 @default.
• W2059504131 hasConcept C185592680 @default.
• W2059504131 hasConcept C202751555 @default.
• W2059504131 hasConcept C203014093 @default.
• W2059504131 hasConcept C2776694085 @default.
• W2059504131 hasConcept C2777478134 @default.
• W2059504131 hasConcept C2777767877 @default.
• W2059504131 hasConcept C2777983669 @default.
• W2059504131 hasConcept C2778041864 @default.
• W2059504131 hasConcept C2778461978 @default.
• W2059504131 hasConcept C2778690821 @default.
• W2059504131 hasConcept C2779378344 @default.
• W2059504131 hasConcept C54355233 @default.
• W2059504131 hasConcept C55493867 @default.
• W2059504131 hasConcept C64241487 @default.
• W2059504131 hasConcept C71924100 @default.
• W2059504131 hasConcept C81885089 @default.
• W2059504131 hasConcept C86803240 @default.
• W2059504131 hasConceptScore W2059504131C109316439 @default.
• W2059504131 hasConceptScore W2059504131C117262875 @default.
• W2059504131 hasConceptScore W2059504131C126322002 @default.
• W2059504131 hasConceptScore W2059504131C1491633281 @default.
• W2059504131 hasConceptScore W2059504131C153911025 @default.
• W2059504131 hasConceptScore W2059504131C185592680 @default.
• W2059504131 hasConceptScore W2059504131C202751555 @default.
• W2059504131 hasConceptScore W2059504131C203014093 @default.
• W2059504131 hasConceptScore W2059504131C2776694085 @default.
• W2059504131 hasConceptScore W2059504131C2777478134 @default.
• W2059504131 hasConceptScore W2059504131C2777767877 @default.
• W2059504131 hasConceptScore W2059504131C2777983669 @default.
• W2059504131 hasConceptScore W2059504131C2778041864 @default.
• W2059504131 hasConceptScore W2059504131C2778461978 @default.
• W2059504131 hasConceptScore W2059504131C2778690821 @default.
• W2059504131 hasConceptScore W2059504131C2779378344 @default.
• W2059504131 hasConceptScore W2059504131C54355233 @default.
• W2059504131 hasConceptScore W2059504131C55493867 @default.
• W2059504131 hasConceptScore W2059504131C64241487 @default.
• W2059504131 hasConceptScore W2059504131C71924100 @default.
• W2059504131 hasConceptScore W2059504131C81885089 @default.
• W2059504131 hasConceptScore W2059504131C86803240 @default.
• W2059504131 hasIssue "4" @default.
• W2059504131 hasLocation W20595041311 @default.
• W2059504131 hasLocation W20595041312 @default.
• W2059504131 hasLocation W20595041313 @default.
• W2059504131 hasLocation W20595041314 @default.

• next