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- W2059513513 abstract "The site of increased collagen synthetic activity in aortas from rabbits fed a 2% cholesterol diet was investigated. After 70 days control and experimental animals were killed and the intima-media was carefully separated from the adventitia. Collagen and non-collagen protein synthetic rates were estimated following in vitro incorporation of [14C]proline. All of the cholesterol fed rabbits had lesions in the intima-media layer with little or no involvement of the adventitia. The intima-media demonstrated a greater increase in collagen and non-collagen protein synthetic activity than that observed in the media-adventitia. Since the greatest accumulation of cholesterol and cholesterol-esters occurred in the intima-media, the data suggests that the observed alteration in collagen and non-collagen protein synthesis represents a localized response to cholesterol deposition, rather than a generalized response occurring throughout the arterial wall." @default.
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- W2059513513 date "1979-10-01" @default.
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- W2059513513 title "The effect of cholesterol feeding on protein synthesis in different regions of the rabbit arterial wall" @default.
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- W2059513513 doi "https://doi.org/10.1016/0014-4800(79)90032-7" @default.
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