FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059524717> ?p ?o ?g. }

• W2059524717 endingPage "910" @default.
• W2059524717 startingPage "902" @default.
• W2059524717 abstract "There is increasing evidence that multiple chromosomal rearrangements occur in prostate cancer. PTEN loss is considered to be a key event in prostate carcinogenesis but the mechanisms of loss remain to be fully elucidated. We hypothesised that gross rearrangements may exist that cause disruption of the PTEN gene in the absence of genomic deletion. We therefore designed a novel fluorescence in situ hybridisation (FISH) assay with probes overlying regions 3′ and 5′ of PTEN and a third probe overlying the gene. We aimed to identify both genomic deletions and gross rearrangements of PTEN that would be overlooked by previously reported single-probe FISH assays. We proceeded to evaluate a tissue microarray with radical prostatectomy and trans-urethral resection of the prostate specimens from 187 patients. We identified PTEN genomic loss in 45/150 (30%) radical prostatectomy patients and 16/37 (43%) trans-urethral resection of the prostate patients. Importantly, our assay detected novel chromosomal alterations in the PTEN gene (characterised by splitting of FISH signals) in 13 tumours (6.9% of all prostate cancers; 21% of PTEN-lost cancers). All PTEN-rearranged tumours had genomic loss at the other allele and had no expression of PTEN by immunohistochemistry. PTEN-rearranged tumours were significantly more likely to have an underlying ERG rearrangement. Our assay differentiated loss of the probe overlying PTEN in isolation or in combination with either one of or both the probes overlying the 3′ and 5′ regions. This gave an indication of the size of genomic loss and we observed considerable inter-tumoural heterogeneity in the extent of genomic loss in PTEN-lost tumours. In summary, gross rearrangements of the PTEN locus occur in prostate cancer and can be detected by a ‘break-apart' FISH assay. This observation could explain the absence of PTEN protein expression in a subgroup of tumours previously classified as having heterozygous genomic loss using single-probe traditional FISH assays." @default.
• W2059524717 created "2016-06-24" @default.
• W2059524717 creator A5000156180 @default.
• W2059524717 creator A5027776246 @default.
• W2059524717 creator A5031621086 @default.
• W2059524717 creator A5035187235 @default.
• W2059524717 creator A5038860768 @default.
• W2059524717 creator A5041440680 @default.
• W2059524717 creator A5058113107 @default.
• W2059524717 creator A5062820099 @default.
• W2059524717 creator A5066136399 @default.
• W2059524717 creator A5070033129 @default.
• W2059524717 creator A5070573139 @default.
• W2059524717 creator A5072378199 @default.
• W2059524717 creator A5076516070 @default.
• W2059524717 creator A5077437255 @default.
• W2059524717 creator A5088971353 @default.
• W2059524717 creator A5089885816 @default.
• W2059524717 date "2012-06-01" @default.
• W2059524717 modified "2023-10-17" @default.
• W2059524717 title "Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer" @default.
• W2059524717 cites W1964252337 @default.
• W2059524717 cites W1971081363 @default.
• W2059524717 cites W1996513019 @default.
• W2059524717 cites W2003626435 @default.
• W2059524717 cites W2004477123 @default.
• W2059524717 cites W2005841299 @default.
• W2059524717 cites W2020016182 @default.
• W2059524717 cites W2021466588 @default.
• W2059524717 cites W2023011880 @default.
• W2059524717 cites W2029575024 @default.
• W2059524717 cites W2049205984 @default.
• W2059524717 cites W2060739426 @default.
• W2059524717 cites W2077582389 @default.
• W2059524717 cites W2079738717 @default.
• W2059524717 cites W2087207490 @default.
• W2059524717 cites W2087618393 @default.
• W2059524717 cites W2100237319 @default.
• W2059524717 cites W2107633226 @default.
• W2059524717 cites W2116005493 @default.
• W2059524717 cites W2117936087 @default.
• W2059524717 cites W2121158863 @default.
• W2059524717 cites W2123151929 @default.
• W2059524717 cites W2129583552 @default.
• W2059524717 cites W2135721953 @default.
• W2059524717 cites W2137250030 @default.
• W2059524717 cites W2149307190 @default.
• W2059524717 cites W2154165363 @default.
• W2059524717 cites W2159715390 @default.
• W2059524717 cites W2161405893 @default.
• W2059524717 cites W2169599916 @default.
• W2059524717 cites W2171972386 @default.
• W2059524717 doi "https://doi.org/10.1038/modpathol.2011.207" @default.
• W2059524717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22460813" @default.
• W2059524717 hasPublicationYear "2012" @default.
• W2059524717 type Work @default.
• W2059524717 sameAs 2059524717 @default.
• W2059524717 citedByCount "43" @default.
• W2059524717 countsByYear W20595247172013 @default.
• W2059524717 countsByYear W20595247172014 @default.
• W2059524717 countsByYear W20595247172015 @default.
• W2059524717 countsByYear W20595247172016 @default.
• W2059524717 countsByYear W20595247172017 @default.
• W2059524717 countsByYear W20595247172018 @default.
• W2059524717 countsByYear W20595247172019 @default.
• W2059524717 countsByYear W20595247172021 @default.
• W2059524717 crossrefType "journal-article" @default.
• W2059524717 hasAuthorship W2059524717A5000156180 @default.
• W2059524717 hasAuthorship W2059524717A5027776246 @default.
• W2059524717 hasAuthorship W2059524717A5031621086 @default.
• W2059524717 hasAuthorship W2059524717A5035187235 @default.
• W2059524717 hasAuthorship W2059524717A5038860768 @default.
• W2059524717 hasAuthorship W2059524717A5041440680 @default.
• W2059524717 hasAuthorship W2059524717A5058113107 @default.
• W2059524717 hasAuthorship W2059524717A5062820099 @default.
• W2059524717 hasAuthorship W2059524717A5066136399 @default.
• W2059524717 hasAuthorship W2059524717A5070033129 @default.
• W2059524717 hasAuthorship W2059524717A5070573139 @default.
• W2059524717 hasAuthorship W2059524717A5072378199 @default.
• W2059524717 hasAuthorship W2059524717A5076516070 @default.
• W2059524717 hasAuthorship W2059524717A5077437255 @default.
• W2059524717 hasAuthorship W2059524717A5088971353 @default.
• W2059524717 hasAuthorship W2059524717A5089885816 @default.
• W2059524717 hasBestOaLocation W20595247171 @default.
• W2059524717 hasConcept C104317684 @default.
• W2059524717 hasConcept C121608353 @default.
• W2059524717 hasConcept C124942203 @default.
• W2059524717 hasConcept C141231307 @default.
• W2059524717 hasConcept C142724271 @default.
• W2059524717 hasConcept C190283241 @default.
• W2059524717 hasConcept C193270364 @default.
• W2059524717 hasConcept C2776235491 @default.
• W2059524717 hasConcept C2777542201 @default.
• W2059524717 hasConcept C2777609662 @default.
• W2059524717 hasConcept C2778264664 @default.
• W2059524717 hasConcept C2779466945 @default.
• W2059524717 hasConcept C2780192828 @default.
• W2059524717 hasConcept C30481170 @default.

• next