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- W2059531879 abstract "Measuring diagnostic panels of multiple proteins promises a new, personalized approach to early detection and therapy of diseases like cancer. Levels of biomarker proteins in patient serum can provide a continually updated record of disease status. Research in electrochemical detection of proteins has produced exquisitely sensitive approaches. Most utilize ELISA-like sandwich immunoassays incorporating various aspects of nanotechnology. Several of these ultrasensitive methodologies have been extended to microfluidic multiplexed protein detection, but engineered solutions are needed to measure more proteins in a single device from a small patient sample such as a drop of blood or tissue lysate. To achieve clinical or point-of-care (POC) use, simplicity and low cost are essential. In multiplexed microfluidic immunoassays, required reagent additions and washing steps pose a significant problem calling for creative engineering. A grand challenge is to develop a general cancer screening device to accurately measure 50-100 proteins in a simple, cost-effective fashion. This will require creative solutions to simplified reagent addition and multiplexing." @default.
- W2059531879 created "2016-06-24" @default.
- W2059531879 creator A5086925649 @default.
- W2059531879 date "2013-05-16" @default.
- W2059531879 modified "2023-10-01" @default.
- W2059531879 title "Multiplexed Electrochemical Protein Detection and Translation to Personalized Cancer Diagnostics" @default.
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- W2059531879 doi "https://doi.org/10.1021/ac401058v" @default.
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