FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059532635> ?p ?o ?g. }

• W2059532635 endingPage "1837" @default.
• W2059532635 startingPage "1827" @default.
• W2059532635 abstract "The activation of dopamine (DA) neurotransmission plays a crucial role in the behavioural responses to drugs of abuse. In particular, increased extracellular levels of DA within the mesolimbic pathway have been implicated in the rewarding and locomotor stimulatory properties of morphine. We investigated the behavioural responses to morphine in mice with a genetic disruption of the DA transporter (DAT), resulting in a constitutively high level of extrasynaptic DA. In the conditioned place preference test, DAT-/- mice exhibited a stronger rewarding response to morphine (5 mg/kg, s.c.) compared with control littermates. However, the same dose of morphine failed to increase locomotor activity in DAT-/- mice, whilst enhancing locomotion in DAT+/- and DAT+/+ animals. Morphine-induced analgesia was unaffected in mutant mice, but the behavioural expression of naloxone-induced withdrawal signs was blunted. In vivo voltammetry in the shell of the nucleus accumbens revealed that morphine was able to stimulate DA neurons in DAT-/- mice, resulting in the accumulation of higher extracellular DA levels compared with control animals. Morphine also induced a higher rate of c-fos transcription in the shell of the nucleus accumbens in mutant mice. We conclude that morphine-induced rewarding responses are firmly established in DAT mutant mice despite a DA transmission that is already tonically activated, and independently of any effect on locomotion. These particular behavioural responses to morphine may be associated with the action of the drug on DA release and c-fos expression in the shell of the nucleus accumbens of DAT-/- mice." @default.
• W2059532635 created "2016-06-24" @default.
• W2059532635 creator A5006041048 @default.
• W2059532635 creator A5007698609 @default.
• W2059532635 creator A5014561292 @default.
• W2059532635 creator A5022265774 @default.
• W2059532635 creator A5031825619 @default.
• W2059532635 creator A5032132304 @default.
• W2059532635 creator A5037897982 @default.
• W2059532635 creator A5038507730 @default.
• W2059532635 creator A5053971568 @default.
• W2059532635 creator A5078043271 @default.
• W2059532635 creator A5084744256 @default.
• W2059532635 date "2000-05-01" @default.
• W2059532635 modified "2023-10-12" @default.
• W2059532635 title "Increased rewarding properties of morphine in dopamine-transporter knockout mice" @default.
• W2059532635 cites W1599299698 @default.
• W2059532635 cites W1817985333 @default.
• W2059532635 cites W1828393704 @default.
• W2059532635 cites W1840520260 @default.
• W2059532635 cites W1957364299 @default.
• W2059532635 cites W1964909230 @default.
• W2059532635 cites W1973569713 @default.
• W2059532635 cites W1980041960 @default.
• W2059532635 cites W1981891173 @default.
• W2059532635 cites W1996702576 @default.
• W2059532635 cites W1996940755 @default.
• W2059532635 cites W2001865657 @default.
• W2059532635 cites W2002482831 @default.
• W2059532635 cites W2003198747 @default.
• W2059532635 cites W2007604257 @default.
• W2059532635 cites W2008963742 @default.
• W2059532635 cites W2010439035 @default.
• W2059532635 cites W2013851440 @default.
• W2059532635 cites W2014793858 @default.
• W2059532635 cites W2015995396 @default.
• W2059532635 cites W2017491485 @default.
• W2059532635 cites W2019016965 @default.
• W2059532635 cites W2028782393 @default.
• W2059532635 cites W2028852807 @default.
• W2059532635 cites W2042908150 @default.
• W2059532635 cites W2044995874 @default.
• W2059532635 cites W2046345374 @default.
• W2059532635 cites W2046983320 @default.
• W2059532635 cites W2047464854 @default.
• W2059532635 cites W2051746492 @default.
• W2059532635 cites W2054498589 @default.
• W2059532635 cites W2055207238 @default.
• W2059532635 cites W2061161259 @default.
• W2059532635 cites W2069049686 @default.
• W2059532635 cites W2079204641 @default.
• W2059532635 cites W2079310198 @default.
• W2059532635 cites W2085439006 @default.
• W2059532635 cites W2090931660 @default.
• W2059532635 cites W2092279314 @default.
• W2059532635 cites W2092902644 @default.
• W2059532635 cites W2092978910 @default.
• W2059532635 cites W2094296755 @default.
• W2059532635 cites W2112214333 @default.
• W2059532635 cites W2122592499 @default.
• W2059532635 cites W2133479791 @default.
• W2059532635 cites W2134340301 @default.
• W2059532635 cites W2149928224 @default.
• W2059532635 cites W2165398609 @default.
• W2059532635 cites W2169863475 @default.
• W2059532635 cites W2174764226 @default.
• W2059532635 cites W4322703309 @default.
• W2059532635 cites W98538444 @default.
• W2059532635 doi "https://doi.org/10.1046/j.1460-9568.2000.00063.x" @default.
• W2059532635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1904481" @default.
• W2059532635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10792459" @default.
• W2059532635 hasPublicationYear "2000" @default.
• W2059532635 type Work @default.
• W2059532635 sameAs 2059532635 @default.
• W2059532635 citedByCount "83" @default.
• W2059532635 countsByYear W20595326352012 @default.
• W2059532635 countsByYear W20595326352013 @default.
• W2059532635 countsByYear W20595326352015 @default.
• W2059532635 countsByYear W20595326352016 @default.
• W2059532635 countsByYear W20595326352017 @default.
• W2059532635 countsByYear W20595326352018 @default.
• W2059532635 countsByYear W20595326352019 @default.
• W2059532635 countsByYear W20595326352020 @default.
• W2059532635 countsByYear W20595326352021 @default.
• W2059532635 countsByYear W20595326352022 @default.
• W2059532635 countsByYear W20595326352023 @default.
• W2059532635 crossrefType "journal-article" @default.
• W2059532635 hasAuthorship W2059532635A5006041048 @default.
• W2059532635 hasAuthorship W2059532635A5007698609 @default.
• W2059532635 hasAuthorship W2059532635A5014561292 @default.
• W2059532635 hasAuthorship W2059532635A5022265774 @default.
• W2059532635 hasAuthorship W2059532635A5031825619 @default.
• W2059532635 hasAuthorship W2059532635A5032132304 @default.
• W2059532635 hasAuthorship W2059532635A5037897982 @default.
• W2059532635 hasAuthorship W2059532635A5038507730 @default.
• W2059532635 hasAuthorship W2059532635A5053971568 @default.
• W2059532635 hasAuthorship W2059532635A5078043271 @default.
• W2059532635 hasAuthorship W2059532635A5084744256 @default.

• next