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- W2059535503 abstract "1. Fasting plasma amino acid concentrations were measured in five normal subjects and six non-dialysed uraemic patients. 2. The rate of removal of amino acids from the blood of an anuric patient was measured following intravenous infusion of aminosol. 3. Plasma concentrations of aspartic acid, cystine and 3-methyl histidine were statistically significantly elevated and glutamic acid and arginine moderately elevated. Plasma concentrations of all other amino acids measured were moderately decreased or normal. 4. Intravenously infused amino acids were rapidly cleared by the tissues from the blood of an anuric patient and at 150 min following the infusion, the plasma concentrations of all amino acids, except tyrosine, were 25–60% lower than fasting levels. 5. Elevated plasma concentration of cystine in uraemic subjects was associated with administration of methionine supplements. Elevated plasma concentration of 3-methyl histidine was associated with muscle wasting. 6. From the blood amino acid clearance rates it is concluded that the regulatory processes controlling the concentration of plasma amino acids do so independently of renal function, and suggest that the effect of one amino acid on the metabolism of another is at cellular level." @default.
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- W2059535503 date "1971-05-01" @default.
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- W2059535503 title "Amino acid metabolism in uraemic patients" @default.
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- W2059535503 doi "https://doi.org/10.1016/0009-8981(71)90433-5" @default.
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