FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059550462> ?p ?o ?g. }

• W2059550462 endingPage "537" @default.
• W2059550462 startingPage "532" @default.
• W2059550462 abstract "Insulin signaling in the hypothalamus plays an important role in food intake and glucose homeostasis. Hypothalamic neuronal functions are modulated by glial cells; these form an extensive network connecting the neurons and cerebral vasculature, known as the neurovascular unit (NVU). Brain pericytes are periendothelial accessory structures of the blood-brain barrier and integral members of the NVU. However, the interaction between pericytes and neurons is largely unexplored. Here, we investigate whether brain pericytes could affect hypothalamic neuronal insulin signaling. Our immunohistochemical observations demonstrated the existence of pericytes in the mouse hypothalamus, exhibiting immunoreactivity of platelet-derived growth factor receptor β (a pericyte marker), and laminin, a basal lamina marker. We then exposed a murine hypothalamic neuronal cell line, GT1-7, to conditioned medium obtained from primary cultures of rat brain pericytes. Pericyte-conditioned medium (PCM), but not astrocyte- or aortic smooth muscle cell-conditioned medium, increased the insulin-stimulated phosphorylation of Akt in GT1-7 cells in a concentration-dependent manner. PCM also enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor β without changing its expression or localization in cytosolic or plasma membrane fractions. These results suggest that pericytes, rather than astrocytes, increase insulin sensitivity in hypothalamic neurons by releasing soluble factors under physiological conditions in the NVU." @default.
• W2059550462 created "2016-06-24" @default.
• W2059550462 creator A5000096233 @default.
• W2059550462 creator A5001116847 @default.
• W2059550462 creator A5009370621 @default.
• W2059550462 creator A5019346497 @default.
• W2059550462 creator A5026473199 @default.
• W2059550462 creator A5029410010 @default.
• W2059550462 creator A5069261773 @default.
• W2059550462 date "2015-02-01" @default.
• W2059550462 modified "2023-10-16" @default.
• W2059550462 title "Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons" @default.
• W2059550462 cites W1561443084 @default.
• W2059550462 cites W1964562779 @default.
• W2059550462 cites W1970730429 @default.
• W2059550462 cites W1986245376 @default.
• W2059550462 cites W1992883702 @default.
• W2059550462 cites W2001933610 @default.
• W2059550462 cites W2017712441 @default.
• W2059550462 cites W2018870528 @default.
• W2059550462 cites W2030541660 @default.
• W2059550462 cites W2035837038 @default.
• W2059550462 cites W2037226098 @default.
• W2059550462 cites W2045013955 @default.
• W2059550462 cites W2045228120 @default.
• W2059550462 cites W2045272143 @default.
• W2059550462 cites W2046583585 @default.
• W2059550462 cites W2066351690 @default.
• W2059550462 cites W2069911669 @default.
• W2059550462 cites W2089643815 @default.
• W2059550462 cites W2092376456 @default.
• W2059550462 cites W2104744177 @default.
• W2059550462 cites W2109290881 @default.
• W2059550462 cites W2111907475 @default.
• W2059550462 cites W2122610137 @default.
• W2059550462 cites W2129878800 @default.
• W2059550462 cites W2135456335 @default.
• W2059550462 cites W2147372806 @default.
• W2059550462 cites W2148992136 @default.
• W2059550462 cites W2156965724 @default.
• W2059550462 cites W2161839691 @default.
• W2059550462 cites W2163786444 @default.
• W2059550462 doi "https://doi.org/10.1016/j.bbrc.2015.01.016" @default.
• W2059550462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25597994" @default.
• W2059550462 hasPublicationYear "2015" @default.
• W2059550462 type Work @default.
• W2059550462 sameAs 2059550462 @default.
• W2059550462 citedByCount "13" @default.
• W2059550462 countsByYear W20595504622016 @default.
• W2059550462 countsByYear W20595504622018 @default.
• W2059550462 countsByYear W20595504622019 @default.
• W2059550462 countsByYear W20595504622020 @default.
• W2059550462 countsByYear W20595504622021 @default.
• W2059550462 countsByYear W20595504622022 @default.
• W2059550462 crossrefType "journal-article" @default.
• W2059550462 hasAuthorship W2059550462A5000096233 @default.
• W2059550462 hasAuthorship W2059550462A5001116847 @default.
• W2059550462 hasAuthorship W2059550462A5009370621 @default.
• W2059550462 hasAuthorship W2059550462A5019346497 @default.
• W2059550462 hasAuthorship W2059550462A5026473199 @default.
• W2059550462 hasAuthorship W2059550462A5029410010 @default.
• W2059550462 hasAuthorship W2059550462A5069261773 @default.
• W2059550462 hasConcept C112446052 @default.
• W2059550462 hasConcept C11960822 @default.
• W2059550462 hasConcept C123012128 @default.
• W2059550462 hasConcept C126322002 @default.
• W2059550462 hasConcept C134018914 @default.
• W2059550462 hasConcept C202751555 @default.
• W2059550462 hasConcept C2777003273 @default.
• W2059550462 hasConcept C2777391703 @default.
• W2059550462 hasConcept C2777542381 @default.
• W2059550462 hasConcept C2779306644 @default.
• W2059550462 hasConcept C2780427682 @default.
• W2059550462 hasConcept C529278444 @default.
• W2059550462 hasConcept C55493867 @default.
• W2059550462 hasConcept C71924100 @default.
• W2059550462 hasConcept C75217442 @default.
• W2059550462 hasConcept C86803240 @default.
• W2059550462 hasConcept C95444343 @default.
• W2059550462 hasConceptScore W2059550462C112446052 @default.
• W2059550462 hasConceptScore W2059550462C11960822 @default.
• W2059550462 hasConceptScore W2059550462C123012128 @default.
• W2059550462 hasConceptScore W2059550462C126322002 @default.
• W2059550462 hasConceptScore W2059550462C134018914 @default.
• W2059550462 hasConceptScore W2059550462C202751555 @default.
• W2059550462 hasConceptScore W2059550462C2777003273 @default.
• W2059550462 hasConceptScore W2059550462C2777391703 @default.
• W2059550462 hasConceptScore W2059550462C2777542381 @default.
• W2059550462 hasConceptScore W2059550462C2779306644 @default.
• W2059550462 hasConceptScore W2059550462C2780427682 @default.
• W2059550462 hasConceptScore W2059550462C529278444 @default.
• W2059550462 hasConceptScore W2059550462C55493867 @default.
• W2059550462 hasConceptScore W2059550462C71924100 @default.
• W2059550462 hasConceptScore W2059550462C75217442 @default.
• W2059550462 hasConceptScore W2059550462C86803240 @default.
• W2059550462 hasConceptScore W2059550462C95444343 @default.
• W2059550462 hasFunder F4320309807 @default.
• W2059550462 hasFunder F4320320912 @default.

• next