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• W2059551269 abstract "Phosphoinositide-specific phospholipase C (PLC) isozymes play roles in a diversity of processes including Drosophila phototransduction. In fly photoreceptor cells, the PLCβ encoded by norpA is critical for activation of TRP channels. Here, we describe a PLCβ regulator, STOPS, which encodes a SOCS box protein. Mutation of stops resulted in a reduced concentration of NORPA and a defect in stopping signaling following cessation of the light stimulus. NORPA has been proposed to have dual roles as a PLC- and GTPase-activating protein (GAP). We found that the slow termination resulting from expressing low levels of wild-type NORPA was suppressed by addition of normal amounts of an altered NORPA, which had wild-type GAP activity, but no PLC activity. STOPS is the first protein identified that specifically regulates PLCβ protein concentration. Moreover, this work demonstrates that a PLCβ derivative that does not promote TRP channel activation, still contributes to signaling in vivo." @default.
• W2059551269 created "2016-06-24" @default.
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• W2059551269 date "2008-01-01" @default.
• W2059551269 modified "2023-10-12" @default.
• W2059551269 title "The SOCS Box Protein STOPS Is Required for Phototransduction through Its Effects on Phospholipase C" @default.
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• W2059551269 doi "https://doi.org/10.1016/j.neuron.2007.11.020" @default.
• W2059551269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2253723" @default.
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