FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059552079> ?p ?o ?g. }

• W2059552079 endingPage "767" @default.
• W2059552079 startingPage "758" @default.
• W2059552079 abstract "CXCR4 is overexpressed on tumor cells from many types of human cancers. A high level of CXCR4 expression often correlates with poor prognosis, chemotherapy resistance, and metastasis. The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of receptor expression level for diagnosis or therapeutic evaluation. Two new 18F-labeled radiotracers based on an Ac-TC14012 peptide, [18F]FP-Ac-TC14012 and [18F]FB-Ac-TC14012, were synthesized and characterized. The affinities of the 2-fluoropropionate (FP)-conjugated or 4-fluorobenzoate (FB)-conjugated peptides to CXCR4-transfected Chinese hamster ovarian (CHO) cells were evaluated in a competitive binding assay with [125I]CXCL12 radioligand. The cell uptake and retention of [18F]FP-labeled and [18F]FB-labeled peptides were measured. The tumor targetability and pharmacokinetics of these two tracers were also evaluated by microPET imaging and biodistribution studies. The labeled peptides retained high binding affinity to CXCR4 and showed much higher uptake in CXCR4-positive CHO cells than in CXCR4-negative cells in vitro. The smaller and more hydrophilic [18F]FP prosthetic group resulted in higher affinity and lower nonspecific cell uptake compared to the [18F]FB-labeled peptide. Both radiotracers showed much higher accumulation in CXCR4-positive than CXCR4-negative tumor xenografts in mice and allowed clear visualization of CXCR4 expression by PET. Among the two, [18F]FP-Ac-TC14012 showed higher tumor uptake and better tumor-to-background contrast. Unlike their N-terminal 4-F-benzoate analogs, these two tracers had minimal blood retention, likely due to reduced red blood cell binding. Metabolic organs, such as the liver and kidney, also showed high uptake. When blocked with low-dose cold peptide (10 μg), the tumor uptake was significantly increased, most likely due to the increased concentration in blood circulation, as evidenced by decreased liver uptake. These results demonstrate that the [18F]FP-labeled Ac-TC14012 peptide with high tumor uptake, low nonspecific binding, and good tumor-to-background contrast promises [18F]FP-Ac-TC14012 as a PET tracer for in vivo PET imaging of CXCR4 expression." @default.
• W2059552079 created "2016-06-24" @default.
• W2059552079 creator A5013987568 @default.
• W2059552079 creator A5018249388 @default.
• W2059552079 creator A5049988163 @default.
• W2059552079 creator A5052309941 @default.
• W2059552079 creator A5056053058 @default.
• W2059552079 creator A5063849989 @default.
• W2059552079 creator A5074245029 @default.
• W2059552079 creator A5088055918 @default.
• W2059552079 creator A5089833045 @default.
• W2059552079 date "2013-05-02" @default.
• W2059552079 modified "2023-09-22" @default.
• W2059552079 title "Comparison of 18F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression" @default.
• W2059552079 cites W1759816220 @default.
• W2059552079 cites W1872945166 @default.
• W2059552079 cites W1966105418 @default.
• W2059552079 cites W1972727778 @default.
• W2059552079 cites W1975913849 @default.
• W2059552079 cites W1976028834 @default.
• W2059552079 cites W1980105125 @default.
• W2059552079 cites W1980475208 @default.
• W2059552079 cites W1980790180 @default.
• W2059552079 cites W2012415615 @default.
• W2059552079 cites W2029752274 @default.
• W2059552079 cites W2038446554 @default.
• W2059552079 cites W2040210877 @default.
• W2059552079 cites W2051517030 @default.
• W2059552079 cites W2053544594 @default.
• W2059552079 cites W2058571015 @default.
• W2059552079 cites W2059856492 @default.
• W2059552079 cites W2070590745 @default.
• W2059552079 cites W2077974469 @default.
• W2059552079 cites W2082216180 @default.
• W2059552079 cites W2083874968 @default.
• W2059552079 cites W2085876247 @default.
• W2059552079 cites W2098141802 @default.
• W2059552079 cites W2098560257 @default.
• W2059552079 cites W2104907514 @default.
• W2059552079 cites W2107877747 @default.
• W2059552079 cites W2109325347 @default.
• W2059552079 cites W2116018770 @default.
• W2059552079 cites W2127286414 @default.
• W2059552079 cites W2130448860 @default.
• W2059552079 cites W2140382736 @default.
• W2059552079 cites W2142285857 @default.
• W2059552079 cites W2145151064 @default.
• W2059552079 cites W2153804081 @default.
• W2059552079 cites W2156323704 @default.
• W2059552079 cites W2163844917 @default.
• W2059552079 cites W2167111449 @default.
• W2059552079 doi "https://doi.org/10.1007/s11307-013-0640-0" @default.
• W2059552079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3863618" @default.
• W2059552079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23636490" @default.
• W2059552079 hasPublicationYear "2013" @default.
• W2059552079 type Work @default.
• W2059552079 sameAs 2059552079 @default.
• W2059552079 citedByCount "20" @default.
• W2059552079 countsByYear W20595520792013 @default.
• W2059552079 countsByYear W20595520792014 @default.
• W2059552079 countsByYear W20595520792015 @default.
• W2059552079 countsByYear W20595520792016 @default.
• W2059552079 countsByYear W20595520792019 @default.
• W2059552079 countsByYear W20595520792020 @default.
• W2059552079 countsByYear W20595520792021 @default.
• W2059552079 countsByYear W20595520792023 @default.
• W2059552079 crossrefType "journal-article" @default.
• W2059552079 hasAuthorship W2059552079A5013987568 @default.
• W2059552079 hasAuthorship W2059552079A5018249388 @default.
• W2059552079 hasAuthorship W2059552079A5049988163 @default.
• W2059552079 hasAuthorship W2059552079A5052309941 @default.
• W2059552079 hasAuthorship W2059552079A5056053058 @default.
• W2059552079 hasAuthorship W2059552079A5063849989 @default.
• W2059552079 hasAuthorship W2059552079A5074245029 @default.
• W2059552079 hasAuthorship W2059552079A5088055918 @default.
• W2059552079 hasAuthorship W2059552079A5089833045 @default.
• W2059552079 hasBestOaLocation W20595520792 @default.
• W2059552079 hasConcept C129470790 @default.
• W2059552079 hasConcept C13373296 @default.
• W2059552079 hasConcept C150903083 @default.
• W2059552079 hasConcept C170493617 @default.
• W2059552079 hasConcept C185592680 @default.
• W2059552079 hasConcept C202751555 @default.
• W2059552079 hasConcept C207001950 @default.
• W2059552079 hasConcept C2775842073 @default.
• W2059552079 hasConcept C2777807558 @default.
• W2059552079 hasConcept C2779281246 @default.
• W2059552079 hasConcept C2780492938 @default.
• W2059552079 hasConcept C2989005 @default.
• W2059552079 hasConcept C502942594 @default.
• W2059552079 hasConcept C55493867 @default.
• W2059552079 hasConcept C67847695 @default.
• W2059552079 hasConcept C71924100 @default.
• W2059552079 hasConcept C86803240 @default.
• W2059552079 hasConceptScore W2059552079C129470790 @default.
• W2059552079 hasConceptScore W2059552079C13373296 @default.
• W2059552079 hasConceptScore W2059552079C150903083 @default.
• W2059552079 hasConceptScore W2059552079C170493617 @default.

• next