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• W2059552642 startingPage "1492" @default.
• W2059552642 abstract "Aiming to improve the potency and selectivity of scalarane sesterterpenoids, a series of natural and semisynthetic analogues, derived from the cytotoxic naturally abundant sesterterpene heteronemin (1), were evaluated for their in vitro antimicrobial and cytotoxic properties. The new sesterterpenes 16-O-methylsesterstatin 4 (6c), 17, 24-dihydroheteronemin (7a), 16, 25-deacetoxy-17, 24-dihydroheteronemin (7b), and 16-deacetoxy-25-methoxy-17, 24-dihydroheteronemin (7c) were structurally defined via physical data analyses. Scalarane sesterterpenes possessing an unsaturated 1,4-dialdehyde moiety showed potent inhibitory activity against methicillin-resistant Staphylococcus aureus at concentrations that are not significantly cytotoxic to mammalian cells. The structural features for the cytotoxicity of scalarane sesterterpenoids are discussed." @default.
• W2059552642 created "2016-06-24" @default.
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• W2059552642 date "2009-08-06" @default.
• W2059552642 modified "2023-10-10" @default.
• W2059552642 title "Scalarane Sesterterpenoids: Semisynthesis and Biological Activity" @default.
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• W2059552642 doi "https://doi.org/10.1021/np900326a" @default.
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