FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059553622> ?p ?o ?g. }

• W2059553622 endingPage "262" @default.
• W2059553622 startingPage "250" @default.
• W2059553622 abstract "Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation occurs upon promoter binding by an unknown kinase. Here, we show that the cyclin-dependent kinase 8 (CDK8) module of the Mediator complex phosphorylated regulatory sites within the TADs of STAT1, STAT3, and STAT5, including S727 within the STAT1 TAD in the interferon (IFN) signaling pathway. We also observed a CDK8 requirement for IFN-γ-inducible antiviral responses. Microarray analyses revealed that CDK8-mediated STAT1 phosphorylation positively or negatively regulated over 40% of IFN-γ-responsive genes, and RNA polymerase II occupancy correlated with gene expression changes. This divergent regulation occurred despite similar CDK8 occupancy at both S727 phosphorylation-dependent and -independent genes. These data identify CDK8 as a key regulator of STAT1 and antiviral responses and suggest a general role for CDK8 in STAT-mediated transcription. As such, CDK8 represents a promising target for therapeutic manipulation of cytokine responses." @default.
• W2059553622 created "2016-06-24" @default.
• W2059553622 creator A5001406111 @default.
• W2059553622 creator A5010842007 @default.
• W2059553622 creator A5016041137 @default.
• W2059553622 creator A5023201529 @default.
• W2059553622 creator A5049151627 @default.
• W2059553622 creator A5052930466 @default.
• W2059553622 creator A5055868947 @default.
• W2059553622 creator A5069299747 @default.
• W2059553622 creator A5069303108 @default.
• W2059553622 creator A5071343622 @default.
• W2059553622 creator A5077764816 @default.
• W2059553622 date "2013-02-01" @default.
• W2059553622 modified "2023-10-15" @default.
• W2059553622 title "CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response" @default.
• W2059553622 cites W1510347472 @default.
• W2059553622 cites W1580786676 @default.
• W2059553622 cites W1656358829 @default.
• W2059553622 cites W1821858011 @default.
• W2059553622 cites W1968234285 @default.
• W2059553622 cites W1984901090 @default.
• W2059553622 cites W1986642666 @default.
• W2059553622 cites W1989883893 @default.
• W2059553622 cites W1993034428 @default.
• W2059553622 cites W2008027677 @default.
• W2059553622 cites W2011466676 @default.
• W2059553622 cites W2011542817 @default.
• W2059553622 cites W2014596538 @default.
• W2059553622 cites W2016240370 @default.
• W2059553622 cites W2024093804 @default.
• W2059553622 cites W2030411429 @default.
• W2059553622 cites W2030865745 @default.
• W2059553622 cites W2034469841 @default.
• W2059553622 cites W2044335855 @default.
• W2059553622 cites W2045575961 @default.
• W2059553622 cites W2052547687 @default.
• W2059553622 cites W2058565051 @default.
• W2059553622 cites W2058755167 @default.
• W2059553622 cites W2060323540 @default.
• W2059553622 cites W2061565653 @default.
• W2059553622 cites W2062792770 @default.
• W2059553622 cites W2066214252 @default.
• W2059553622 cites W2066618750 @default.
• W2059553622 cites W2077217951 @default.
• W2059553622 cites W2079357798 @default.
• W2059553622 cites W2081567150 @default.
• W2059553622 cites W2086677653 @default.
• W2059553622 cites W2087814657 @default.
• W2059553622 cites W2091785290 @default.
• W2059553622 cites W2092289677 @default.
• W2059553622 cites W2092361302 @default.
• W2059553622 cites W2093467153 @default.
• W2059553622 cites W2098158482 @default.
• W2059553622 cites W2105594404 @default.
• W2059553622 cites W2107295567 @default.
• W2059553622 cites W2118121369 @default.
• W2059553622 cites W2138294548 @default.
• W2059553622 cites W2150317970 @default.
• W2059553622 cites W2153050742 @default.
• W2059553622 cites W2158434164 @default.
• W2059553622 cites W2169413646 @default.
• W2059553622 cites W2170005506 @default.
• W2059553622 cites W2175853567 @default.
• W2059553622 cites W2275533696 @default.
• W2059553622 cites W4298710699 @default.
• W2059553622 doi "https://doi.org/10.1016/j.immuni.2012.10.017" @default.
• W2059553622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3580287" @default.
• W2059553622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23352233" @default.
• W2059553622 hasPublicationYear "2013" @default.
• W2059553622 type Work @default.
• W2059553622 sameAs 2059553622 @default.
• W2059553622 citedByCount "208" @default.
• W2059553622 countsByYear W20595536222013 @default.
• W2059553622 countsByYear W20595536222014 @default.
• W2059553622 countsByYear W20595536222015 @default.
• W2059553622 countsByYear W20595536222016 @default.
• W2059553622 countsByYear W20595536222017 @default.
• W2059553622 countsByYear W20595536222018 @default.
• W2059553622 countsByYear W20595536222019 @default.
• W2059553622 countsByYear W20595536222020 @default.
• W2059553622 countsByYear W20595536222021 @default.
• W2059553622 countsByYear W20595536222022 @default.
• W2059553622 countsByYear W20595536222023 @default.
• W2059553622 crossrefType "journal-article" @default.
• W2059553622 hasAuthorship W2059553622A5001406111 @default.
• W2059553622 hasAuthorship W2059553622A5010842007 @default.
• W2059553622 hasAuthorship W2059553622A5016041137 @default.
• W2059553622 hasAuthorship W2059553622A5023201529 @default.
• W2059553622 hasAuthorship W2059553622A5049151627 @default.
• W2059553622 hasAuthorship W2059553622A5052930466 @default.
• W2059553622 hasAuthorship W2059553622A5055868947 @default.
• W2059553622 hasAuthorship W2059553622A5069299747 @default.
• W2059553622 hasAuthorship W2059553622A5069303108 @default.
• W2059553622 hasAuthorship W2059553622A5071343622 @default.
• W2059553622 hasAuthorship W2059553622A5077764816 @default.
• W2059553622 hasBestOaLocation W20595536221 @default.
• W2059553622 hasConcept C101762097 @default.

• next