Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059557070> ?p ?o ?g. }
- W2059557070 endingPage "60" @default.
- W2059557070 startingPage "51" @default.
- W2059557070 abstract "IFNγ is strongly related to mast cell-associated diseases. There are many reports that IFNγ inhibits mast cell degranulation. However, inflammatory cytokine production in mast cells stimulated with IFNγ has not yet been clearly investigated. Therefore, we aimed to investigate the signaling pathways of cytokine production in mast cells stimulated with IFNγ. Human mast cell line (HMC)-1 or mouse bone marrow-derived mast cells (BMMCs) were stimulated with IFNγ (100 units) for time periods indicated. Expressions of proteins and mRNAs of cytokines were determined by ELISA and RT-PCR, respectively, activities of MAP kinases, PKC, JAK1/2, and STAT1 on tyrosine 701 and serine 727 by immunoblotting, the DNA-binding activity of the transcription factors by electrophoretic mobility shift assay. IFNγ-stimulated mast cells showed increase in expressions of proteins and mRNAs of inflammatory cytokines, phosphorylations of MAP kinases, PKCα and βI, JAK1/2, and STAT1 on tyrosine 701 and serine 727. JAK inhibitor or PKC inhibitors inhibited the phosphorylations of p38 kinase, STAT1 on serine 727, and activities of NF-κB and AP-1 compared to IFNγ stimulation alone. These data suggest that IFNγ-stimulated mast cells induce productions of inflammatory cytokines through PKC/p38/NF-κB and AP-1 pathways, not through classical JAK/STAT1 pathway, in both mast cells." @default.
- W2059557070 created "2016-06-24" @default.
- W2059557070 creator A5021524792 @default.
- W2059557070 creator A5030363363 @default.
- W2059557070 creator A5041924531 @default.
- W2059557070 creator A5078381923 @default.
- W2059557070 date "2009-04-01" @default.
- W2059557070 modified "2023-09-25" @default.
- W2059557070 title "Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNγ" @default.
- W2059557070 cites W1505199498 @default.
- W2059557070 cites W1514982946 @default.
- W2059557070 cites W1531539296 @default.
- W2059557070 cites W1593839485 @default.
- W2059557070 cites W1734669034 @default.
- W2059557070 cites W1752860901 @default.
- W2059557070 cites W1900326547 @default.
- W2059557070 cites W1909525521 @default.
- W2059557070 cites W1971819575 @default.
- W2059557070 cites W1974185057 @default.
- W2059557070 cites W1975602003 @default.
- W2059557070 cites W1975996690 @default.
- W2059557070 cites W1992535927 @default.
- W2059557070 cites W1995830191 @default.
- W2059557070 cites W1996932153 @default.
- W2059557070 cites W1999767268 @default.
- W2059557070 cites W2014075948 @default.
- W2059557070 cites W2014623953 @default.
- W2059557070 cites W2015082452 @default.
- W2059557070 cites W2035046631 @default.
- W2059557070 cites W2035423094 @default.
- W2059557070 cites W2037673410 @default.
- W2059557070 cites W2037735814 @default.
- W2059557070 cites W2040270721 @default.
- W2059557070 cites W2044335855 @default.
- W2059557070 cites W2048168963 @default.
- W2059557070 cites W2077246212 @default.
- W2059557070 cites W2078844752 @default.
- W2059557070 cites W2079087011 @default.
- W2059557070 cites W2087260797 @default.
- W2059557070 cites W2091471938 @default.
- W2059557070 cites W2092289677 @default.
- W2059557070 cites W2092628518 @default.
- W2059557070 cites W2093184750 @default.
- W2059557070 cites W2100743972 @default.
- W2059557070 cites W2103565638 @default.
- W2059557070 cites W2128513949 @default.
- W2059557070 cites W2130068482 @default.
- W2059557070 cites W2131322950 @default.
- W2059557070 cites W2135528327 @default.
- W2059557070 cites W2142240308 @default.
- W2059557070 cites W2145157825 @default.
- W2059557070 cites W2157962982 @default.
- W2059557070 cites W2158356076 @default.
- W2059557070 cites W2162201817 @default.
- W2059557070 cites W2167017590 @default.
- W2059557070 cites W2169716034 @default.
- W2059557070 cites W3145024633 @default.
- W2059557070 cites W4229688459 @default.
- W2059557070 doi "https://doi.org/10.1016/j.cyto.2008.12.008" @default.
- W2059557070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19231233" @default.
- W2059557070 hasPublicationYear "2009" @default.
- W2059557070 type Work @default.
- W2059557070 sameAs 2059557070 @default.
- W2059557070 citedByCount "17" @default.
- W2059557070 countsByYear W20595570702012 @default.
- W2059557070 countsByYear W20595570702013 @default.
- W2059557070 countsByYear W20595570702014 @default.
- W2059557070 countsByYear W20595570702015 @default.
- W2059557070 countsByYear W20595570702017 @default.
- W2059557070 countsByYear W20595570702019 @default.
- W2059557070 countsByYear W20595570702020 @default.
- W2059557070 countsByYear W20595570702023 @default.
- W2059557070 crossrefType "journal-article" @default.
- W2059557070 hasAuthorship W2059557070A5021524792 @default.
- W2059557070 hasAuthorship W2059557070A5030363363 @default.
- W2059557070 hasAuthorship W2059557070A5041924531 @default.
- W2059557070 hasAuthorship W2059557070A5078381923 @default.
- W2059557070 hasConcept C122862929 @default.
- W2059557070 hasConcept C153911025 @default.
- W2059557070 hasConcept C170493617 @default.
- W2059557070 hasConcept C185592680 @default.
- W2059557070 hasConcept C195794163 @default.
- W2059557070 hasConcept C203014093 @default.
- W2059557070 hasConcept C2777003663 @default.
- W2059557070 hasConcept C2778690821 @default.
- W2059557070 hasConcept C2779726688 @default.
- W2059557070 hasConcept C42362537 @default.
- W2059557070 hasConcept C49802076 @default.
- W2059557070 hasConcept C502942594 @default.
- W2059557070 hasConcept C51551487 @default.
- W2059557070 hasConcept C55493867 @default.
- W2059557070 hasConcept C57074206 @default.
- W2059557070 hasConcept C62478195 @default.
- W2059557070 hasConcept C74172505 @default.
- W2059557070 hasConcept C86803240 @default.
- W2059557070 hasConcept C95444343 @default.
- W2059557070 hasConceptScore W2059557070C122862929 @default.
- W2059557070 hasConceptScore W2059557070C153911025 @default.