Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059557559> ?p ?o ?g. }
- W2059557559 endingPage "523" @default.
- W2059557559 startingPage "518" @default.
- W2059557559 abstract "Summary Objective To analyse aspects of mineral metabolism, bone mineral density (BMD), bone remodelling activity and serum IGF‐1 levels in children with chronic cholestatic disease (CCLD). Patients and measurements A total of 13 children with chronic cholestatic liver disease (CCLD; mean age 7·2 ± 4·8 years) and 22 control subjects (mean age 7·6 ± 4·5 years) were studied. Serum osteocalcin, bone alkaline phosphatase (BAP), 25‐hydroxyvitamin D, PTH and IGF‐1 levels and urinary deoxypyridinoline were determined. BMD was measured by dual‐energy X‐ray absorptiometry in the lumbar spine, total hip and whole body. Lumbar spine areal BMD was converted mathematically to apparent volumetric BMD (aBMD) and corrected for the bone age of the patient. Results Z‐score of lumbar spine BMD was lower in CCLD patients than in controls and the difference was maintained when BMD was expressed as aBMD (control = 0·107 ± 0·02 vs. CCLD = 0·092 ± 0·02 g/cm 3 , P < 0·05) and after conversion for bone age. All participants showed normal 25‐hydroxyvitamin D levels, with no significant differences in serum levels of 25‐hydroxyvitamin D and PTH between groups. IGF‐1 levels were significantly lower in the CCLD group (control = 19·6 ± 16·8 vs. CCLD = 6·4 ± 7·6 nmol/l, P < 0·05) and a positive correlation was observed between whole body BMD and IGF‐1 in this group. Conclusions These results indicate that CCLD limits bone mass gain in children. A reduction in hepatic IGF‐1 production might be responsible, at least in part, for the low bone mass of these patients." @default.
- W2059557559 created "2016-06-24" @default.
- W2059557559 creator A5006137288 @default.
- W2059557559 creator A5027214121 @default.
- W2059557559 creator A5063762276 @default.
- W2059557559 creator A5071660342 @default.
- W2059557559 creator A5074311724 @default.
- W2059557559 creator A5084748364 @default.
- W2059557559 date "2007-02-08" @default.
- W2059557559 modified "2023-10-17" @default.
- W2059557559 title "Impairment of bone mass development in children with chronic cholestatic liver disease" @default.
- W2059557559 cites W1615229175 @default.
- W2059557559 cites W1964567423 @default.
- W2059557559 cites W1965355198 @default.
- W2059557559 cites W1967223598 @default.
- W2059557559 cites W1982498195 @default.
- W2059557559 cites W1991551792 @default.
- W2059557559 cites W1992267135 @default.
- W2059557559 cites W2010663321 @default.
- W2059557559 cites W2017165492 @default.
- W2059557559 cites W2018516675 @default.
- W2059557559 cites W2027239420 @default.
- W2059557559 cites W2029645035 @default.
- W2059557559 cites W2038709117 @default.
- W2059557559 cites W2057769405 @default.
- W2059557559 cites W2058825202 @default.
- W2059557559 cites W2068503643 @default.
- W2059557559 cites W2071300057 @default.
- W2059557559 cites W2080155376 @default.
- W2059557559 cites W2093219720 @default.
- W2059557559 cites W2093598156 @default.
- W2059557559 cites W2095607759 @default.
- W2059557559 cites W2119783774 @default.
- W2059557559 cites W2164496980 @default.
- W2059557559 cites W2319902945 @default.
- W2059557559 cites W3190705041 @default.
- W2059557559 cites W4236362294 @default.
- W2059557559 cites W4248251331 @default.
- W2059557559 cites W4251369894 @default.
- W2059557559 cites W4254382800 @default.
- W2059557559 cites W4255221283 @default.
- W2059557559 doi "https://doi.org/10.1111/j.1365-2265.2007.02765.x" @default.
- W2059557559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17371469" @default.
- W2059557559 hasPublicationYear "2007" @default.
- W2059557559 type Work @default.
- W2059557559 sameAs 2059557559 @default.
- W2059557559 citedByCount "9" @default.
- W2059557559 countsByYear W20595575592012 @default.
- W2059557559 countsByYear W20595575592016 @default.
- W2059557559 countsByYear W20595575592017 @default.
- W2059557559 countsByYear W20595575592023 @default.
- W2059557559 crossrefType "journal-article" @default.
- W2059557559 hasAuthorship W2059557559A5006137288 @default.
- W2059557559 hasAuthorship W2059557559A5027214121 @default.
- W2059557559 hasAuthorship W2059557559A5063762276 @default.
- W2059557559 hasAuthorship W2059557559A5071660342 @default.
- W2059557559 hasAuthorship W2059557559A5074311724 @default.
- W2059557559 hasAuthorship W2059557559A5084748364 @default.
- W2059557559 hasConcept C126322002 @default.
- W2059557559 hasConcept C131075544 @default.
- W2059557559 hasConcept C134018914 @default.
- W2059557559 hasConcept C160160445 @default.
- W2059557559 hasConcept C170033053 @default.
- W2059557559 hasConcept C181199279 @default.
- W2059557559 hasConcept C185592680 @default.
- W2059557559 hasConcept C2776169692 @default.
- W2059557559 hasConcept C2776541429 @default.
- W2059557559 hasConcept C2776886416 @default.
- W2059557559 hasConcept C2780787237 @default.
- W2059557559 hasConcept C55493867 @default.
- W2059557559 hasConcept C71924100 @default.
- W2059557559 hasConceptScore W2059557559C126322002 @default.
- W2059557559 hasConceptScore W2059557559C131075544 @default.
- W2059557559 hasConceptScore W2059557559C134018914 @default.
- W2059557559 hasConceptScore W2059557559C160160445 @default.
- W2059557559 hasConceptScore W2059557559C170033053 @default.
- W2059557559 hasConceptScore W2059557559C181199279 @default.
- W2059557559 hasConceptScore W2059557559C185592680 @default.
- W2059557559 hasConceptScore W2059557559C2776169692 @default.
- W2059557559 hasConceptScore W2059557559C2776541429 @default.
- W2059557559 hasConceptScore W2059557559C2776886416 @default.
- W2059557559 hasConceptScore W2059557559C2780787237 @default.
- W2059557559 hasConceptScore W2059557559C55493867 @default.
- W2059557559 hasConceptScore W2059557559C71924100 @default.
- W2059557559 hasIssue "4" @default.
- W2059557559 hasLocation W20595575591 @default.
- W2059557559 hasLocation W20595575592 @default.
- W2059557559 hasOpenAccess W2059557559 @default.
- W2059557559 hasPrimaryLocation W20595575591 @default.
- W2059557559 hasRelatedWork W2000565237 @default.
- W2059557559 hasRelatedWork W2025377133 @default.
- W2059557559 hasRelatedWork W2059992169 @default.
- W2059557559 hasRelatedWork W2085672309 @default.
- W2059557559 hasRelatedWork W2123064724 @default.
- W2059557559 hasRelatedWork W2321391090 @default.
- W2059557559 hasRelatedWork W2370365187 @default.
- W2059557559 hasRelatedWork W2417140981 @default.
- W2059557559 hasRelatedWork W3083499455 @default.