FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059562287> ?p ?o ?g. }

• W2059562287 endingPage "900" @default.
• W2059562287 startingPage "894" @default.
• W2059562287 abstract "Summary Objectives IGF‐1 and its binding proteins are involved in the pathogenesis of atherosclerosis. We designed this study to unravel the relationship of the IGF system with peripheral arterial disease (PAD). Design Case‐control, cross‐sectional study. Measurements Serum levels of IGF‐1, IGFBP‐3 and acid labile subunit (ALS) were measured in 96 PAD patients and 89 controls. In 28 patients who underwent peripheral angiography, C‐reactive protein (CRP), IGF‐1, IGFBP‐3 and ALS were measured in blood from femoral vein of the affected limb and aorta. Results Compared to controls, PAD patients showed lower levels of IGFBP‐3 (3569 ± 115 vs. 3106 ± 107 µg/l, P < 0·01), and ALS (12·2 ± 0·5 vs. 8·3 ± 0·5 mg/l, P < 0·01). In PAD, concentrations of IGFBP‐3 and ALS were significantly lower in patients with ankle/brachial index less than median than in those with a less severe PAD. In the affected limb, CRP venous‐arterial difference correlated negatively with that of IGF‐1 (ρ = −0·57, P < 0·01), and positively with that of IGFBP‐3 (ρ = 0·63, P < 0·01). At multivariate analysis, a high transfemoral gradient of CRP was independently associated with a low transfemoral gradient of IGF‐1 (β coefficient = −0·48, P < 0·01), and a high transfemoral gradient of IGFBP‐3 (β coefficient = 0·22, P < 0·05). Conclusions This study is the first to demonstrate that the systemic levels of IGF axis components are associated with the presence and severity of PAD, and that the inflammatory status of the ischaemic limb affects the transfemoral concentrations of IGF‐1 and IGFBP‐3. Due to the importance of IGF axis in modulating atherosclerotic plaque progression, our data may contribute to a better understanding of PAD pathophysiology." @default.
• W2059562287 created "2016-06-24" @default.
• W2059562287 creator A5007195190 @default.
• W2059562287 creator A5051324603 @default.
• W2059562287 creator A5063936702 @default.
• W2059562287 creator A5065521559 @default.
• W2059562287 creator A5070034601 @default.
• W2059562287 creator A5077499862 @default.
• W2059562287 creator A5087293057 @default.
• W2059562287 creator A5090989122 @default.
• W2059562287 date "2008-11-12" @default.
• W2059562287 modified "2023-10-17" @default.
• W2059562287 title "IGF system and peripheral arterial disease: relationship with disease severity and inflammatory status of the affected limb" @default.
• W2059562287 cites W1616845142 @default.
• W2059562287 cites W1896749326 @default.
• W2059562287 cites W1963989896 @default.
• W2059562287 cites W1964527977 @default.
• W2059562287 cites W1974004139 @default.
• W2059562287 cites W1985360214 @default.
• W2059562287 cites W1985418645 @default.
• W2059562287 cites W1988251378 @default.
• W2059562287 cites W1995012519 @default.
• W2059562287 cites W1997329894 @default.
• W2059562287 cites W2017154680 @default.
• W2059562287 cites W2024537012 @default.
• W2059562287 cites W2025437836 @default.
• W2059562287 cites W2033420871 @default.
• W2059562287 cites W2036867263 @default.
• W2059562287 cites W2053634523 @default.
• W2059562287 cites W2055330386 @default.
• W2059562287 cites W2059627527 @default.
• W2059562287 cites W2077548365 @default.
• W2059562287 cites W2078224119 @default.
• W2059562287 cites W2078656440 @default.
• W2059562287 cites W2079773807 @default.
• W2059562287 cites W2086969805 @default.
• W2059562287 cites W2091097539 @default.
• W2059562287 cites W2103063855 @default.
• W2059562287 cites W2104104049 @default.
• W2059562287 cites W2115525455 @default.
• W2059562287 cites W2118678876 @default.
• W2059562287 cites W2119087060 @default.
• W2059562287 cites W2122358213 @default.
• W2059562287 cites W2133870378 @default.
• W2059562287 cites W2135125642 @default.
• W2059562287 cites W2136823073 @default.
• W2059562287 cites W2145397058 @default.
• W2059562287 cites W2148239418 @default.
• W2059562287 cites W2148878791 @default.
• W2059562287 cites W2153860672 @default.
• W2059562287 cites W2155645904 @default.
• W2059562287 cites W2159087408 @default.
• W2059562287 cites W2168911590 @default.
• W2059562287 cites W2207498178 @default.
• W2059562287 cites W2395890894 @default.
• W2059562287 doi "https://doi.org/10.1111/j.1365-2265.2008.03269.x" @default.
• W2059562287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18410545" @default.
• W2059562287 hasPublicationYear "2008" @default.
• W2059562287 type Work @default.
• W2059562287 sameAs 2059562287 @default.
• W2059562287 citedByCount "9" @default.
• W2059562287 countsByYear W20595622872016 @default.
• W2059562287 countsByYear W20595622872018 @default.
• W2059562287 countsByYear W20595622872019 @default.
• W2059562287 countsByYear W20595622872022 @default.
• W2059562287 countsByYear W20595622872023 @default.
• W2059562287 crossrefType "journal-article" @default.
• W2059562287 hasAuthorship W2059562287A5007195190 @default.
• W2059562287 hasAuthorship W2059562287A5051324603 @default.
• W2059562287 hasAuthorship W2059562287A5063936702 @default.
• W2059562287 hasAuthorship W2059562287A5065521559 @default.
• W2059562287 hasAuthorship W2059562287A5070034601 @default.
• W2059562287 hasAuthorship W2059562287A5077499862 @default.
• W2059562287 hasAuthorship W2059562287A5087293057 @default.
• W2059562287 hasAuthorship W2059562287A5090989122 @default.
• W2059562287 hasConcept C126322002 @default.
• W2059562287 hasConcept C134018914 @default.
• W2059562287 hasConcept C141071460 @default.
• W2059562287 hasConcept C164705383 @default.
• W2059562287 hasConcept C2777466421 @default.
• W2059562287 hasConcept C2778640784 @default.
• W2059562287 hasConcept C2779980429 @default.
• W2059562287 hasConcept C2780942790 @default.
• W2059562287 hasConcept C3018348675 @default.
• W2059562287 hasConcept C46762472 @default.
• W2059562287 hasConcept C71924100 @default.
• W2059562287 hasConcept C90924648 @default.
• W2059562287 hasConceptScore W2059562287C126322002 @default.
• W2059562287 hasConceptScore W2059562287C134018914 @default.
• W2059562287 hasConceptScore W2059562287C141071460 @default.
• W2059562287 hasConceptScore W2059562287C164705383 @default.
• W2059562287 hasConceptScore W2059562287C2777466421 @default.
• W2059562287 hasConceptScore W2059562287C2778640784 @default.
• W2059562287 hasConceptScore W2059562287C2779980429 @default.
• W2059562287 hasConceptScore W2059562287C2780942790 @default.
• W2059562287 hasConceptScore W2059562287C3018348675 @default.
• W2059562287 hasConceptScore W2059562287C46762472 @default.
• W2059562287 hasConceptScore W2059562287C71924100 @default.

• next